DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment htl and Kit

DIOPT Version :9

Sequence 1:	NP_524394.2	Gene:	htl / 42160	FlyBaseID:	FBgn0010389	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_071600.1	Gene:	Kit / 64030	RGDID:	620568	Length:	978	Species:	Rattus norvegicus

Alignment Length:	738	Identity:	195/738 - (26%)
Similarity:	308/738 - (41%)	Gaps:	197/738 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   130 NPEPNITWYRNGTVDWTRGYGSLKRNRW-----------TLTMEDLVPGDCGNYTCKVCNSLGCI 183
            ||:|             :....:|||.|           |||:......|.|.:.|...|:.|..
  Rat   250 NPQP-------------QSKAQVKRNSWHQGDFNYERQETLTISSARVNDSGVFMCYANNTFGSA 301

  Fly   184 RHDTQVIVSDR-------VNHKPILMTGPLNLTLVVNSTGSMHCKYLSDLTSKKAWIFVPCHGMT 241
            ...|.:.|.::       |.:..:.:|...|:.|||........::       :.||:     |.
  Rat   302 NVTTTLKVVEKGFINIFPVKNTTVFVTDGENVDLVVEFEAYPKPEH-------QQWIY-----MN 354

  Fly   242 NCSNNRS---IIAEDKDQLDFVN------VRMEQEGWYTCVESNSLGQSNST------------A 285
            ....||.   :.::::..:.:||      ::..:.|.||.:.|||...::.|            .
  Rat   355 RTPTNRGEDYVKSDNQSNIRYVNELRLTRLKGTEGGTYTFLVSNSDVSASVTFDVYVNTKPEILT 419

  Fly   286 YLRVVRS-LHVLEAG----------------------------------------VASGSLHSTS 309
            |.|::.. |..:.||                                        |...|:.|:
  Rat   420 YDRLMNGRLQCVAAGFPEPTIDWYFCTGAEQRCTVPVPPVDVQIQNASVSPFGKLVVQSSIDSS- 483

  Fly   310 FVYIFVFGGLI------FIFMTTLFVFYAIRKMKHEKVLKQRIETVHQWTKKVIIFKPEGGGDSS 368
               :|...|.:      .:..::.|..:|.:...     |::|:....:|..:|.|..     ::
  Rat   484 ---VFRHNGTVECKASNAVGKSSAFFNFAFKGNS-----KEQIQPHTLFTPLLIGFVV-----TA 535

  Fly   369 GSMDTMIM---------PVVRIQKQRTTVLQNGNEPAPFNEYEFPLDSNWELPRSHLVLGATLGE 424
            |.|..::|         |:..:|.:....: |||.....:..:.|.|..||.||:.|..|.|||.
  Rat   536 GLMGIIVMVLAYKYLQKPMYEVQWKVVEEI-NGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGA 599

  Fly   425 GAFGRVVMAEVNNAI-------VAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQ 482
            ||||:||.|.....|       |||||:|......:..:|:.|::|:..:|.|:||:||||.|:.
  Rat   600 GAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTV 664

  Fly   483 NGPLYVIVEYAPHGNLKDF--------------------LYKNRPFGRDQDRDSS------QPPP 521
            .||..||.||..:|:|.:|                    ||||....::...|||      :|..
  Rat   665 GGPTLVITEYCCYGDLLNFLRRKRDSFIFSKQEEQADAALYKNLLHSKESSCDSSNEYMDMKPGV 729

  Fly   522 SPPAHVITEK-----------------------------DLIKFAHQIARGMDYLASRRCIHRDL 557
            |......|:|                             ||:.|::|:|:||.:|||:.||||||
  Rat   730 SYVVPTKTDKRRSARIDSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDL 794

  Fly   558 AARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGIL 622
            ||||:|::...:.||.||||||||::...|....|.|||:|||||||:....|..:||||||||.
  Rat   795 AARNILLTHGRITKICDFGLARDIRNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIF 859

  Fly   623 LWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEY 687
            |||:.:.|..|||.:....:.|..:..|.||..|......:|.:|:.||..:...||.|.::|:.
  Rat   860 LWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAAMYEVMKTCWDADPLKRPTFKQVVQL 924

  Fly   688 MDKLLQTKEDYLDVDIANLDTPP 710
            ::|.:.....::..::||.:..|
  Rat   925 IEKQISDSSKHIYSNLANCNPNP 947

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	112..191	CDD:299845	16/71 (23%)
		IG_like	113..191	CDD:214653	16/71 (23%)
		IG_like	205..289	CDD:214653	19/104 (18%)
		PKc_like	404..692	CDD:304357	130/349 (37%)
		STYKc	416..688	CDD:214568	123/333 (37%)
Kit	NP_071600.1	ig	216..307	CDD:278476	16/69 (23%)
		IG_like	220..309	CDD:214653	16/71 (23%)
		Ig4_SCFR	313..413	CDD:143268	20/111 (18%)
		Ig	428..503	CDD:299845	8/78 (10%)
		PKc_like	555..929	CDD:304357	134/374 (36%)
		Pkinase_Tyr	591..925	CDD:285015	123/333 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810