DRSC/TRiP Functional Genomics Resources

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Protein Alignment htl and TEC

DIOPT Version :10

Sequence 1:NP_524394.2 Gene:htl / 42160 FlyBaseID:FBgn0010389 Length:729 Species:Drosophila melanogaster
Sequence 2:XP_047272062.1 Gene:TEC / 7006 HGNCID:11719 Length:722 Species:Homo sapiens


Alignment Length:486 Identity:131/486 - (26%)
Similarity:211/486 - (43%) Gaps:103/486 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   226 LTSKKA-------WIFVPCHGMTNCSNNRSIIAEDKDQLDFVNVRMEQEGWYTCVESNSLGQSNS 283
            :|.||:       |.   |..|......:.:.:|||:. .|:.....|.|.||.......|...|
Human   325 VTGKKSNNLDQYEWY---CRNMNRSKAEQLLRSEDKEG-GFMVRDSSQPGLYTVSLYTKFGGEGS 385

  Fly   284 TAYLRVVRSLHVLEAGVASGSLHSTSFVYI---FVFGGLIFIFMTTLFVFYAIRKMKHEKVLKQR 345
            :.:    |..|:.|      :..|....|:   ..||.:..|          |...||       
Human   386 SGF----RHYHIKE------TTTSPKKYYLAEKHAFGSIPEI----------IEYHKH------- 423

  Fly   346 IETVHQWTKKVIIFKPEGGGDSSGSMDTMIMPV-VRIQKQRTTVLQNGNEPAPFNEYEFPLDSNW 409
                                :::|.:..:..|| |:.:...||        |.|: ||     .|
Human   424 --------------------NAAGLVTRLRYPVSVKGKNAPTT--------AGFS-YE-----KW 454

  Fly   410 ELPRSHLVLGATLGEGAFGRVVMAEVNNAI-VAVKMVKEGHTDDDIASLVREMEVMKIIGRHINI 473
            |:..|.|.....||.|.||.|.:.:..... ||:|.::||...::  ..:.|.:||..: .|..:
Human   455 EINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEE--DFIEEAKVMMKL-THPKL 516

  Fly   474 INLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNR-PFGRDQDRDSSQPPPSPPAHVITEKDLIKFA 537
            :.|.|.|:|..|:|::.|:...|.|.:||.:.: .|.||.                    |:...
Human   517 VQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDV--------------------LLSMC 561

  Fly   538 HQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAP 602
            ..:..||:||.....|||||||||.|||:..|:|::|||:||.:.. |.|..::..:.|:||..|
Human   562 QDVCEGMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLD-DQYTSSSGAKFPVKWCPP 625

  Fly   603 ESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILM 667
            |......:.|||||||:|:|:||:.|.|:.|:....: .|:.|.:..|.|:.:|...|..:|.:|
Human   626 EVFNYSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTN-YEVVTMVTRGHRLYQPKLASNYVYEVM 689

  Fly   668 RQCWHFNADDRPPFTEIVEYMDKLLQTKEDY 698
            .:||....:.||.|.:::..:|:|::.:|.:
Human   690 LRCWQEKPEGRPSFEDLLRTIDELVECEETF 720

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
htlNP_524394.2 Ig 101..191 CDD:472250
Ig strand B 121..125 CDD:409353
Ig strand C 134..138 CDD:409353
Ig strand E 157..161 CDD:409353
Ig strand F 171..176 CDD:409353
Ig strand G 184..187 CDD:409353
Ig 200..289 CDD:472250 16/69 (23%)
Ig strand B 216..220 CDD:409353
Ig strand C 229..233 CDD:409353 2/10 (20%)
Ig strand E 255..259 CDD:409353 0/3 (0%)
Ig strand F 269..274 CDD:409353 2/4 (50%)
Ig strand G 282..285 CDD:409353 1/2 (50%)
Protein Kinases, catalytic domain 404..692 CDD:473864 92/289 (32%)
TECXP_047272062.1 PH_Btk 98..239 CDD:269944
SH3_Tec 273..328 CDD:212838 1/2 (50%)
SH2_Tec_Itk 331..437 CDD:198259 26/156 (17%)
PTKc_Tec_Rlk 456..715 CDD:270685 91/283 (32%)
Blue background indicates that the domain is not in the aligned region.

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