Protein Alignment htl and ROS1

DIOPT Version :10

• Sequence 1: NP_524394.2
• Gene: htl / 42160
• FlyBaseID: FBgn0010389
• Length: 729
• Species: Drosophila melanogaster
• Sequence 2: XP_011534351.1
• Gene: ROS1 / 6098
• HGNCID: 10261
• Length: 2357
• Species: Homo sapiens
• Alignment Length: 725
• Identity: 202/725 - (27%)
• Similarity: 293/725 - (40%)
• Gaps: 180/725 - (24%)

  Fly    92 DLPVNVSSKPYWRNPKKMSFLQTRPSGS----LLTLNCHA---------------LGNPE----- 132
            :.|:..|..|..|    ::.|.||.||.    |..|.||:               ...||
Human  1615 ETPLRQSEFPNGR----LTLLVTRLSGGNIYVLKVLACHSEEMWCTESHPVTVEMFNTPEKPYSL 1675

  Fly   133 -PNIT-----WYRNGTVDWTRGYGSLKRNRWTLTMEDLVPGDCGN---YTCKVCNSLGCIRHDTQ 188
             |..|     |.....|:..|.:..|:  :|.......|...|..   |.|.:.|......::.:
Human  1676 VPENTSLQFNWKAPLNVNLIRFWVELQ--KWKYNEFYHVKTSCSQGPAYVCNITNLQPYTSYNVR 1738

  Fly   189 VIVSDRVNHKPILMTGPLNLTLVVNSTGSMHCKYLSDLTSKKAWIFVPCHGMTNCSNNRSIIAED 253
            |:|        :..||.       |||.      |.:....||       |:.|......::...
Human  1739 VVV--------VYKTGE-------NSTS------LPESFKTKA-------GVPNKPGIPKLLEGS 1775

  Fly   254 KDQLDFVNVRMEQEG---WYTCVE-----SNSLGQSN-----------------STAYLRVVRSL 293
            |:.:.:  .:.|..|   .|..:|     ||:|...|                 .:..|:.:...
Human  1776 KNSIQW--EKAEDNGCRITYYILEIRKSTSNNLQNQNLRWKMTFNGSCSSVCTWKSKNLKGIFQF 1838

  Fly   294 HVLEA-----GVASGS------------LHSTSFVYIFVFGGLIFIFMTTLFVFYAIRKMKHEKV 341
            .|:.|     |..||.            :..|||:...:.|  ||:.:|....|...|::|::|.
Human  1839 RVVAANNLGFGEYSGISENIILVGDDFWIPETSFILTIIVG--IFLVVTIPLTFVWHRRLKNQKS 1901

  Fly   342 LKQRIETVHQWTKKVIIFK--PEGGGDSSGSMDTMIMPVVRIQKQRTTVLQNGNEPAPFNEYEFP 404
            .|:.:..:....|::...:  ..|.|.::.......:|         |..:..|.||
Human  1902 AKEGVTVLINEDKELAELRGLAAGVGLANACYAIHTLP---------TQEEIENLPA-------- 1949

  Fly   405 LDSNWELPRSHLVLGATLGEGAFGRVVMAEVNNAI--------VAVKMVKEGHTDDDIASLVREM 461
                  .||..|.|...||.||||.|......:.:        ||||.:|:|.||.:....::|.
Human  1950 ------FPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEA 2008

  Fly   462 EVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRP---FGRDQDRDSSQPPPSP 523
            .:|... .|.||:..||.|..|.|.|:|:|....|:|..:|.|.|.   :|
Human  2009 HLMSKF-NHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYG-------------- 2058

  Fly   524 PAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVS-DDY----VLKIADFGLARDIQS 583
              .::|..||:.....|::|..||.....|||||||||.||| .||    ::||.||||||||..
Human  2059 --PLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYK 2121

  Fly   584 TDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLM 648
            .|||||...|.||::|||||||.:..:.::|||||:|||:|||:|.|.||||...:.:.| .|:.
Human  2122 NDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVL-NYVQ 2185

  Fly   649 SGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKLLQTKEDYLDV-----DIANLDT 708
            :|.|:|.|..|..:::.||.|||....|.||.|..|   .|:|...:..:|:.     |.||...
Human  2186 TGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRI---QDQLQLFRNFFLNSIYKSRDEANNSG 2247

  Fly   709 PPSTSDEEED 718
            ..:.|.|.||
Human  2248 VINESFEGED 2257

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	101..191	CDD:472250	26/122 (21%)
		Ig strand B	121..125	CDD:409353	1/3 (33%)
		Ig strand C	134..138	CDD:409353	1/8 (13%)
		Ig strand E	157..161	CDD:409353	1/3 (33%)
		Ig strand F	171..176	CDD:409353	2/7 (29%)
		Ig strand G	184..187	CDD:409353	0/2 (0%)
		Ig	200..289	CDD:472250	20/113 (18%)
		Ig strand B	216..220	CDD:409353	0/3 (0%)
		Ig strand C	229..233	CDD:409353	2/3 (67%)
		Ig strand E	255..259	CDD:409353	0/3 (0%)
		Ig strand F	269..274	CDD:409353	1/4 (25%)
		Ig strand G	282..285	CDD:409353	1/19 (5%)
		Protein Kinases, catalytic domain	404..692	CDD:473864	119/303 (39%)
ROS1	XP_011534351.1	FN3	<103..>297	CDD:442628
		FN3	211..290	CDD:238020
		FN3	567..677	CDD:238020
		FN3	1051..1157	CDD:238020
		FN3	1441..1867	CDD:442628	54/287 (19%)
		FN3	1669..1758	CDD:238020	22/111 (20%)
		FN3	1763..1852	CDD:238020	14/90 (16%)
		PTKc_c-ros	1960..2226	CDD:270640	115/286 (40%)