DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment htl and AT3G46340

DIOPT Version :9

Sequence 1:	NP_524394.2	Gene:	htl / 42160	FlyBaseID:	FBgn0010389	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_190218.1	Gene:	AT3G46340 / 823779	AraportID:	AT3G46340	Length:	889	Species:	Arabidopsis thaliana

Alignment Length:	785	Identity:	165/785 - (21%)
Similarity:	274/785 - (34%)	Gaps:	282/785 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 SSKPYWRNPKKMSFLQTRP---------SGSLLTLNCHALGNPEPNITWYRNGTVD--WTRGYGS 151
            :|.|:      :|.|:.||         ||||.|...:.|.|.| ::..|.....|  |...:.|
plant   170 TSTPF------LSLLELRPLDNDSYLTGSGSLKTFRRYYLSNSE-SVIAYPEDVKDRIWEPTFDS 227

  Fly   152 LKRNRWTLTMEDLVPGDCGNYTCKVCNSLGCIRHDTQVIVSDRVNHKPILMT--------GPLNL 208
            ..:..||              |.|..||.|.:            ..|.:|||        .|...
plant   228 EWKQIWT--------------TLKPNNSNGYL------------VPKNVLMTAAIPANDSAPFRF 266

  Fly   209 TLVVNSTGSMHCKYL--SDLTSKKA---------W-------IFVP---------------CHG- 239
            |..::|.......||  |::.|.:|         |       .|:|               |.|
plant   267 TEELDSPTDELYVYLHFSEVQSLQANESREFDILWSGEVAYEAFIPEYLNITTIQTNTPVTCPGG 331

  Fly   240 -------MTNCSNNRSIIAE------------DKDQLDFVNVR-------MEQEGWY--TCVESN 276
                   .|..|.:..:|..            :.::.|.|.::       :.:..|.  .||...
plant   332 KCNLELKRTKNSTHPPLINAIEFYTVVNFPQLETNETDVVAIKDIKATYELNRITWQGDPCVPQK 396

  Fly   277 SLGQS---NSTAYLRVVR--SLHVLEAG----VASGSLHSTSFVYI-----FVFGGL-IFIFMTT 326
            .:.:.   ||...|.:.|  ||::...|    :|:|..:.|....:     .:.||: .|:....
plant   397 FIWEGLDCNSKDALTLPRITSLNLSSTGLTGNIAAGIQNLTHLDKLDLSNNNLTGGVPEFLASMK 461

  Fly   327 LFVFYAIRK-----------MKHEK-VLKQRI-ETVHQWTKKVIIFKPEGGGDSSGSMDTMIMPV 378
            ...|..:.|           :|.|| .||..: |.:..:....:|.|.:        ...||:.:
plant   462 SLSFINLSKNNLNGSIPQALLKREKDGLKLSVDEQIRCFPGSCVITKKK--------FPVMIVAL 518

  Fly   379 VR---------------IQKQRTTVLQNGNEPAPFNEYEFPLDSNWELPRSHLV----------- 417
            |.               .:|::           |.|..:.|..||  .||.::.
plant   519 VSSAVVVILVVLVLIFVFKKKK-----------PSNLEDLPPSSN--TPRENITSTSISDTSIET 570

  Fly   418 ----------------LGATLGEGAFGRVVMAEVNNAI--VAVKMVKEGHTDDDIASLVREMEVM 464
                            |...||||.||.|...::|.:.  ||||::.:..| ........|:|::
plant   571 KRKRFSYSEVMEMTKNLQRPLGEGGFGVVYHGDINGSSQQVAVKLLSQSST-QGYKEFKAEVELL 634

  Fly   465 KIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPSPPAHVIT 529
            ..: .|||:::|:|.|.:...|.:|.||..:.:||..|             |.:...|    |:.
plant   635 LRV-HHINLVSLVGYCDERDHLALIYEYMSNKDLKHHL-------------SGKHGGS----VLK 681

  Fly   530 EKDLIKFAHQIARGMDYL---ASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNT 591
            ....::.|...|.|::||   .....:|||:.:.|:|:.|.:..|:|||||:|..|..|..:.:|
plant   682 WNTRLQIAVDAALGLEYLHIGCRPSMVHRDVKSTNILLDDQFTAKMADFGLSRSFQLGDESQVST 746

  Fly   592 NGRLPIKWMAPESLQEKFYDS-----KSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQ 651
                 :....|..|..::|.:     .|||:|:||:|.||:|                     .|
plant   747 -----VVAGTPGYLDPEYYRTGRLAEMSDVYSFGIVLLEIIT---------------------NQ 785

  Fly   652 RMEKPAKCSMNI-----YILMRQCWHFNADDRPPFTEIVEYMDKLLQ----TKEDYLDVDIANLD 707
            |:..||:...:|     ::|.|             .:|...||..||    ::..:..:::|.:.
plant   786 RVIDPAREKSHITEWTAFMLNR-------------GDITRIMDPNLQGDYNSRSVWRALELAMMC 837

  Fly   708 TPPST 712
            ..||:
plant   838 ANPSS 842

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	112..191	CDD:299845	22/89 (25%)
		IG_like	113..191	CDD:214653	21/88 (24%)
		IG_like	205..289	CDD:214653	24/148 (16%)
		PKc_like	404..692	CDD:304357	81/329 (25%)
		STYKc	416..688	CDD:214568	74/313 (24%)
AT3G46340	NP_190218.1	Malectin_like	35..357	CDD:372329	45/219 (21%)
		PLN00113	340..>482	CDD:215061	23/141 (16%)
		leucine-rich repeat	415..438	CDD:275380	5/22 (23%)
		leucine-rich repeat	439..462	CDD:275380	3/22 (14%)
		STKc_IRAK	591..857	CDD:270968	80/310 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	98	1.000	Inparanoid score	I2197
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050