DRSC/TRiP Functional Genomics Resources

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Protein Alignment htl and BLK

DIOPT Version :10

Sequence 1:NP_524394.2 Gene:htl / 42160 FlyBaseID:FBgn0010389 Length:729 Species:Drosophila melanogaster
Sequence 2:XP_011542126.1 Gene:BLK / 640 HGNCID:1057 Length:531 Species:Homo sapiens


Alignment Length:478 Identity:142/478 - (29%)
Similarity:200/478 - (41%) Gaps:120/478 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   264 MEQEGWYTCVESNSLGQSNSTAYLRVVRSLHVLEAGVASGSLHSTSFVYIFVFGGLIFIFMTTLF 328
            :|.|.|:...:.....:....|.:....|..:.|:....|:. |.|...:...|.||        
Human   119 LEMERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAF-SLSVKDVTTQGELI-------- 174

  Fly   329 VFYAIRKMKHEKV---------LKQRI------ETVHQWTKKVIIFKPEGGGDSSGSMDTMIMPV 378
                    ||.|:         :..||      ..|..::||         ||  |....:.:|.
Human   175 --------KHYKIRCLDEGGYYISPRITFPSLQALVQHYSKK---------GD--GLCQRLTLPC 220

  Fly   379 VRIQKQRTTVLQNGNEPAPFNEYEFPLDSNWELPRSHLVLGATLGEGAFGRVVMAEV-NNAIVAV 442
            ||              |||.|.:   ....||:||..|.|...||.|.||.|.|... ||..||:
Human   221 VR--------------PAPQNPW---AQDEWEIPRQSLRLVRKLGSGQFGEVWMGYYKNNMKVAI 268

  Fly   443 KMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQNGPLYVIVEY-----APH------- 495
            |.:|||....:  :.:.|..|||.: :|..::.|....::. |:|::.||     ||.       
Human   269 KTLKEGTMSPE--AFLGEANVMKAL-QHERLVRLYAVVTKE-PIYIVTEYMARGGAPRRAASSER 329

  Fly   496 --------------GNLKDFLYKNRPFGRDQDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMDY 546
                          |.|.|||      ..|:....|.|            .||..:.|||.||.|
Human   330 GGRAGLSRRRRVRCGCLLDFL------KTDEGSRLSLP------------RLIDMSAQIAEGMAY 376

  Fly   547 LASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYD 611
            :.....|||||.|.|:|||:....|||||||||.|.|.  |......:.||||.|||::....:.
Human   377 IERMNSIHRDLRAANILVSEALCCKIADFGLARIIDSE--YTAQEGAKFPIKWTAPEAIHFGVFT 439

  Fly   612 SKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYI-LMRQCWHFNA 675
            .|:||||:|:||.|::|||:.|||. ||..|:...|..|.||.:|..|...:|. ::.:||....
Human   440 IKADVWSFGVLLMEVVTYGRVPYPG-MSNPEVIRNLERGYRMPRPDTCPPELYRGVIAECWRSRP 503

  Fly   676 DDRPPFTEIVEYMDKLLQTKEDY 698
            ::||.|    |::..:|   ||:
Human   504 EERPTF----EFLQSVL---EDF 519

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
htlNP_524394.2 Ig 101..191 CDD:472250
Ig strand B 121..125 CDD:409353
Ig strand C 134..138 CDD:409353
Ig strand E 157..161 CDD:409353
Ig strand F 171..176 CDD:409353
Ig strand G 184..187 CDD:409353
Ig 200..289 CDD:472250 4/24 (17%)
Ig strand B 216..220 CDD:409353
Ig strand C 229..233 CDD:409353
Ig strand E 255..259 CDD:409353
Ig strand F 269..274 CDD:409353 1/4 (25%)
Ig strand G 282..285 CDD:409353 0/2 (0%)
Protein Kinases, catalytic domain 404..692 CDD:473864 109/315 (35%)
BLKXP_011542126.1 SH3_Blk 62..115 CDD:212942
SH2_Src_Blk 120..219 CDD:198234 23/126 (18%)
Protein Kinases, catalytic domain 233..522 CDD:473864 112/319 (35%)
Blue background indicates that the domain is not in the aligned region.

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