DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment htl and THE1

DIOPT Version :9

Sequence 1:	NP_524394.2	Gene:	htl / 42160	FlyBaseID:	FBgn0010389	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_200249.1	Gene:	THE1 / 835526	AraportID:	AT5G54380	Length:	855	Species:	Arabidopsis thaliana

Alignment Length:	867	Identity:	175/867 - (20%)
Similarity:	295/867 - (34%)	Gaps:	293/867 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 SWRASHSTITMTSGSLVVL------------------------FLLLS--------IWQPAVQVE 38
            :|..:.::||:.:...|:|                        ||.||        ::..|::|
plant   116 TWNLTSASITVVTEDFVLLNNFSFNNFNGSYIFKEYTVNVTSEFLTLSFIPSNNSVVFVNAIEV- 179

  Fly    39 GRRQMANSQEMIKDHLGARSQNKTP---------AITNNANQSSTSSADLDDGAADDDDNKAD-L 93
                ::....:|.|...|.:.: ||         ......|.........:|......||.|: |
plant   180 ----VSVPDNLIPDQALALNPS-TPFSGLSLLAFETVYRLNMGGPLLTSQNDTLGRQWDNDAEYL 239

  Fly    94 PVNVSSKPYWRNPKKMSF-----LQTRPS---GSLLTLNCHALGNPEPNITWYRNGTVDWTRGYG 150
            .||.|......||..:.:     .:|.|:   .:..|:....:.:|..|:||
plant   240 HVNSSVLVVTANPSSIKYSPSVTQETAPNMVYATADTMGDANVASPSFNVTW------------- 291

  Fly   151 SLKRNRWTLTMEDLVPGDCG-NYTCKV--CNSLGCIRHDTQVIVSDRVNH-------KPILMTGP 205
                         ::|.|.. .|..:|  |:           |||..:|.       ...|..|.
plant   292 -------------VLPVDPDFRYFVRVHFCD-----------IVSQALNTLVFNLYVNDDLALGS 332

  Fly   206 LNLTLVVNSTGSMHCKYLSDLTSKKAWIFVPCHGMTNCSNNRSIIAEDKDQLDFVNVRMEQEGWY 270
            |:|:.:.|   .:...|..|..|         :|....|...::......|.|..|..|
plant   333 LDLSTLTN---GLKVPYFKDFIS---------NGSVESSGVLTVSVGPDSQADITNATM------ 379

  Fly   271 TCVESNSLGQSNSTAYLRVVRSLHVLEAGVASGSLHSTSFVYIFVFGGLIFIFMTTLFVFYAIRK 335
                                ..|.||:....:.||...|.|...:.||             :..|
plant   380 --------------------NGLEVLKISNEAKSLSGVSSVKSLLPGG-------------SGSK 411

  Fly   336 MKHEKVLKQRIETVHQWTKKVIIFKPEGGGDSSGSMDTMIMPV--------VRIQKQRTTVLQNG 392
            .|                ||.:|.     |...|:: |:|:.:        |..:|||:|..|.|
plant   412 SK----------------KKAVII-----GSLVGAV-TLILLIAVCCYCCLVASRKQRSTSPQEG 454

  Fly   393 NEPAPFNEYEFPLD--------------------SNWELPRSHL--------VLGAT-------- 421
            ....|:    .||.                    |...|..:||        ::.||
plant   455 GNGHPW----LPLPLYGLSQTLTKSTASHKSATASCISLASTHLGRCFMFQEIMDATNKFDESSL 515

  Fly   422 LGEGAFGRVVMAEVNNAIVAVKMVKEGH--TDDDIASLVREMEVMKIIGRHINIINLLGCCSQNG 484
            ||.|.||||....:.:.....  ||.|:  ::..:|....|:|::..: ||.::::|:|.|.:..
plant   516 LGVGGFGRVYKGTLEDGTKVA--VKRGNPRSEQGMAEFRTEIEMLSKL-RHRHLVSLIGYCDERS 577

  Fly   485 PLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMDYL-- 547
            .:.::.||..:|.|:..||     |.|          .||   ::.|..::.....|||:.||
plant   578 EMILVYEYMANGPLRSHLY-----GAD----------LPP---LSWKQRLEICIGAARGLHYLHT 624

  Fly   548 -ASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYD 611
             ||:..||||:...|:|:.::.|.|:|||||::...|.|....:|..:....::.||..:.:...
plant   625 GASQSIIHRDVKTTNILLDENLVAKVADFGLSKTGPSLDQTHVSTAVKGSFGYLDPEYFRRQQLT 689

  Fly   612 SKSDVWSYGILLWEIMTYGQQ-----PYPTIMSAEELYTYLMSG---QRMEKPAKCSMNIYILMR 668
            .||||:|:|::|.|::.....     |...:..||....:...|   |.|:......:|...|.:
plant   690 EKSDVYSFGVVLMEVLCCRPALNPVLPREQVNIAEWAMAWQKKGLLDQIMDSNLTGKVNPASLKK 754

  Fly   669 ------QCWHFNADDRPPFTEI---VEYMDKLLQTKEDYLD------------------------ 700
                  :|......|||...::   :||..:|.:|....::
plant   755 FGETAEKCLAEYGVDRPSMGDVLWNLEYALQLEETSSALMEPDDNSTNHIPGIPMAPMEPFDNSM 819

  Fly   701 --VDIANLDTPPSTSDEEEDET 720
              :|...:::...|.|:.||.|
plant   820 SIIDRGGVNSGTGTDDDAEDAT 841

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	112..191	CDD:299845	12/84 (14%)
		IG_like	113..191	CDD:214653	12/83 (14%)
		IG_like	205..289	CDD:214653	12/83 (14%)
		PKc_like	404..692	CDD:304357	84/345 (24%)
		STYKc	416..688	CDD:214568	78/309 (25%)
THE1	NP_200249.1	Malectin_like	34..384	CDD:289580	58/348 (17%)
		Malectin	210..382	CDD:288557	41/246 (17%)
		STKc_IRAK	516..781	CDD:270968	74/285 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	98	1.000	Inparanoid score	I2197
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.960