Protein Alignment htl and BTK

DIOPT Version :10

• Sequence 1: NP_524394.2
• Gene: htl / 42160
• FlyBaseID: FBgn0010389
• Length: 729
• Species: Drosophila melanogaster
• Sequence 2: NP_001274273.1
• Gene: BTK / 695
• HGNCID: 1133
• Length: 693
• Species: Homo sapiens
• Alignment Length: 684
• Identity: 152/684 - (22%)
• Similarity: 262/684 - (38%)
• Gaps: 184/684 - (26%)

  Fly    27 LLSIWQPAVQVEGRRQMANSQEMIKDHLGAR-SQNKTPAITNNANQSSTSSADLDDGAADDDDNK 90
            |:..:.|...::|  |.....:..|:.:|.: .:|:..::...::...|.. .|.....:|...|
Human   172 LVQKYHPCFWIDG--QYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKK-PLPPTPEEDQILK 233

  Fly    91 ADLPVNVSSKP------------YWRNPKKMSFLQTRPSGSLLTLNCHALGNPEPNITWYRNGTV 143
            ..||...::.|            |...|...:.||.|.......|.       |.|:.|:|....
Human   234 KPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILE-------ESNLPWWRARDK 291

  Fly   144 DWTRGYGSLKRNRWTLTMEDLVPGDCGNYTCKVCNSLGCIRHDTQVIVSDRVNHKPILMTGPLNL 208
            :...||               :|   .||..:..:|:
Human   292 NGQEGY---------------IP---SNYVTEAEDSI---------------------------- 310

  Fly   209 TLVVNSTGSMHCKYLSDLTSKKAWIFVPCHGMTNCSNNRSIIAEDKDQLDFVNVRME-QEGWYTC 272
                    .|:..|...:|..:|                       :||    ::.| :||.:..
Human   311 --------EMYEWYSKHMTRSQA-----------------------EQL----LKQEGKEGGFIV 340

  Fly   273 VESNSLGQSNSTAYLRVVRSLHVLEAGVASGSLHSTSFVYIFVFGGLIFIFMTTLFVFYAIRKMK 337
            .:|:..|:...:.:.:        ..|...|.:..    |:        :..|....:|...|..
Human   341 RDSSKAGKYTVSVFAK--------STGDPQGVIRH----YV--------VCSTPQSQYYLAEKHL 385

  Fly   338 HEKVLKQRIETVHQWTKKVIIFKPEGGGDSSGSMDTMIMPVVRIQKQRTTVLQNGNEPAPFN-EY 401
            ...:  ..:...||             .:|:|.:..:..||.:         ||.|.|:... .|
Human   386 FSTI--PELINYHQ-------------HNSAGLISRLKYPVSQ---------QNKNAPSTAGLGY 426

  Fly   402 EFPLDSNWELPRSHLVLGATLGEGAFGRVVMAEVNNAI-VAVKMVKEGHTDDDIASLVREMEVMK 465
                 .:||:....|.....||.|.||.|...:..... ||:||:|||...:|  ..:.|.:||.
Human   427 -----GSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSED--EFIEEAKVMM 484

  Fly   466 IIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPSPPAHVITE 530
            .:. |..::.|.|.|::..|:::|.||..:|.|.::|.:.|                   |....
Human   485 NLS-HEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMR-------------------HRFQT 529

  Fly   531 KDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRL 595
            :.|::....:...|:||.|::.:||||||||.||:|..|:|::||||:|.:.. |.|..:...:.
Human   530 QQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLD-DEYTSSVGSKF 593

  Fly   596 PIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCS 660
            |::|..||.|....:.||||:|::|:|:|||.:.|:.||....::|.. .::..|.|:.:|...|
Human   594 PVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETA-EHIAQGLRLYRPHLAS 657

  Fly   661 MNIYILMRQCWHFNADDRPPF----TEIVEYMDK 690
            ..:|.:|..|||..||:||.|    :.|::.||:
Human   658 EKVYTIMYSCWHEKADERPTFKILLSNILDVMDE 691

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	101..191	CDD:472250	17/101 (17%)
		Ig strand B	121..125	CDD:409353	1/3 (33%)
		Ig strand C	134..138	CDD:409353	1/3 (33%)
		Ig strand E	157..161	CDD:409353	0/3 (0%)
		Ig strand F	171..176	CDD:409353	2/4 (50%)
		Ig strand G	184..187	CDD:409353	0/2 (0%)
		Ig	200..289	CDD:472250	11/89 (12%)
		Ig strand B	216..220	CDD:409353	1/3 (33%)
		Ig strand C	229..233	CDD:409353	1/3 (33%)
		Ig strand E	255..259	CDD:409353	2/3 (67%)
		Ig strand F	269..274	CDD:409353	0/4 (0%)
		Ig strand G	282..285	CDD:409353	0/2 (0%)
		Protein Kinases, catalytic domain	404..692	CDD:473864	94/292 (32%)
BTK	NP_001274273.1	PH_Btk	40..200	CDD:269944	6/29 (21%)
		SH3_BTK	251..305	CDD:212839	15/78 (19%)
		SH2_Tec_Btk	308..413	CDD:198260	24/202 (12%)
		PTKc_Btk_Bmx	431..686	CDD:173657	89/278 (32%)