DRSC/TRiP Functional Genomics Resources

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Protein Alignment htl and Src

DIOPT Version :10

Sequence 1:NP_524394.2 Gene:htl / 42160 FlyBaseID:FBgn0010389 Length:729 Species:Drosophila melanogaster
Sequence 2:NP_114183.1 Gene:Src / 83805 RGDID:620795 Length:542 Species:Rattus norvegicus


Alignment Length:505 Identity:145/505 - (28%)
Similarity:217/505 - (42%) Gaps:123/505 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   209 TLVVNSTGSMHCKYL--SDLTSKKAWIFVPCHGMTNCSNNRSIIAEDKDQLDFVNVRMEQ--EGW 269
            :|....||.:...|:  ||....:.|.|   ..:|...:.|.::..:..:..|: ||..:  :|.
  Rat   132 SLSTGQTGYIPSNYVAPSDSIQAEEWYF---GKITRRESERLLLNAENPRGTFL-VRESETTKGA 192

  Fly   270 YTCVESNSLGQSNSTAYLRV----VRSLHVLEAGVASGSLHSTSFVYIFVFGGLIFIFMTTLFVF 330
            | |:   |:...::...|.|    :|.|.       ||..:.||...        |..:..|..:
  Rat   193 Y-CL---SVSDFDNAKGLNVKHYKIRKLD-------SGGFYITSRTQ--------FNSLQQLVAY 238

  Fly   331 YAIRKMKHEKVLKQRIETVHQWTKKVIIFKPEGGGDSSGSMDTMIMPVVRIQKQRTTVLQNGNEP 395
            |:    ||...|..|:.||...:      ||:..|.:..:                         
  Rat   239 YS----KHADGLCHRLTTVCPTS------KPQTQGLAKDA------------------------- 268

  Fly   396 APFNEYEFPLDSNWELPRSHLVLGATLGEGAFGRVVMAEVNNAI-VAVKMVKEGHTDDDIASLVR 459
                         ||:||..|.|...||:|.||.|.|...|... ||:|.:|.|....:  :.::
  Rat   269 -------------WEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPE--AFLQ 318

  Fly   460 EMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFL------YKNRPFGRDQDRDSSQ 518
            |.:|||.: ||..::.|....|:. |:|::.||...|:|.|||      |...|           
  Rat   319 EAQVMKKL-RHEKLVQLYAVVSEE-PIYIVTEYMNKGSLLDFLKGETGKYLRLP----------- 370

  Fly   519 PPPSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQS 583
                         .|:..:.|||.||.|:.....:||||.|.|:||.::.|.|:|||||||.|:.
  Rat   371 -------------QLVDMSAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIED 422

  Fly   584 TDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLM 648
            .:|..:. ..:.||||.|||:.....:..||||||:||||.|:.|.|:.|||.:::.|.| ..:.
  Rat   423 NEYTARQ-GAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVL-DQVE 485

  Fly   649 SGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKLLQTKEDY 698
            .|.||..|.:|..:::.||.|||....::||.|    ||:...|   |||
  Rat   486 RGYRMPCPPECPESLHDLMCQCWRKEPEERPTF----EYLQAFL---EDY 528

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
htlNP_524394.2 Ig 101..191 CDD:472250
Ig strand B 121..125 CDD:409353
Ig strand C 134..138 CDD:409353
Ig strand E 157..161 CDD:409353
Ig strand F 171..176 CDD:409353
Ig strand G 184..187 CDD:409353
Ig 200..289 CDD:472250 18/83 (22%)
Ig strand B 216..220 CDD:409353 1/3 (33%)
Ig strand C 229..233 CDD:409353 0/3 (0%)
Ig strand E 255..259 CDD:409353 0/3 (0%)
Ig strand F 269..274 CDD:409353 2/4 (50%)
Ig strand G 282..285 CDD:409353 0/2 (0%)
Protein Kinases, catalytic domain 404..692 CDD:473864 104/294 (35%)
SrcNP_114183.1 PTKc_Src 266..542 CDD:270656 108/338 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..49
SH3_Src 88..149 CDD:212941 4/16 (25%)
SH2_Src_Src 153..253 CDD:198228 26/126 (21%)
Blue background indicates that the domain is not in the aligned region.

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