DRSC/TRiP Functional Genomics Resources

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Protein Alignment htl and ntrk2a

DIOPT Version :10

Sequence 1:NP_524394.2 Gene:htl / 42160 FlyBaseID:FBgn0010389 Length:729 Species:Drosophila melanogaster
Sequence 2:NP_001353483.1 Gene:ntrk2a / 65090 ZFINID:ZDB-GENE-010126-1 Length:791 Species:Danio rerio


Alignment Length:658 Identity:182/658 - (27%)
Similarity:286/658 - (43%) Gaps:110/658 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    94 PVNVSSKPYWRNPKKMSFLQTRPSGSLLTLNCHALGNPEPNITW--YRNGTVDWTRGYGSLKRNR 156
            |.||:.|                .|..:||.|:..|.|.||:||  .:..:.....|.|.:.|::
Zfish   192 PTNVTMK----------------KGLNVTLTCNTSGMPTPNLTWTTCKLNSAFKEEGSGQISRSQ 240

  Fly   157 WTLTMEDLVPGDCGNYTCKVCNSLGCIRHDTQVIVSDRVNHKPIL--MTGPLN-----LTLVVNS 214
            ..||....:...| ..||:..|.:|    :::..|...:...|::  :|..:.     :...|:.
Zfish   241 LKLTNVSSLDNKC-RITCRSDNMVG----ESEASVELDILFPPVISKLTDAIPDHHWCIPFSVSG 300

  Fly   215 TGSMHCKYLSDLTSKKAWIFVPCHGMTN---------CSNNRSIIAEDKDQLD---FVNVRMEQE 267
            ......::|.|....:...|:  |.|.:         |.           |||   .:|     .
Zfish   301 NPKPKLRWLLDEQPIQEGKFI--HTMIHDYSEGEYHGCL-----------QLDSPTHIN-----N 347

  Fly   268 GWYTCVESNSLGQSNSTAYLRVVRSLHVL-EAGVASGSLHSTSF------------VYIFVFGGL 319
            |.||.:..|..|:.:...      |.|.: |....|..|:..:.            |.::|..|:
Zfish   348 GMYTLLARNQFGEDSKAV------SAHFMHEPWNVSEPLYYDATTDDTPLGPPEDKVAVYVVVGI 406

  Fly   320 IFIFMTTLFVFYAIRKM-KHEKV-LKQRIETVHQWTKKVIIFKPEGGGDSSGSMDTMIMPVVRIQ 382
            ..|..|...:...|.|. ::.|. :|.....:...............|.::.|...|....|.|.
Zfish   407 AAITFTGFVLMLVILKFGRNSKFGIKGPSSVISNDDDSASPLHHVSNGSNTPSSSDMNADAVIIG 471

  Fly   383 KQRTTVLQNGNEPAPFNEYEFPLDSN---WELPRSHLVLGATLGEGAFGRVVMAEVNN------- 437
            ..:..|::|   |..|......|.|:   ..:.|.::||...|||||||:|.:||..|       
Zfish   472 MTKIPVIEN---PQYFRSTSSLLKSDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLSADQEK 533

  Fly   438 AIVAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFL 502
            .:||||.:||. :::......||.|::..: :|.:|:...|.|.::.||.::.||..||:|..||
Zfish   534 ILVAVKTLKEA-SENARKDFHREAELLTNL-QHEHIVTFYGVCVESDPLIMVFEYMMHGDLNKFL 596

  Fly   503 YKNRPFGRD----QDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVL 563
               |..|.|    .|....|...      :|:..::..|.|||.||.||||:..:|||||.||.|
Zfish   597 ---RAHGPDAVLMSDGQIQQQAE------LTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCL 652

  Fly   564 VSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMT 628
            |.::.::||.|||::||:.||||||...:..|||:||.|||:..:.:.::|||||.|::||||.|
Zfish   653 VGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFT 717

  Fly   629 YGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKLLQ 693
            ||:||:.. :|..|:...:..|:.:::|..|...:|.||..||......|....||...:..|.:
Zfish   718 YGKQPWYQ-LSNNEVIECITQGRVLQRPRTCPKEVYDLMLGCWQREPHTRLNIKEIHNLLLNLAK 781

  Fly   694 TKEDYLDV 701
            ....|||:
Zfish   782 ASPVYLDI 789

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
htlNP_524394.2 Ig 101..191 CDD:472250 20/91 (22%)
Ig strand B 121..125 CDD:409353 2/3 (67%)
Ig strand C 134..138 CDD:409353 3/5 (60%)
Ig strand E 157..161 CDD:409353 1/3 (33%)
Ig strand F 171..176 CDD:409353 2/4 (50%)
Ig strand G 184..187 CDD:409353 0/2 (0%)
Ig 200..289 CDD:472250 17/107 (16%)
Ig strand B 216..220 CDD:409353 0/3 (0%)
Ig strand C 229..233 CDD:409353 0/3 (0%)
Ig strand E 255..259 CDD:409353 3/6 (50%)
Ig strand F 269..274 CDD:409353 2/4 (50%)
Ig strand G 282..285 CDD:409353 0/2 (0%)
Protein Kinases, catalytic domain 404..692 CDD:473864 112/301 (37%)
ntrk2aNP_001353483.1 LRR_8 84..143 CDD:404697
leucine-rich repeat 86..109 CDD:275378
leucine-rich repeat 110..132 CDD:275378
Ig 186..272 CDD:472250 25/100 (25%)
Ig strand B 203..207 CDD:409353 2/3 (67%)
Ig strand C 216..220 CDD:409353 2/3 (67%)
Ig strand E 239..243 CDD:409353 0/3 (0%)
Ig strand F 254..259 CDD:409353 2/4 (50%)
Ig strand G 267..270 CDD:409353 0/2 (0%)
Ig 277..370 CDD:472250 20/116 (17%)
Ig strand B 292..296 CDD:409353 0/3 (0%)
Ig strand C 305..309 CDD:409353 0/3 (0%)
Ig strand E 335..339 CDD:409353 1/14 (7%)
Ig strand F 349..354 CDD:409353 2/4 (50%)
Ig strand G 362..365 CDD:409353 0/2 (0%)
Protein Kinases, catalytic domain 499..788 CDD:473864 112/300 (37%)
Blue background indicates that the domain is not in the aligned region.

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