Protein Alignment htl and SYK

DIOPT Version :10

• Sequence 1: NP_524394.2
• Gene: htl / 42160
• FlyBaseID: FBgn0010389
• Length: 729
• Species: Drosophila melanogaster
• Sequence 2: NP_003168.2
• Gene: SYK / 6850
• HGNCID: 11491
• Length: 635
• Species: Homo sapiens
• Alignment Length: 351
• Identity: 116/351 - (33%)
• Similarity: 175/351 - (49%)
• Gaps: 62/351 - (17%)

  Fly   383 KQRTTVLQNGNEP--APF------NEYEFPLDSN-WELP---------------RSHLVL-GATL 422
            :|.:||..|..||  ||:      .....|:|:. :|.|               |..|.| ...|
Human   313 RQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKEL 377

  Fly   423 GEGAFGRV-----VMAEVNNAIVAVKMVKEGHTDDDIA-SLVREMEVMKIIGRHINIINLLGCCS 481
            |.|.||.|     .|.:|... ||||::|....|..:. .|:.|..||:.:.... |:.::|.|.
Human   378 GSGNFGTVKKGYYQMKKVVKT-VAVKILKNEANDPALKDELLAEANVMQQLDNPY-IVRMIGICE 440

  Fly   482 QNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMDY 546
            ....: :::|.|..|.|..:|.:||                   || .:|::|:..||::.||.|
Human   441 AESWM-LVMEMAELGPLNKYLQQNR-------------------HV-KDKNIIELVHQVSMGMKY 484

  Fly   547 LASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTD-YYRKNTNGRLPIKWMAPESLQEKFY 610
            |.....:||||||||||:...:..||:||||::.:::.: ||:..|:|:.|:||.|||.:....:
Human   485 LEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKF 549

  Fly   611 DSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNA 675
            .|||||||:|:|:||..:|||:||.. |...|:...|..|:||..||.|...:|.||..||.::.
Human   550 SSKSDVWSFGVLMWEAFSYGQKPYRG-MKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDV 613

  Fly   676 DDRPPFTEIVEYMDKLLQTKEDYLDV 701
            ::||.|..:.      |:.:..|.||
Human   614 ENRPGFAAVE------LRLRNYYYDV 633

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	101..191	CDD:472250
		Ig strand B	121..125	CDD:409353
		Ig strand C	134..138	CDD:409353
		Ig strand E	157..161	CDD:409353
		Ig strand F	171..176	CDD:409353
		Ig strand G	184..187	CDD:409353
		Ig	200..289	CDD:472250
		Ig strand B	216..220	CDD:409353
		Ig strand C	229..233	CDD:409353
		Ig strand E	255..259	CDD:409353
		Ig strand F	269..274	CDD:409353
		Ig strand G	282..285	CDD:409353
		Protein Kinases, catalytic domain	404..692	CDD:473864	104/311 (33%)
SYK	NP_003168.2	SH2_N-SH2_Zap70_Syk_like	13..116	CDD:198191
		Interdomain A	108..167
		SH2_C-SH2_Syk_like	164..262	CDD:198264
		Interdomain B	260..370		13/56 (23%)
		PTKc_Syk	375..631	CDD:133247	98/285 (34%)