DRSC/TRiP Functional Genomics Resources

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Protein Alignment htl and MAP3K7

DIOPT Version :10

Sequence 1:NP_524394.2 Gene:htl / 42160 FlyBaseID:FBgn0010389 Length:729 Species:Drosophila melanogaster
Sequence 2:NP_663304.1 Gene:MAP3K7 / 6885 HGNCID:6859 Length:606 Species:Homo sapiens


Alignment Length:349 Identity:101/349 - (28%)
Similarity:158/349 - (45%) Gaps:79/349 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   410 ELPRSHLVLGATLGEGAFGRVVMAEVNNAIVAVKMVKEGHTDDDIASLVREMEVMKIIGRHINII 474
            |:....:.:...:|.||||.|..|:.....||:|.::   ::.:..:.:.|:..:..: .|.||:
Human    30 EIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIE---SESERKAFIVELRQLSRV-NHPNIV 90

  Fly   475 NLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPSPPAHVITEKDLIKFAHQ 539
            .|.|.|.  .|:.:::|||..|:|.:.|:...|.           |....||.::      :..|
Human    91 KLYGACL--NPVCLVMEYAEGGSLYNVLHGAEPL-----------PYYTAAHAMS------WCLQ 136

  Fly   540 IARGMDYLAS---RRCIHRDLAARN-VLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWM 600
            .::|:.||.|   :..|||||...| :||:...||||.|||.|.|||:     ..||.:....||
Human   137 CSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQT-----HMTNNKGSAAWM 196

  Fly   601 APESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMS-AEELYTYLMSGQR------MEKPAK 658
            |||..:...|..|.||:|:||:|||::| .::|:..|.. |..:...:.:|.|      :.||  
Human   197 APEVFEGSNYSEKCDVFSWGIILWEVIT-RRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKP-- 258

  Fly   659 CSMNIYILMRQCWHFNADDRPPFTEIVEYM----------DKLLQTKEDYLD------------- 700
                |..||.:||..:...||...|||:.|          |:.||....|.|             
Human   259 ----IESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQYPCQYSDEGQSNSATSTGSF 319

  Fly   701 VDIA----------NLDTPPSTSD 714
            :|||          |::..|:|:|
Human   320 MDIASTNTSNKSDTNMEQVPATND 343

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
htlNP_524394.2 Ig 101..191 CDD:472250
Ig strand B 121..125 CDD:409353
Ig strand C 134..138 CDD:409353
Ig strand E 157..161 CDD:409353
Ig strand F 171..176 CDD:409353
Ig strand G 184..187 CDD:409353
Ig 200..289 CDD:472250
Ig strand B 216..220 CDD:409353
Ig strand C 229..233 CDD:409353
Ig strand E 255..259 CDD:409353
Ig strand F 269..274 CDD:409353
Ig strand G 282..285 CDD:409353
Protein Kinases, catalytic domain 404..692 CDD:473864 90/302 (30%)
MAP3K7NP_663304.1 Interaction with MAPK8IP1. /evidence=ECO:0000250 1..300 91/304 (30%)
STKc_TAK1 42..292 CDD:270960 88/284 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 301..338 6/36 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 354..391
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 443..493
Blue background indicates that the domain is not in the aligned region.

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