Protein Alignment htl and SRC

DIOPT Version :10

• Sequence 1: NP_524394.2
• Gene: htl / 42160
• FlyBaseID: FBgn0010389
• Length: 729
• Species: Drosophila melanogaster
• Sequence 2: XP_047296363.1
• Gene: SRC / 6714
• HGNCID: 11283
• Length: 562
• Species: Homo sapiens
• Alignment Length: 197
• Identity: 41/197 - (20%)
• Similarity: 73/197 - (37%)
• Gaps: 49/197 - (24%)

  Fly   132 VCGFLSDRL-----GRK--------PVYLGCLLMITIGHILLTFSMYLSWMTINATLAAMGFFCG 183
            |||.|...:     |:|        .||:|...:.|:.|::        |...:.:.|.......
Human  1037 VCGSLRPPIVIHSSGKKYGFSLRAIRVYMGDSDVYTVHHVV--------WSVEDGSPAQEAGLRA 1093

  Fly   184 GYMVTNF-------VILTEAFELPKSRLLVVSLNGWSVSMAVTALAASYTLNWYAYHTIFAIVGA 241
            |.::|:.       ::..:..||       :..:|..:|:..|||.          :|...:..|
Human  1094 GDLITHINGESVLGLVHMDVVEL-------LLKSGNKISLRTTALE----------NTSIKVGPA 1141

  Fly   242 --CIAIISLATCSESCRWLSANGLQNDA-KKIALQITLLNNNRDIEEDDISILSWHEILGFSAPT 303
              .:|...:|..|:..|.......:... |||:.|.::|:.:|.........||..|.|. .:||
Human  1142 RKNVAKGRMARRSKRSRRRETQDRRKSLFKKISKQTSVLHTSRSFSSGLHHSLSSSESLP-GSPT 1205

  Fly   304 HT 305
            |:
Human  1206 HS 1207

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	101..191	CDD:472250	15/78 (19%)
		Ig strand B	121..125	CDD:409353
		Ig strand C	134..138	CDD:409353	2/3 (67%)
		Ig strand E	157..161	CDD:409353	1/3 (33%)
		Ig strand F	171..176	CDD:409353	0/4 (0%)
		Ig strand G	184..187	CDD:409353	1/2 (50%)
		Ig	200..289	CDD:472250	17/91 (19%)
		Ig strand B	216..220	CDD:409353	0/3 (0%)
		Ig strand C	229..233	CDD:409353	0/3 (0%)
		Ig strand E	255..259	CDD:409353	1/3 (33%)
		Ig strand F	269..274	CDD:409353	2/4 (50%)
		Ig strand G	282..285	CDD:409353	0/2 (0%)
		Protein Kinases, catalytic domain	404..692	CDD:473864
SRC	XP_047296363.1	SH3_Src	114..169	CDD:212941
		SH2_Src_Src	173..273	CDD:198228
		PTKc_Src	286..562	CDD:270656