Protein Alignment htl and ZAP70

DIOPT Version :10

• Sequence 1: NP_524394.2
• Gene: htl / 42160
• FlyBaseID: FBgn0010389
• Length: 729
• Species: Drosophila melanogaster
• Sequence 2: XP_054188971.1
• Gene: ZAP70 / 7535
• HGNCID: 12858
• Length: 707
• Species: Homo sapiens
• Alignment Length: 765
• Identity: 187/765 - (24%)
• Similarity: 303/765 - (39%)
• Gaps: 218/765 - (28%)

  Fly    93 LPVN--VSSKPYWRNPKKMSFLQTRPS------------------GSLLTLN-------C---H- 126
            :|.|  ||.||..|     |...||||                  ||.|.|.       |   |
Human    17 VPGNRLVSDKPACR-----SSADTRPSGQAWPTVGLRAAAGAFRTGSPLALGPETPQVACLPGHP 76

  Fly   127 -----------ALGNPEPNITWYRNGTVDWTRGYGSLKRNRWTLTMEDLVPGDCGNYTCKVC-NS 179
                       |:.:|..::.::          |||:.|......::.....| |.:..:.| .|
Human    77 PVRPQVSGGPGAMPDPAAHLPFF----------YGSISRAEAEEHLKLAGMAD-GLFLLRQCLRS 130

  Fly   180 LG----CIRHDTQVIVSDRVNHKPILMTGPLNLTLVVNSTGSMHCK-------YLSDLTSKKAWI 233
            ||    .:.||.      |.:|.||  ...||.|..: :.|..||.       |..|.......:
Human   131 LGGYVLSLVHDV------RFHHFPI--ERQLNGTYAI-AGGKAHCGPAELCEFYSRDPDGLPCNL 186

  Fly   234 FVPCH---------GMTNCSNNRSIIAEDKDQLDFVNVRMEQEGWYTCVESNSLGQS-------N 282
            ..||:         |:.:|..:..:       .|:|....:.||  ..:|...:.|:       .
Human   187 RKPCNRPSGLEPQPGVFDCLRDAMV-------RDYVRQTWKLEG--EALEQAIISQAPQVEKLIA 242

  Fly   283 STAYLRVVRSLHVLEAGVASGSLHS----------------TSFVYIFVFGGLIFIFMTTLFVFY 331
            :||:.|:......|....|...|:|                .::....::|..::        .|
Human   243 TTAHERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKEQGTYALSLIYGKTVY--------HY 299

  Fly   332 AIRKMKHEK----------VLKQRIETVHQWTKKVIIFKPEGGGDSSGS-------------MDT 373
            .|.:.|..|          .|.|.:|.:......:|....|...:||.|             ..|
Human   300 LISQDKAGKYCIPEGTKFDTLWQLVEYLKLKADGLIYCLKEACPNSSASNASGAAAPTLPAHPST 364

  Fly   374 MIMPVVRIQKQRTTVLQNGNEP------APFNEYEFPLDSN-WELPRSH---------------- 415
            :..|    |::..|:..:|..|      :|......|:|:: :|.|.|.
Human   365 LTHP----QRRIDTLNSDGYTPEPARITSPDKPRPMPMDTSVYESPYSDPEELKDKKLFLKRDNL 425

  Fly   416 LVLGATLGEGAFG-------RVVMAEVNNAIVAVKMVKEGHTDDDIASLVREMEVMKIIGRHINI 473
            |:....||.|.||       |:...:::   ||:|::|:|....|...::||.::|..:.... |
Human   426 LIADIELGCGNFGSVRQGVYRMRKKQID---VAIKVLKQGTEKADTEEMMREAQIMHQLDNPY-I 486

  Fly   474 INLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPSPPAHVITEKDLIKFAH 538
            :.|:|.| |...|.:::|.|..|.|..||...|          .:.|.|..|.::         |
Human   487 VRLIGVC-QAEALMLVMEMAGGGPLHKFLVGKR----------EEIPVSNVAELL---------H 531

  Fly   539 QIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTD-YYRKNTNGRLPIKWMAP 602
            |::.||.||..:..:||||||||||:.:.:..||:||||::.:.:.| ||...:.|:.|:||.||
Human   532 QVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAP 596

  Fly   603 ESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILM 667
            |.:..:.:.|:|||||||:.:||.::|||:||.. |...|:..::..|:|||.|.:|...:|.||
Human   597 ECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKK-MKGPEVMAFIEQGKRMECPPECPPELYALM 660

  Fly   668 RQCWHFNADDRPPFTEIVEYMDKLLQTKEDYLDVDIANLDTPPSTSDEEE 717
            ..||.:..:|||.|..:.:.|      :..|..: .:.::.||.::.:.|
Human   661 SDCWIYKWEDRPDFLTVEQRM------RACYYSL-ASKVEGPPGSTQKAE 703

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	101..191	CDD:472250	27/134 (20%)
		Ig strand B	121..125	CDD:409353	2/10 (20%)
		Ig strand C	134..138	CDD:409353	0/3 (0%)
		Ig strand E	157..161	CDD:409353	0/3 (0%)
		Ig strand F	171..176	CDD:409353	0/4 (0%)
		Ig strand G	184..187	CDD:409353	1/2 (50%)
		Ig	200..289	CDD:472250	21/111 (19%)
		Ig strand B	216..220	CDD:409353	1/3 (33%)
		Ig strand C	229..233	CDD:409353	0/3 (0%)
		Ig strand E	255..259	CDD:409353	0/3 (0%)
		Ig strand F	269..274	CDD:409353	0/4 (0%)
		Ig strand G	282..285	CDD:409353	0/2 (0%)
		Protein Kinases, catalytic domain	404..692	CDD:473864	102/312 (33%)
ZAP70	XP_054188971.1	SH2_N-SH2_Zap70_Syk_like	96..199	CDD:198191	26/122 (21%)
		SH2_C-SH2_Zap70	240..343	CDD:198265	17/110 (15%)
		PTKc_Zap-70	421..689	CDD:270686	98/299 (33%)