Protein Alignment htl and Erbb4

DIOPT Version :10

• Sequence 1: NP_524394.2
• Gene: htl / 42160
• FlyBaseID: FBgn0010389
• Length: 729
• Species: Drosophila melanogaster
• Sequence 2: NP_067719.2
• Gene: Erbb4 / 59323
• RGDID: 620486
• Length: 1308
• Species: Rattus norvegicus
• Alignment Length: 662
• Identity: 165/662 - (24%)
• Similarity: 266/662 - (40%)
• Gaps: 185/662 - (27%)

  Fly   134 NITWYRNGTVDWTRGYGSL--------KRNRWTLTMEDLVPGD-CGNYTC--------------- 174
            |:.:|.  |::||..:.::        .|.....|.|.:|... |.|..|
  Rat   465 NLCYYH--TINWTTLFSTVNQRIVIRDNRRAENCTAEGMVCNHLCSNDGCWGPGPDQCLSCRRFS 527

  Fly   175 --KVC---------------NSLGCIRHDTQVIVSDRVN------HKPILMTGPLNLTLVVNSTG 216
              |:|               |...|:..|:|   .:::.      |.|    ||.|.|...:...
  Rat   528 RGKICIESCNLYDGEFREFENGSICVECDSQ---CEKMEDGLLTCHGP----GPDNCTKCSHFKD 585

  Fly   217 SMHC--KYLSDLTSKKAWIFV---------PCHGMTNCSNNRSIIAEDKDQLDFVNVRMEQEGWY 270
            ..:|  |....|....::||.         |||  .||:..    .......|.:        :|
  Rat   586 GPNCVEKCPDGLQGANSFIFKYADQDRECHPCH--PNCTQG----CNGPTSHDCI--------YY 636

  Fly   271 TCVESNSLGQSNSTAYLRVVRSLHVLEAGVASGSLHSTSFVYIFVFGGL-IFIFMTTLFVFYAIR 334
            .....::|.|             |.....:|:|           |.||| |.:.|...|..|..|
  Rat   637 PWTGHSTLPQ-------------HARTPLIAAG-----------VIGGLFILVIMALTFAVYVRR 677

  Fly   335 K-MKHEKVLKQRIETVHQWTKKVIIFKPEGGGDSSGSMDTMIMPVVRIQKQRTTVLQNGNEPAPF 398
            | :|.::.|::.:||                        .::.|:.          .:|..|
  Rat   678 KSIKKKRALRRFLET------------------------ELVEPLT----------PSGTAP--- 705

  Fly   399 NEYEFPLDSNWELPRSHLVLGATLGEGAFGRVVM------AEVNNAIVAVKMVKEGHTDDDIASL 457
            |:.:..:....||.|..:     ||.||||.|..      .|.....||:|::.|..........
  Rat   706 NQAQLRILKETELKRVKV-----LGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEF 765

  Fly   458 VREMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPS 522
            :.|..:|..:. |.:::.|||.| .:..:.::.:..|||.|.:::::::      |...||.
  Rat   766 MDEALIMASVD-HPHLVRLLGVC-LSPTIQLVTQLMPHGCLLEYVHEHK------DNIGSQL--- 819

  Fly   523 PPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYY 587
                      |:.:..|||:||.||..||.:|||||||||||.....:||.||||||.::..:..
  Rat   820 ----------LLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKE 874

  Fly   588 RKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQR 652
            .....|::||||||.|.:..:.:..:|||||||:.:||:||:|.:||..| ...|:...|..|:|
  Rat   875 YNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGI-PTREIPDLLEKGER 938

  Fly   653 MEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKLLQTKEDYLDVDIANLDTPPSTSD--- 714
            :.:|..|::::|::|.:||..:||.||.|.|:.....::.:..:.||.:...:....||.:|
  Rat   939 LPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKF 1003

  Fly   715 -----EEEDETD 721
                 :|||..|
  Rat  1004 FQNLLDEEDLED 1015

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	101..191	CDD:472250	18/97 (19%)
		Ig strand B	121..125	CDD:409353
		Ig strand C	134..138	CDD:409353	1/3 (33%)
		Ig strand E	157..161	CDD:409353	0/3 (0%)
		Ig strand F	171..176	CDD:409353	2/21 (10%)
		Ig strand G	184..187	CDD:409353	0/2 (0%)
		Ig	200..289	CDD:472250	18/99 (18%)
		Ig strand B	216..220	CDD:409353	0/3 (0%)
		Ig strand C	229..233	CDD:409353	0/3 (0%)
		Ig strand E	255..259	CDD:409353	0/3 (0%)
		Ig strand F	269..274	CDD:409353	1/4 (25%)
		Ig strand G	282..285	CDD:409353	0/2 (0%)
		Protein Kinases, catalytic domain	404..692	CDD:473864	97/293 (33%)
Erbb4	NP_067719.2	Recep_L_domain	55..167	CDD:460032
		Furin-like	186..332	CDD:395614
		Recep_L_domain	358..478	CDD:460032	5/14 (36%)
		GF_recep_IV	502..634	CDD:464344	27/144 (19%)
		TM_ErbB4	642..685	CDD:213053	16/66 (24%)
		Nuclear localization signal. /evidence=ECO:0000250	676..684		3/7 (43%)
		PTKc_HER4	710..1012	CDD:173655	103/328 (31%)
		PPxy motif 1	1032..1035
		PPxY motif 2	1298..1301
		PDZ-binding	1306..1308