DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment htl and Fgfr1

DIOPT Version :10

Sequence 1:NP_524394.2 Gene:htl / 42160 FlyBaseID:FBgn0010389 Length:729 Species:Drosophila melanogaster
Sequence 2:NP_077060.2 Gene:Fgfr1 / 79114 RGDID:620713 Length:822 Species:Rattus norvegicus


Alignment Length:790 Identity:297/790 - (37%)
Similarity:424/790 - (53%) Gaps:100/790 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 AAAWSWRASHSTITMTSGSLVVLFLLL-----SI-W-QPAVQV-EGRRQMANSQEM-IKDHLGAR 57
            |..|.......::.:..|.|:.|...|     || | :..||: |..|.....:|: ::|.:.|.
  Rat    31 AQPWGVPVEVESLLVHPGDLLQLRCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVRDSIPAD 95

  Fly    58 SQNKTPAITNNANQSSTS-----------SADLDDGAADDDDNKADLPVNVSSK-------PYWR 104
            | .....:||:.:.|.|:           |::.||   ||||:.::.....::|       |||.
  Rat    96 S-GLYACVTNSPSGSDTTYFSVNVSDALPSSEDDD---DDDDSSSEEKETDNTKPNRRPVAPYWT 156

  Fly   105 NPKKM-SFLQTRPSGSLLTLNCHALGNPEPNITWYRNG---TVDWTRGYGSLKRNRWTLTMEDLV 165
            :|:|| ..|...|:...:...|.:.|.|.|.:.|.:||   ..|...|...::...|::.|:.:|
  Rat   157 SPEKMEKKLHAVPAAKTVKFKCPSSGTPSPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVV 221

  Fly   166 PGDCGNYTCKVCNSLGCIRHDTQVIVSDRVNHKPILMTG-PLNLTLVVNSTGSMHCKYLSDLTSK 229
            |.|.|||||.|.|..|.|.|..|:.|.:|..|:|||..| |.|.|:.:.|.....||..||....
  Rat   222 PSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPH 286

  Fly   230 KAWI-FVPCHGMTNCSNN---------RSIIAEDKDQ--LDFVNVRMEQEGWYTCVESNSLGQSN 282
            ..|: .:..:|.....:|         ..:...||:.  |...||..|..|.|||:..||:|.|:
  Rat   287 IQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSH 351

  Fly   283 STAYLRVVRSLHVLEAGVASGSLHSTSFVYIFVFGGLIFIFMTTLFVFYAIRKMK--------HE 339
            .:|:|.|:.:|....| |.:..|:..  :.|:..|..:...|....:.|   |||        |.
  Rat   352 HSAWLTVLEALEERPA-VMTSPLYLE--IIIYCTGAFLISCMVGSVIIY---KMKSGTKKSDFHS 410

  Fly   340 KVLKQRIETVHQWTKKVIIFKP-EGGGDSSGSMDTMIMPVVRIQKQRTTVLQNGNEP--APFNEY 401
            ::      .||:..|.:.:.:. ....|||.||::.::.|      |.:.|.:...|  |..:||
  Rat   411 QM------AVHKLAKSIPLRRQVTVSADSSASMNSGVLLV------RPSRLSSSGTPMLAGVSEY 463

  Fly   402 EFPLDSNWELPRSHLVLGATLGEGAFGRVVMAEV-------NNAI--VAVKMVKEGHTDDDIASL 457
            |.|.|..|||||..||||..||||.||:||:||.       .|.:  |||||:|...|:.|::.|
  Rat   464 ELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDL 528

  Fly   458 VREMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPS 522
            :.|||:||:||:|.|||||||.|:|:||||||||||..|||:::|...||.|.:.    ...|..
  Rat   529 ISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEY----CYNPSH 589

  Fly   523 PPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYY 587
            .|...::.|||:..|:|:||||:||||::|||||||||||||::|.|:|||||||||||...|||
  Rat   590 NPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYY 654

  Fly   588 RKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQR 652
            :|.||||||:||||||:|.::.|..:|||||:|:|||||.|.|..|||.: ..|||:..|..|.|
  Rat   655 KKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGV-PVEELFKLLKEGHR 718

  Fly   653 MEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKL--LQTKEDYLDVDI-------ANLDT 708
            |:||:.|:..:|::||.|||.....||.|.::||.:|::  |.:.::|||:.:       :..||
  Rat   719 MDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDT 783

  Fly   709 PPSTSDEEED 718
            ..||....||
  Rat   784 RSSTCSSGED 793

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
htlNP_524394.2 Ig 101..191 CDD:472250 33/93 (35%)
Ig strand B 121..125 CDD:409353 0/3 (0%)
Ig strand C 134..138 CDD:409353 0/3 (0%)
Ig strand E 157..161 CDD:409353 1/3 (33%)
Ig strand F 171..176 CDD:409353 4/4 (100%)
Ig strand G 184..187 CDD:409353 1/2 (50%)
Ig 200..289 CDD:472250 30/101 (30%)
Ig strand B 216..220 CDD:409353 0/3 (0%)
Ig strand C 229..233 CDD:409353 0/3 (0%)
Ig strand E 255..259 CDD:409353 1/5 (20%)
Ig strand F 269..274 CDD:409353 3/4 (75%)
Ig strand G 282..285 CDD:409353 0/2 (0%)
Protein Kinases, catalytic domain 404..692 CDD:473864 162/298 (54%)
Fgfr1NP_077060.2 IgI_1_FGFR 25..118 CDD:409362 21/87 (24%)
Ig strand A 25..28 CDD:409362
Ig strand A' 40..46 CDD:409362 0/5 (0%)
Ig strand B 49..59 CDD:409362 3/9 (33%)
Ig strand C 63..68 CDD:409362 3/4 (75%)
Ig strand C' 71..73 CDD:409362 1/1 (100%)
Ig strand D 78..82 CDD:409362 1/3 (33%)
Ig strand E 85..90 CDD:409362 1/4 (25%)
Ig strand F 96..105 CDD:409362 2/9 (22%)
Ig strand G 108..118 CDD:409362 2/9 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 120..162 13/44 (30%)
IgI_2_FGFR 153..247 CDD:409443 33/93 (35%)
Ig strand A 153..156 CDD:409443 2/2 (100%)
Heparin-binding 160..177 4/16 (25%)
Ig strand A' 164..169 CDD:409443 1/4 (25%)
Ig strand B 173..181 CDD:409443 1/7 (14%)
Ig strand C 187..192 CDD:409443 1/4 (25%)
Ig strand C' 195..197 CDD:409443 0/1 (0%)
Ig strand D 206..209 CDD:409443 0/2 (0%)
Ig strand E 213..218 CDD:409443 1/4 (25%)
Ig strand F 227..234 CDD:409443 5/6 (83%)
Ig strand G 237..247 CDD:409443 4/9 (44%)
Ig 255..359 CDD:472250 31/103 (30%)
Ig strand B 273..277 CDD:409444 0/3 (0%)
Ig strand C 286..290 CDD:409444 0/3 (0%)
Ig strand E 324..328 CDD:409444 1/3 (33%)
Ig strand F 338..343 CDD:409444 3/4 (75%)
Ig strand G 351..354 CDD:409444 0/2 (0%)
PTKc_FGFR1 464..765 CDD:270678 164/305 (54%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 770..822 6/24 (25%)
Blue background indicates that the domain is not in the aligned region.

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