DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment htl and TIE1

DIOPT Version :10

Sequence 1:NP_524394.2 Gene:htl / 42160 FlyBaseID:FBgn0010389 Length:729 Species:Drosophila melanogaster
Sequence 2:NP_005415.1 Gene:TIE1 / 7075 HGNCID:11809 Length:1138 Species:Homo sapiens


Alignment Length:825 Identity:227/825 - (27%)
Similarity:340/825 - (41%) Gaps:225/825 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 WSWRASHSTITMTSGSLVVLFLLLSIWQPAVQVEGRRQMA-NSQEMIKDHLGARSQNKTPAITNN 68
            |..|.|      |||........:::..|.|.:...|.:. .|::::...|.:.|.:...:....
Human   424 WECRVS------TSGGQDSRRFKVNVKVPPVPLAAPRLLTKQSRQLVVSPLVSFSGDGPISTVRL 482

  Fly    69 ANQSSTSSADLDDGAADDDDN--------KADLPVNVS-SKP------YWRNPKKMSFLQTRPSG 118
            ..:...|:.|......|..:|        |....|.|. |:|      .|..|            
Human   483 HYRPQDSTMDWSTIVVDPSENVTLMNLRPKTGYSVRVQLSRPGEGGEGAWGPP------------ 535

  Fly   119 SLLTLNCHALGNPEPNIT-----WYRNGT----VDWTR--------GYGSLKRNRW--------- 157
            :|:|.:|     |||.:.     |:..||    |.|:.        |.|.|.| .|         
Human   536 TLMTTDC-----PEPLLQPWLEGWHVEGTDRLRVSWSLPLVPGPLVGDGFLLR-LWDGTRGQERR 594

  Fly   158 ---------TLTMEDLVPGDCGNYTCKV----CNSLG----------------CIRHDTQVIVSD 193
                     |..:..|.||.  :|...|    |..||                ..||.....:||
Human   595 ENVSSPQARTALLTGLTPGT--HYQLDVQLYHCTLLGPASPPAHVLLPPSGPPAPRHLHAQALSD 657

  Fly   194 ---RVNHK-PILMTGPLNLTLVVNSTGSMHCKYLSDL-----TSKKAWIFVPCHGMTNCSNNRSI 249
               ::..| |..:.||::             ||:.::     .....||.|.....|: :..|.:
Human   658 SEIQLTWKHPEALPGPIS-------------KYVVEVQVAGGAGDPLWIDVDRPEETS-TIIRGL 708

  Fly   250 IAEDKDQLDFVNVRMEQEG---WYTCVESNSLGQSNSTAYLRVVRSLHVLEAGV-------ASGS 304
            .|..:   ....:|...:|   |...||.::||  |.......|:.....|.|:       ..||
Human   709 NASTR---YLFRMRASIQGLGDWSNTVEESTLG--NGLQAEGPVQESRAAEEGLDQQLILAVVGS 768

  Fly   305 LHSTSFVYIFVFGGLIFIFMTTLFVFYAIRKMKHEKVLKQRIETVHQWTKKVIIFKPEGGGD--- 366
            :.:|...           .:..|.....||:    ..|.:|....:|          .|.|:   
Human   769 VSATCLT-----------ILAALLTLVCIRR----SCLHRRRTFTYQ----------SGSGEETI 808

  Fly   367 ---SSGSMDTMIMPVVRIQKQRTTVLQNGNEPAPFNEYEFPLDSNWELPRSHLVLGATLGEGAFG 428
               |||::.....|.:              :|.|.:   :|: ..||    .:.....:|||.||
Human   809 LQFSSGTLTLTRRPKL--------------QPEPLS---YPV-LEWE----DITFEDLIGEGNFG 851

  Fly   429 RVVMAEVN------NAIVAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQNGPLY 487
            :|:.|.:.      ||  |:||:||..:::|......|:||:..:|.|.|||||||.|...|.||
Human   852 QVIRAMIKKDGLKMNA--AIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLLGACKNRGYLY 914

  Fly   488 VIVEYAPHGNLKDFLYKNR------PFGRDQDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMDY 546
            :.:||||:|||.|||.|:|      .|.|:..          .|..::.:.|::||...|.||.|
Human   915 IAIEYAPYGNLLDFLRKSRVLETDPAFAREHG----------TASTLSSRQLLRFASDAANGMQY 969

  Fly   547 LASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYD 611
            |:.::.||||||||||||.::...|||||||:|   ..:.|.|.|.||||::|||.|||....|.
Human   970 LSEKQFIHRDLAARNVLVGENLASKIADFGLSR---GEEVYVKKTMGRLPVRWMAIESLNYSVYT 1031

  Fly   612 SKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNAD 676
            :||||||:|:|||||::.|..|| ..|:..|||..|..|.|||:|..|...:|.||||||.....
Human  1032 TKSDVWSFGVLLWEIVSLGGTPY-CGMTCAELYEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPY 1095

  Fly   677 DRPPFTEIVEYMDKLLQTKEDYLDVDI------ANLDTPPSTSDE 715
            :||||.:|...:.::|:.::.|:::.:      |.:|   :|::|
Human  1096 ERPPFAQIALQLGRMLEARKAYVNMSLFENFTYAGID---ATAEE 1137

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
htlNP_524394.2 Ig 101..191 CDD:472250 30/150 (20%)
Ig strand B 121..125 CDD:409353 1/3 (33%)
Ig strand C 134..138 CDD:409353 0/8 (0%)
Ig strand E 157..161 CDD:409353 2/21 (10%)
Ig strand F 171..176 CDD:409353 1/4 (25%)
Ig strand G 184..187 CDD:409353 2/2 (100%)
Ig 200..289 CDD:472250 18/96 (19%)
Ig strand B 216..220 CDD:409353 0/3 (0%)
Ig strand C 229..233 CDD:409353 0/3 (0%)
Ig strand E 255..259 CDD:409353 0/3 (0%)
Ig strand F 269..274 CDD:409353 1/4 (25%)
Ig strand G 282..285 CDD:409353 1/2 (50%)
Protein Kinases, catalytic domain 404..692 CDD:473864 129/299 (43%)
TIE1NP_005415.1 ig 129..210 CDD:395002
EGF_CA 227..256 CDD:238011
EGF_2 321..344 CDD:400365
Ig 350..441 CDD:472250 6/22 (27%)
Ig strand B 368..372 CDD:409556
Ig strand C 384..388 CDD:409556
Ig strand E 409..413 CDD:409556
Ig strand F 423..428 CDD:409556 1/3 (33%)
Ig strand G 436..439 CDD:409556 0/2 (0%)
fn3 452..536 CDD:394996 15/95 (16%)
fn3 548..632 CDD:394996 19/86 (22%)
FN3 644..736 CDD:238020 21/108 (19%)
PTKc_Tie1 836..1132 CDD:270671 131/315 (42%)
Blue background indicates that the domain is not in the aligned region.

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