DRSC/TRiP Functional Genomics Resources

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Protein Alignment htl and YES1

DIOPT Version :10

Sequence 1:NP_524394.2 Gene:htl / 42160 FlyBaseID:FBgn0010389 Length:729 Species:Drosophila melanogaster
Sequence 2:NP_005424.1 Gene:YES1 / 7525 HGNCID:12841 Length:543 Species:Homo sapiens


Alignment Length:383 Identity:121/383 - (31%)
Similarity:176/383 - (45%) Gaps:80/383 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   331 YAIRKMKH--------------EKVLKQRIETVHQWTKKVIIFKPEGGGDSSGSMDTMIMPVVRI 381
            |.|||:.:              :|::|...|.......|:                |.:.|.|:.
Human   212 YKIRKLDNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKL----------------TTVCPTVKP 260

  Fly   382 QKQRTTVLQNGNEPAPFNEYEFPLDSNWELPRSHLVLGATLGEGAFGRVVMAEVNNAI-VAVKMV 445
            |.|...                  ...||:||..|.|...||:|.||.|.|...|... ||:|.:
Human   261 QTQGLA------------------KDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTL 307

  Fly   446 KEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGR 510
            |.|....:  :.::|.::||.: ||..::.|....|:. |:|::.|:...|:|.|||       :
Human   308 KPGTMMPE--AFLQEAQIMKKL-RHDKLVPLYAVVSEE-PIYIVTEFMSKGSLLDFL-------K 361

  Fly   511 DQDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADF 575
            :.|....:.|           .|:..|.|||.||.|:.....|||||.|.|:||.::.|.|||||
Human   362 EGDGKYLKLP-----------QLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIADF 415

  Fly   576 GLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSA 640
            ||||.|:..:|..:. ..:.||||.|||:.....:..||||||:|||..|::|.|:.|||.:::.
Human   416 GLARLIEDNEYTARQ-GAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNR 479

  Fly   641 EELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKLLQTKEDY 698
            |.| ..:..|.||..|..|..:::.||..||..:.|:||.|    ||:...|   |||
Human   480 EVL-EQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTF----EYIQSFL---EDY 529

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
htlNP_524394.2 Ig 101..191 CDD:472250
Ig strand B 121..125 CDD:409353
Ig strand C 134..138 CDD:409353
Ig strand E 157..161 CDD:409353
Ig strand F 171..176 CDD:409353
Ig strand G 184..187 CDD:409353
Ig 200..289 CDD:472250
Ig strand B 216..220 CDD:409353
Ig strand C 229..233 CDD:409353
Ig strand E 255..259 CDD:409353
Ig strand F 269..274 CDD:409353
Ig strand G 282..285 CDD:409353
Protein Kinases, catalytic domain 404..692 CDD:473864 104/288 (36%)
YES1NP_005424.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..45
SH3_Yes 94..151 CDD:212940
SH2_Src_family 154..253 CDD:199827 8/56 (14%)
PTKc_Yes 264..542 CDD:270654 108/315 (34%)
Blue background indicates that the domain is not in the aligned region.

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