DRSC/TRiP Functional Genomics Resources

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Protein Alignment htl and BMX

DIOPT Version :10

Sequence 1:NP_524394.2 Gene:htl / 42160 FlyBaseID:FBgn0010389 Length:729 Species:Drosophila melanogaster
Sequence 2:NP_001712.1 Gene:BMX / 660 HGNCID:1079 Length:675 Species:Homo sapiens


Alignment Length:656 Identity:161/656 - (24%)
Similarity:255/656 - (38%) Gaps:191/656 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    63 PAITNNANQSSTSSADLDDGAADDDDNKADLPVNVSSKPYWRNPKKMSFLQTRPSGSL----LTL 123
            |.:..:|..|||:.|..|               |.|.|.|...|         ||.|.    ...
Human   178 PVLKMDAPSSSTTLAQYD---------------NESKKNYGSQP---------PSSSTSLAQYDS 218

  Fly   124 NCHALGNPEPNITWY---RNGTVDWTRGYGSLKRNRWTLTMEDLVPGDCGNYTCKVCNSLGCIRH 185
            |...:...:||....   |....||.:    :::.:.:.:.||:...:                 
Human   219 NSKKIYGSQPNFNMQYIPREDFPDWWQ----VRKLKSSSSSEDVASSN----------------- 262

  Fly   186 DTQVIVSDR-VNHKPILMTGPLNLTLVVNSTGSMHCKYLSDLTSKKAWIFVPCHGMTNCSNNRSI 249
                 ..:| |||                            .|||.:|.|           ..|.
Human   263 -----QKERNVNH----------------------------TTSKISWEF-----------PESS 283

  Fly   250 IAEDKDQLDFVNVRMEQEGWYTCVESNSLGQSNSTAYLR--------VVRSLHVLEAGVASGSLH 306
            .:|:::.||       ...|:    :.::.:|.|...||        :||:..  :.|:.:.||.
Human   284 SSEEEENLD-------DYDWF----AGNISRSQSEQLLRQKGKEGAFMVRNSS--QVGMYTVSLF 335

  Fly   307 S--------TSFVYIFVFGGLIFIFMTTLFVFYAIRKMKHEKVLKQRIETVHQWTKKVIIFKPEG 363
            |        |...|.........:::...:.|.:|.|:.|          .||            
Human   336 SKAVNDKKGTVKHYHVHTNAENKLYLAENYCFDSIPKLIH----------YHQ------------ 378

  Fly   364 GGDSSGSMDTMIMPV-VRIQKQRTTV-LQNGNEPAPFNEYEFPLDSNWELPRSHLVLGATLGEGA 426
             .:|:|.:..:..|| .:..|...:| |.||               .|||.|..:.|...||.|.
Human   379 -HNSAGMITRLRHPVSTKANKVPDSVSLGNG---------------IWELKREEITLLKELGSGQ 427

  Fly   427 FGRVVMAEVNNAI-VAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQNGPLYVIV 490
            ||.|.:.:..... |||||:|||...:|  ...:|.:.|..:. |..::...|.||:..|:|::.
Human   428 FGVVQLGKWKGQYDVAVKMIKEGSMSED--EFFQEAQTMMKLS-HPKLVKFYGVCSKEYPIYIVT 489

  Fly   491 EYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHR 555
            ||..:|.|.::|   |..|:..:       ||         .|::..:.:..||.:|.|.:.|||
Human   490 EYISNGCLLNYL---RSHGKGLE-------PS---------QLLEMCYDVCEGMAFLESHQFIHR 535

  Fly   556 DLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYG 620
            ||||||.||..|..:|::|||:.|.:.. |.|..:...:.|:||.|||......|.||||||::|
Human   536 DLAARNCLVDRDLCVKVSDFGMTRYVLD-DQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFG 599

  Fly   621 ILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIV 685
            ||:||:.:.|:||| .:....::...:..|.|:.:|...|..||.:|..|||...:.||.|.:::
Human   600 ILMWEVFSLGKQPY-DLYDNSQVVLKVSQGHRLYRPHLASDTIYQIMYSCWHELPEKRPTFQQLL 663

  Fly   686 EYMDKL 691
            ..::.|
Human   664 SSIEPL 669

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
htlNP_524394.2 Ig 101..191 CDD:472250 13/96 (14%)
Ig strand B 121..125 CDD:409353 0/3 (0%)
Ig strand C 134..138 CDD:409353 1/3 (33%)
Ig strand E 157..161 CDD:409353 0/3 (0%)
Ig strand F 171..176 CDD:409353 0/4 (0%)
Ig strand G 184..187 CDD:409353 0/2 (0%)
Ig 200..289 CDD:472250 14/96 (15%)
Ig strand B 216..220 CDD:409353 0/3 (0%)
Ig strand C 229..233 CDD:409353 1/3 (33%)
Ig strand E 255..259 CDD:409353 1/3 (33%)
Ig strand F 269..274 CDD:409353 1/4 (25%)
Ig strand G 282..285 CDD:409353 1/2 (50%)
Protein Kinases, catalytic domain 404..692 CDD:473864 97/289 (34%)
BMXNP_001712.1 PH_Btk 7..147 CDD:269944
SH2_Tec_Bmx 289..394 CDD:198262 25/140 (18%)
PTKc_Btk_Bmx 412..667 CDD:173657 94/278 (34%)
CAV1-binding 596..603 4/6 (67%)
Blue background indicates that the domain is not in the aligned region.

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