DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment htl and AT2G23200

DIOPT Version :9

Sequence 1:	NP_524394.2	Gene:	htl / 42160	FlyBaseID:	FBgn0010389	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_179901.1	Gene:	AT2G23200 / 816852	AraportID:	AT2G23200	Length:	834	Species:	Arabidopsis thaliana

Alignment Length:	780	Identity:	165/780 - (21%)
Similarity:	283/780 - (36%)	Gaps:	246/780 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 TITMTSGSLVVLFLLLSIWQP-----AVQVEGRRQMANSQE----MIKDHLGARSQNKTPAITNN 68
            |::.||||    ...|..:.|     ..:||....|.||.|    .:.||        :.....|
plant   131 TVSATSGS----NHHLKSFSPQNLTNTPRVEEFLLMMNSLEFEIRFVPDH--------SSLALIN 183

  Fly    69 ANQSSTSSADLDDGAADDDDNKADLPVNVSSKPYWRNPKKMSFLQTRPSGSLLTLNCHALGN--- 130
            |.:..::..||:..:|.|.:......:||                   .|..:|.:...||.
plant   184 AIEVFSAPDDLEIPSASDKNLHTIYRLNV-------------------GGEKITPDNDTLGRTWL 229

  Fly   131 PEPNITWYRNGTVDWTRGYGSLKRNRWTLTMEDLVPGDCGNYTCKVCNSLGCIRHDTQVIVSDRV 195
            |:.:...||.   |..|...|.:...:...:.........::..|...::            :|.
plant   230 PDDDDFLYRK---DSARNINSTQTPNYVGGLSSATDSTAPDFVYKTAKAM------------NRS 279

  Fly   196 NHKPILMTGPLNLTLVVNSTGSMHCK---------YLSDLTSKKAWIFVPCHGMTNCSNNRSIIA 251
            :::.:.|        ::|.|.|...|         :.||:             ::|.||:
plant   280 SNEQVGM--------LMNVTWSFKVKSNHRHFIRIHFSDI-------------LSNLSNS----- 318

  Fly   252 EDKDQLDFVNVRMEQEG-WYTCVESN-------------------------SLG--QSNSTA-YL 287
             |.|...|||      | |...|:.:                         |:|  ::|..| :|
plant   319 -DSDFYLFVN------GYWRVDVKPSEQPRLASPFFKDVVNVSDGSGLLNISIGTKEANKDAGFL 376

  Fly   288 RVVRSLHVLEAGVASGSLHSTSFVYIF--------VFGGLIFIFMTTLFVFYAIRKMKHEKVLKQ 344
            ..:..:.||....:..|..|:|.|:|.        ....|:|..:..:|:     |.:..|..|.
plant   377 NGLEMMEVLSKSGSDYSNRSSSRVHIITGCAVAAAAASALVFSLLFMVFL-----KRRRSKKTKP 436

  Fly   345 RIE-TVHQWTKKVIIFKPEGGGDSSGSMDTMIMPVVRIQKQRTTVLQNGNEPAPFNEYEFPLDSN 408
            .:| ||  |:...:    ..||.|                          :..|.::|.     |
plant   437 EVEGTV--WSPLPL----HRGGSS--------------------------DNRPISQYH-----N 464

  Fly   409 WELPRSHL--------VLGAT--------LGEGAFGRVVMAEV-NNAIVAVKMVKEGHTDDDIAS 456
            ..|...||        :|.||        :|:|.||.|..|.: :....|:|..|.| :...|..
plant   465 SPLRNLHLGLTIPFTDILSATNNFDEQLLIGKGGFGYVYKAILPDGTKAAIKRGKTG-SGQGILE 528

  Fly   457 LVREMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLY-KNRPFGRDQDRDSSQPP 520
            ...|::|:..| ||.::::|.|.|.:|..:.::.|:...|.||:.|| .|.|
plant   529 FQTEIQVLSRI-RHRHLVSLTGYCEENSEMILVYEFMEKGTLKEHLYGSNLP------------- 579

  Fly   521 PSPPAHVITEKDLIKFAHQIARGMDYLASR----RCIHRDLAARNVLVSDDYVLKIADFGLARDI 581
                  .:|.|..::.....|||:|||.|.    ..||||:.:.|:|:.:..:.|:|||||:: |
plant   580 ------SLTWKQRLEICIGAARGLDYLHSSGSEGAIIHRDVKSTNILLDEHNIAKVADFGLSK-I 637

  Fly   582 QSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQ---QPY--------- 634
            .:.|....:.|.:....::.||.||......||||:::|::|.|:: :.:   .||
plant   638 HNQDESNISINIKGTFGYLDPEYLQTHKLTEKSDVYAFGVVLLEVL-FARPAIDPYLPHEEVNLS 701

  Fly   635 PTIM------SAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKLLQ 693
            ..:|      :.:|:....:.||......|..|.|   ..:|.....|:||...:::..::.:||
plant   702 EWVMFCKSKGTIDEILDPSLIGQIETNSLKKFMEI---AEKCLKEYGDERPSMRDVIWDLEYVLQ 763

Fly 694 693
plant 764 763

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	112..191	CDD:299845	11/81 (14%)
		IG_like	113..191	CDD:214653	11/80 (14%)
		IG_like	205..289	CDD:214653	22/121 (18%)
		PKc_like	404..692	CDD:304357	83/327 (25%)
		STYKc	416..688	CDD:214568	80/311 (26%)
AT2G23200	NP_179901.1	Malectin_like	41..383	CDD:289580	58/330 (18%)
		STKc_IRAK	494..759	CDD:270968	76/290 (26%)
		TyrKc	494..758	CDD:197581	76/289 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	98	1.000	Inparanoid score	I2197
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050