DRSC/TRiP Functional Genomics Resources

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Protein Alignment htl and Ntrk1

DIOPT Version :10

Sequence 1:NP_524394.2 Gene:htl / 42160 FlyBaseID:FBgn0010389 Length:729 Species:Drosophila melanogaster
Sequence 2:NP_067600.1 Gene:Ntrk1 / 59109 RGDID:620144 Length:799 Species:Rattus norvegicus


Alignment Length:759 Identity:196/759 - (25%)
Similarity:299/759 - (39%) Gaps:232/759 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 ITMTSGSLVV---LFLLLSIWQPAVQ--------VEGRRQMANSQEMIKDHLGARSQNKTPAITN 67
            |.|.:.|:.|   :||...:...|:|        :||...|..|.::  ..||....|    :|:
  Rat   200 IQMPNDSVEVGDDVFLQCQVEGQALQQADWILTELEGTATMKKSGDL--PSLGLTLVN----VTS 258

  Fly    68 NANQSSTSSADLDDGAADDDDNKADLPVNVS-------------SKPYWRNPKKMSFLQTRPSGS 119
            :.|:.:.:.      .|::|..:|::.|.||             .:.:|..|..:.         
  Rat   259 DLNKKNVTC------WAENDVGRAEVSVQVSVSFPASVHLGKAVEQHHWCIPFSVD--------- 308

  Fly   120 LLTLNCHALGNPEPNITWYRNGTV-----------------DWTRGYGSLKRNRWTLTMEDLVPG 167
                     |.|.|::.|:.||:|                 :.|..:|.|:.|:.|..       
  Rat   309 ---------GQPAPSLRWFFNGSVLNETSFIFTQFLESALTNETMRHGCLRLNQPTHV------- 357

  Fly   168 DCGNYTCKVCNSLGCIRHDTQVIVSDRV----NHKPILMTGPLNLTLV-VNSTGSMHCKYLSDLT 227
            :.||||....|..|...........|..    ...||    |::.:.| .|||            
  Rat   358 NNGNYTLLAANPYGQAAASIMAAFMDNPFEFNPEDPI----PVSFSPVDTNST------------ 406

  Fly   228 SKKAWIFVPCHGMTNCSNNRSIIAEDKDQLDF-----VNVRMEQEGWYTC--VESNSLGQSNSTA 285
                              :|..: |.||:..|     |.:.:....:.:.  :..|..||.:...
  Rat   407 ------------------SRDPV-EKKDETPFGVSVAVGLAVSAALFLSALLLVLNKCGQRSKFG 452

  Fly   286 YLRVVRSLHVL--EAGVASGSLHSTSFVYIFVFGGLIFIFMTTLFVFYAIRKMKHEKVLKQRIET 348
            ..|..    ||  |.|:|. |||                |||.                      
  Rat   453 INRPA----VLAPEDGLAM-SLH----------------FMTL---------------------- 474

  Fly   349 VHQWTKKVIIFKPEGG-------GDSSGSMDTMIMPVVRIQKQRTTVLQNGNEPAPFNEYEFPLD 406
                          ||       |..||           :|..   :::|   |..|::     .
  Rat   475 --------------GGSSLSPTEGKGSG-----------LQGH---IMEN---PQYFSD-----T 503

  Fly   407 SNWELPRSHLVLGATLGEGAFGRVVMAEVNN-------AIVAVKMVKEGHTDDDIASLVREMEVM 464
            ....:.|..::|...|||||||:|.:||..|       .:||||.:|| .:::......||.|::
  Rat   504 CVHHIKRQDIILKWELGEGAFGKVFLAECYNLLNDQDKMLVAVKALKE-TSENARQDFHREAELL 567

  Fly   465 KIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQD--RDSSQPPPSPPAHV 527
            .:: :|.:|:...|.|::.|||.::.||..||:|..||   |..|.|..  .......|.|    
  Rat   568 TML-QHQHIVRFFGVCTEGGPLLMVFEYMRHGDLNRFL---RSHGPDAKLLAGGEDVAPGP---- 624

  Fly   528 ITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTN 592
            :....|:..|.|:|.||.||||...:|||||.||.||....|:||.|||::|||.||||||....
  Rat   625 LGLGQLLAVASQVAAGMVYLASLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGR 689

  Fly   593 GRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPA 657
            ..|||:||.|||:..:.:.::|||||:|::||||.|||:||:..:.:.|.: ..:..|:.:|:|.
  Rat   690 TMLPIRWMPPESILYRKFSTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAI-ECITQGRELERPR 753

  Fly   658 KCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKLLQTKEDYLDV 701
            .|..::|.:||.||......|....::...:..|.|....||||
  Rat   754 ACPPDVYAIMRGCWQREPQQRLSMKDVHARLQALAQAPPSYLDV 797

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
htlNP_524394.2 Ig 101..191 CDD:472250 20/106 (19%)
Ig strand B 121..125 CDD:409353 0/3 (0%)
Ig strand C 134..138 CDD:409353 0/3 (0%)
Ig strand E 157..161 CDD:409353 1/3 (33%)
Ig strand F 171..176 CDD:409353 3/4 (75%)
Ig strand G 184..187 CDD:409353 0/2 (0%)
Ig 200..289 CDD:472250 15/96 (16%)
Ig strand B 216..220 CDD:409353 0/3 (0%)
Ig strand C 229..233 CDD:409353 0/3 (0%)
Ig strand E 255..259 CDD:409353 1/3 (33%)
Ig strand F 269..274 CDD:409353 0/6 (0%)
Ig strand G 282..285 CDD:409353 0/2 (0%)
Protein Kinases, catalytic domain 404..692 CDD:473864 109/296 (37%)
Ntrk1NP_067600.1 leucine-rich repeat 68..92 CDD:275378
LRR 1 90..113
LRR_8 92..150 CDD:404697
leucine-rich repeat 93..116 CDD:275378
LRR 2 116..137
leucine-rich repeat 117..139 CDD:275378
leucine-rich repeat 140..152 CDD:275378
LRRCT_2 151..194 CDD:465313
Ig 197..284 CDD:472250 22/95 (23%)
Ig strand B 213..217 CDD:409353 2/3 (67%)
Ig strand C 226..230 CDD:409353 0/3 (0%)
Ig strand E 249..253 CDD:409353 2/3 (67%)
Ig strand F 264..269 CDD:409353 0/10 (0%)
Ig strand G 277..280 CDD:409353 0/2 (0%)
IgI_TrKABC_d5 287..382 CDD:409360 20/119 (17%)
Ig strand A 287..293 CDD:409360 0/5 (0%)
Ig strand A' 295..298 CDD:409360 0/2 (0%)
Ig strand B 301..309 CDD:409360 2/25 (8%)
Ig strand C 312..319 CDD:409360 2/6 (33%)
Ig strand C' 322..325 CDD:409360 1/2 (50%)
Ig strand D 330..336 CDD:409360 0/5 (0%)
Ig strand E 344..352 CDD:409360 2/7 (29%)
Ig strand F 360..368 CDD:409360 4/7 (57%)
Ig strand G 371..379 CDD:409360 1/7 (14%)
Interaction with SQSTM1 472..493 8/70 (11%)
Protein Kinases, catalytic domain 507..786 CDD:473864 109/288 (38%)
Blue background indicates that the domain is not in the aligned region.

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