DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment htl and AT1G74360

DIOPT Version :9

Sequence 1:	NP_524394.2	Gene:	htl / 42160	FlyBaseID:	FBgn0010389	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_565084.1	Gene:	AT1G74360 / 843777	AraportID:	AT1G74360	Length:	1106	Species:	Arabidopsis thaliana

Alignment Length:	548	Identity:	119/548 - (21%)
Similarity:	203/548 - (37%)	Gaps:	143/548 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   206 LNLTL------VVNSTGSMHCKYLSDLTSKKAWIFVPCHGMTNCSNNRSIIAEDKDQLD------ 258
            ||||.      :....|::.|....||:            ..|.|.|......|.::|.
plant   622 LNLTRNNFSGEIPQEIGNLKCLQNLDLS------------FNNFSGNFPTSLNDLNELSKFNISY 674

  Fly   259 --FVNVRMEQEGWYTCVESNS-LG------------QSNSTAYL--RVV----RSLHVLEAGVAS 302
              |::..:...|.....:.:| ||            ..|:|..:  :|:    |:|.::...:|.
plant   675 NPFISGAIPTTGQVATFDKDSFLGNPLLRFPSFFNQSGNNTRKISNQVLGNRPRTLLLIWISLAL 739

  Fly   303 GSLHSTSFVYIFVFGGLIFIFMTTLFVFYAIRKMKHEKVLKQRIETVHQWTKKVIIFKPEGGGDS 367
                :.:|:...|..|::      |.|..|.|:.:.:  |....:|.|..|.       ..||.|
plant   740 ----ALAFIACLVVSGIV------LMVVKASREAEID--LLDGSKTRHDMTS-------SSGGSS 785

  Fly   368 ---SGSMDTMIMPVVRIQKQRTTVLQNGNEPAPFNEYEFPLDSNWELPRSHLVLGATLGEGAFGR 429
               ||.     :.|:|:.|...|........:.|:|..                  .:|.|.:|.
plant   786 PWLSGK-----IKVIRLDKSTFTYADILKATSNFSEER------------------VVGRGGYGT 827

  Fly   430 VVMAEV-NNAIVAVKMVKEGHTDDDIASLVREMEVMKIIG----RHINIINLLGCCSQNGPLYVI 489
            |....: :...||||.::...|:.: .....||||:....    .|.|::.|.|.|.......::
plant   828 VYRGVLPDGREVAVKKLQREGTEAE-KEFRAEMEVLSANAFGDWAHPNLVRLYGWCLDGSEKILV 891

  Fly   490 VEYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMDYLASRRC-- 552
            .||...|:|::.:         .|:...|           .|..|..|..:|||:.:| ...|
plant   892 HEYMGGGSLEELI---------TDKTKLQ-----------WKKRIDIATDVARGLVFL-HHECYP 935

  Fly   553 --IHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSD 615
              :|||:.|.|||:......::.||||||.:...|.: .:|.....|.::|||..|.....::.|
plant   936 SIVHRDVKASNVLLDKHGNARVTDFGLARLLNVGDSH-VSTVIAGTIGYVAPEYGQTWQATTRGD 999

  Fly   616 VWSYGILLWEIMTYGQQPYPTIMSAEELYT----YLMSGQRM----------EKPAKCSMNIYIL 666
            |:|||:|..|:.| |::   .:...||...    .:|:|...          .||...:..:..|
plant  1000 VYSYGVLTMELAT-GRR---AVDGGEECLVEWARRVMTGNMTAKGSPITLSGTKPGNGAEQMTEL 1060

  Fly   667 MR---QCWHFNADDRPPFTEIVEYMDKL 691
            ::   :|...:...||...|::..:.|:
plant  1061 LKIGVKCTADHPQARPNMKEVLAMLVKI 1088

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	112..191	CDD:299845
		IG_like	113..191	CDD:214653
		IG_like	205..289	CDD:214653	20/111 (18%)
		PKc_like	404..692	CDD:304357	73/314 (23%)
		STYKc	416..688	CDD:214568	72/297 (24%)
AT1G74360	NP_565084.1	PLN00113	43..1085	CDD:215061	118/543 (22%)
		LRR_RI	<106..342	CDD:238064
		leucine-rich repeat	113..136	CDD:275380
		leucine-rich repeat	137..158	CDD:275380
		leucine-rich repeat	159..183	CDD:275380
		leucine-rich repeat	184..207	CDD:275380
		leucine-rich repeat	208..253	CDD:275380
		leucine-rich repeat	254..277	CDD:275380
		LRR_RI	276..481	CDD:238064
		leucine-rich repeat	278..301	CDD:275380
		leucine-rich repeat	302..325	CDD:275380
		leucine-rich repeat	326..374	CDD:275380
		leucine-rich repeat	375..398	CDD:275380
		leucine-rich repeat	399..422	CDD:275380
		leucine-rich repeat	423..446	CDD:275380
		leucine-rich repeat	447..468	CDD:275380
		leucine-rich repeat	546..595	CDD:275380
		leucine-rich repeat	596..617	CDD:275380
		leucine-rich repeat	619..642	CDD:275380	5/19 (26%)
		leucine-rich repeat	643..666	CDD:275380	6/34 (18%)
		STKc_IRAK	820..1088	CDD:270968	72/294 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910