DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment htl and HERK1

DIOPT Version :9

Sequence 1:	NP_524394.2	Gene:	htl / 42160	FlyBaseID:	FBgn0010389	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_190214.1	Gene:	HERK1 / 823774	AraportID:	AT3G46290	Length:	830	Species:	Arabidopsis thaliana

Alignment Length:	474	Identity:	108/474 - (22%)
Similarity:	195/474 - (41%)	Gaps:	102/474 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   275 SNSLGQSNSTAYLRVVRSLHVLEAGVASGSLHSTSFVYIFVFGGLI-FIFMTTLFVFYAIRKM-- 336
            :||.||.::..::          .|.:|.|..:...:.....|.|: .:|:.:.||.|..||.
plant   381 NNSKGQLSTGTFV----------PGSSSSSKSNLGLIVGSAIGSLLAVVFLGSCFVLYKKRKRGQ 435

  Fly   337 -KHEKVLKQRIETVHQWTKKVIIFKPEGGGDSSGSMDTMIMPVVRIQKQRTTVLQNGNEPAPFNE 400
             .|.|.          |....|.....|...|:|:  |:           |::..|.|...||..
plant   436 DGHSKT----------WMPFSINGTSMGSKYSNGT--TL-----------TSITTNANYRIPFAA 477

  Fly   401 YEFPLDSNWELPRSHLVLGATLGEGAFGRVVMAEVNNAIVAVKMVKEGH--TDDDIASLVREMEV 463
            .: ...:|::..|:       :|.|.||:|...|:|:.....  ||.|:  :...:|....|:|:
plant   478 VK-DATNNFDESRN-------IGVGGFGKVYKGELNDGTKVA--VKRGNPKSQQGLAEFRTEIEM 532

  Fly   464 MKIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPSPPAHVI 528
            :... ||.::::|:|.|.:|..:.:|.||..:|.:|..||           .|..|.       :
plant   533 LSQF-RHRHLVSLIGYCDENNEMILIYEYMENGTVKSHLY-----------GSGLPS-------L 578

  Fly   529 TEKDLIKFAHQIARGMDYL---ASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKN 590
            |.|..::.....|||:.||   .|:..||||:.:.|:|:.::::.|:|||||::.....|....:
plant   579 TWKQRLEICIGAARGLHYLHTGDSKPVIHRDVKSANILLDENFMAKVADFGLSKTGPELDQTHVS 643

  Fly   591 TNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEK 655
            |..:....::.||..:.:....||||:|:|::|:|::.......||:  ..|:........:.:|
plant   644 TAVKGSFGYLDPEYFRRQQLTDKSDVYSFGVVLFEVLCARPVIDPTL--PREMVNLAEWAMKWQK 706

  Fly   656 PAKCSMNIYILMR----------------QCWHFNADDRPPFTEIVEYMDKLLQTKEDYLDVDIA 704
            ..:....|...:|                :|......|||...:::..::..||.:|..:|
plant   707 KGQLDQIIDQSLRGNIRPDSLRKFAETGEKCLADYGVDRPSMGDVLWNLEYALQLQEAVID---- 767

  Fly   705 NLDTPPSTSDEEEDETDNL 723
                     .|.||.:.|:
plant   768 ---------GEPEDNSTNM 777

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	112..191	CDD:299845
		IG_like	113..191	CDD:214653
		IG_like	205..289	CDD:214653	4/13 (31%)
		PKc_like	404..692	CDD:304357	72/308 (23%)
		STYKc	416..688	CDD:214568	70/292 (24%)
HERK1	NP_190214.1	Malectin_like	33..380	CDD:372329
HERK1	NP_190214.1	STKc_IRAK	491..756	CDD:270968	70/287 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	98	1.000	Inparanoid score	I2197
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.960