DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment htl and Fgfr3

DIOPT Version :9

Sequence 1:	NP_524394.2	Gene:	htl / 42160	FlyBaseID:	FBgn0010389	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	XP_006251452.1	Gene:	Fgfr3 / 84489	RGDID:	620714	Length:	804	Species:	Rattus norvegicus

Alignment Length:	691	Identity:	278/691 - (40%)
Similarity:	387/691 - (56%)	Gaps:	82/691 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 SSADLDDGAADDDDNKADLPVNVSSKPYWRNPKKM-SFLQTRPSGSLLTLNCHALGNPEPNITWY 138
            ||.|.:||....:|..|         |||..|::| ..|...|:.:.:...|.|.|||.|:|:|.
  Rat   128 SSGDDEDGEDVAEDTGA---------PYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWL 183

  Fly   139 RNGTV---DWTRGYGSLKRNRWTLTMEDLVPGDCGNYTCKVCNSLGCIRHDTQVIVSDRVNHKPI 200
            :||..   :...|...|:..:|:|.||.:||.|.|||||.|.|..|.||....:.|.:|..|:||
  Rat   184 KNGKEFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPI 248

  Fly   201 LMTG-PLNLTLVVNSTGSMHCKYLSDLTSKKAWIFVPCHGMTNCSN-----------NRSIIAED 253
            |..| |.|.|.|:.|....|||..||......|:   .|...|.|.           .:|.|:|:
  Rat   249 LQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWL---KHVEVNGSKVGPDGTPYVTVLKSWISEN 310

  Fly   254 KD---QLDFVNVRMEQEGWYTCVESNSLGQSNSTAYLRV-------VRSLHVLEAGVASGSLHST 308
            .:   :|...||.....|.|.|..:|.:|.:....:|||       ...:.|.|||        :
  Rat   311 VEADARLRLANVSERDGGEYLCRATNFIGVAEKAFWLRVHGPQAAEEELMEVDEAG--------S 367

  Fly   309 SFVYIFVFGGLIFIFMTTLFVFYAIRKMKHEKVLKQRI--ETVHQWTKKVIIFKPEGGGDSSGSM 371
            .:..:..:|...|:|   :.|..|:...:.....|:.:  .|||:.::..:..:.....:|:.||
  Rat   368 VYAGVLSYGVGFFLF---ILVVAAVTLCRLRSPPKKGLGSPTVHKVSRFPLKRQVTVSLESNSSM 429

  Fly   372 DTMIMPVVRIQKQRTTVLQNGNEP--APFNEYEFPLDSNWELPRSHLVLGATLGEGAFGRVVMAE 434
            ::. .|:|||.:     |.:|..|  |..:|.|.|.|..|||.|:.|.||..||||.||:|||||
  Rat   430 NSN-TPLVRIAR-----LSSGEGPVLANVSELELPADPKWELSRTRLTLGKPLGEGCFGQVVMAE 488

  Fly   435 ---------VNNAIVAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQNGPLYVIV 490
                     .....|||||:|:..||.|::.||.|||:||:||:|.|||||||.|:|.|||||:|
  Rat   489 AIGIDKDRTAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLV 553

  Fly   491 EYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHR 555
            |||..|||::||...||.|.|...|:.:.|...    :|.|||:..|:|:||||:||||::||||
  Rat   554 EYAAKGNLREFLRARRPPGMDYSFDACRLPEEQ----LTCKDLVSCAYQVARGMEYLASQKCIHR 614

  Fly   556 DLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYG 620
            |||||||||::|.|:||||||||||:.:.|||:|.||||||:||||||:|.::.|..:|||||:|
  Rat   615 DLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFG 679

  Fly   621 ILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIV 685
            :|||||.|.|..|||.| ..|||:..|..|.||:|||.|:.::|::||:|||.....||.|.::|
  Rat   680 VLLWEIFTLGGSPYPGI-PVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAVPSQRPTFKQLV 743

  Fly   686 EYMDKLL--QTKEDYLDVDI-------ANLDTPPSTSDEEE 717
            |.:|::|  .:.::|||:.:       ...|||.|:|..::
  Rat   744 EDLDRILTVTSTDEYLDLSVPFEQYSPGGQDTPSSSSSGDD 784

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	112..191	CDD:299845	31/81 (38%)
		IG_like	113..191	CDD:214653	30/80 (38%)
		IG_like	205..289	CDD:214653	26/97 (27%)
		PKc_like	404..692	CDD:304357	165/296 (56%)
		STYKc	416..688	CDD:214568	158/280 (56%)
Fgfr3	XP_006251452.1	IGc2	51..108	CDD:197706
		IG	52..123	CDD:214652
		Ig2_FGFR	155..239	CDD:143265	31/83 (37%)
		IG_like	254..349	CDD:214653	26/97 (27%)
		Ig3_FGFR	262..350	CDD:143175	23/90 (26%)
		PTKc_FGFR3	457..790	CDD:173652	174/333 (52%)
		Pkinase_Tyr	470..746	CDD:285015	158/280 (56%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	326	1.000	Domainoid score	I1150
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55437
Inparanoid	1	1.050	465	1.000	Inparanoid score	I1477
OMA	1	1.010	-	-		QHG50158
OrthoDB	1	1.010	-	-		D119660at33208
OrthoFinder	1	1.000	-	-		FOG0000923
OrthoInspector	1	1.000	-	-		mtm9075
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X537
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.780