DRSC/TRiP Functional Genomics Resources

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Protein Alignment htl and TXK

DIOPT Version :10

Sequence 1:NP_524394.2 Gene:htl / 42160 FlyBaseID:FBgn0010389 Length:729 Species:Drosophila melanogaster
Sequence 2:XP_024309968.1 Gene:TXK / 7294 HGNCID:12434 Length:530 Species:Homo sapiens


Alignment Length:541 Identity:143/541 - (26%)
Similarity:230/541 - (42%) Gaps:131/541 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   222 YLSDLTSKKAWIFVPCHGMTNCSNNR-------SIIAEDKDQL----DFV-----NVRMEQEGWY 270
            :||.|::||.    ...|....|..:       |.:||:|.|:    ||:     |:.:.:...|
Human    52 WLSQLSNKKQ----SNTGRVQPSKRKPLPPLPPSEVAEEKIQVKALYDFLPREPCNLALRRAEEY 112

  Fly   271 TCVE--------------------SNSLGQSNSTA------YLRVV---RSLHVLE------AGV 300
            ..:|                    ||.:.::..|.      |.|.:   ::.|:|.      |.:
Human   113 LILEKYNPHWWKARDRLGNEGLIPSNYVTENKITNLEIYEWYHRNITRNQAEHLLRQESKEGAFI 177

  Fly   301 ASGSLHSTSFVYIFVFGGLIFIFMTTLFVFYAIRK-----MKHEKVLKQRIETVHQW-------- 352
            ...|.|..|:               |:.||...|:     :||.::.|   ....||        
Human   178 VRDSRHLGSY---------------TISVFMGARRSTEAAIKHYQIKK---NDSGQWYVAERHAF 224

  Fly   353 --TKKVIIFKPEGGGDSSGSMDTMIMPVVRIQKQRTTVLQNGNEPAPFN-EYEFPLDSNWELPRS 414
              ..::|.:...   :::|.|..:..||         .|.....||... .||     .||:..|
Human   225 QSIPELIWYHQH---NAAGLMTRLRYPV---------GLMGSCLPATAGFSYE-----KWEIDPS 272

  Fly   415 HLVLGATLGEGAFGRVVMAEVNNAI-VAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLG 478
            .|.....:|.|.||.|.:.|..:.| ||:|.:.||...::  ..:.|.:||..:. |..::.|.|
Human   273 ELAFIKEIGSGQFGVVHLGEWRSHIQVAIKAINEGSMSEE--DFIEEAKVMMKLS-HSKLVQLYG 334

  Fly   479 CCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPSPPAHVITEKDLIKFAHQIARG 543
            .|.|..|||::.|:..:|.|.::|.:|:  |:                 :.::.|:.....|..|
Human   335 VCIQRKPLYIVTEFMENGCLLNYLRENK--GK-----------------LRKEMLLSVCQDICEG 380

  Fly   544 MDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEK 608
            |:||.....|||||||||.|||...::||:|||:.|.:.. |.|..:...:.||||..||.....
Human   381 MEYLERNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLD-DEYVSSFGAKFPIKWSPPEVFLFN 444

  Fly   609 FYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHF 673
            .|.|||||||:|:|:||:.|.|:.|:.. .|..::...:..|.|:.:|....|:||.:|..|||.
Human   445 KYSSKSDVWSFGVLMWEVFTEGKMPFEN-KSNLQVVEAISEGFRLYRPHLAPMSIYEVMYSCWHE 508

  Fly   674 NADDRPPFTEIVEYMDKLLQT 694
            ..:.||.|.|::..:.::.:|
Human   509 KPEGRPTFAELLRAVTEIAET 529

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
htlNP_524394.2 Ig 101..191 CDD:472250
Ig strand B 121..125 CDD:409353
Ig strand C 134..138 CDD:409353
Ig strand E 157..161 CDD:409353
Ig strand F 171..176 CDD:409353
Ig strand G 184..187 CDD:409353
Ig 200..289 CDD:472250 21/108 (19%)
Ig strand B 216..220 CDD:409353
Ig strand C 229..233 CDD:409353 2/3 (67%)
Ig strand E 255..259 CDD:409353 1/7 (14%)
Ig strand F 269..274 CDD:409353 1/4 (25%)
Ig strand G 282..285 CDD:409353 0/2 (0%)
Protein Kinases, catalytic domain 404..692 CDD:473864 95/288 (33%)
TXKXP_024309968.1 SH3_TXK 88..142 CDD:212840 8/53 (15%)
SH2_Tec_Txk 146..251 CDD:198261 23/134 (17%)
PTKc_Tec_like 269..524 CDD:173637 93/278 (33%)
Blue background indicates that the domain is not in the aligned region.

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