DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment htl and fgfr3

DIOPT Version :9

Sequence 1:	NP_524394.2	Gene:	htl / 42160	FlyBaseID:	FBgn0010389	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	XP_021336328.1	Gene:	fgfr3 / 58129	ZFINID:	ZDB-GENE-000816-1	Length:	821	Species:	Danio rerio

Alignment Length:	745	Identity:	289/745 - (38%)
Similarity:	414/745 - (55%)	Gaps:	75/745 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 GSLVVL------FLLLSIWQ---PAVQVEGRRQMANSQEMI-----KDH--LGARSQNKTPAITN 67
            |..|||      |||..:||   .||....|.::......|     :|.  ...|..:|:..::|
Zfish    67 GDTVVLSCTPQDFLLPIVWQKDGDAVSSSNRTRVGQKALRIINVSYEDSGVYSCRHAHKSMLLSN 131

  Fly    68 NANQSSTSSADLDDGAADDDDNKADLPVNVSSK-PYW-RNPKKMSFLQTRPSGSLLTLNCHALGN 130
            ...:...|.:..||...|:|:::|.   |.::: ||| |:.:....|...|:.:.:...|.|.||
Zfish   132 YTVKVIDSLSSGDDEDYDEDEDEAG---NGNAEAPYWTRSDRMEKKLLAVPAANTVKFRCPAAGN 193

  Fly   131 PEPNITWYRNGTV---DWTRGYGSLKRNRWTLTMEDLVPGDCGNYTCKVCNSLGCIRHDTQVIVS 192
            |.|:|.|.:||..   :...|...|:..:|:|.||..||.|.|||||.|.|..|.|:|..|:.|.
Zfish   194 PTPSIHWLKNGKEFKGEQRMGGIKLRDQQWSLVMESAVPSDRGNYTCVVQNKYGTIKHTYQLDVL 258

  Fly   193 DRVNHKPILMTG-PLNLTLVVNSTGSMHCKYLSDLTSKKAWI-FVPCHG---------MTNCSNN 246
            :|..|:|||..| |.|.|:||.|....|||..||......|: .:..:|         ..|....
Zfish   259 ERSPHRPILQAGLPANQTVVVGSDVEFHCKVYSDAQPHIQWLKHIEVNGSQYGPNGAPYVNVLKT 323

  Fly   247 RSIIAEDKDQ--LDFVNVRMEQEGWYTCVESNSLGQSNSTAYLRVVRSLHV-LEAGVASGSLHST 308
            ..|...||:.  |...||..|..|.|||:..||:|.::.:|:|.|:.::.: .|...|...::.|
Zfish   324 AGINTTDKELEILYLTNVSFEDAGQYTCLAGNSIGYNHHSAWLTVLPAVEMEREDDYADILIYVT 388

  Fly   309 SFVYIFVFGGLIFIFMTTLFVFYAIRK-MKHEKVL-KQRIETVHQW-TKKVIIFKPEGGGDSSGS 370
            |.|          :|:.|:.:....|. :..:|.| ...::.:.:: .|:.:....|  .:||.:
Zfish   389 SCV----------LFILTMVIIILCRMWINTQKTLPAPPVQKLSKFPLKRQVTVSLE--SNSSMN 441

  Fly   371 MDTMIMPVVRIQKQRTTVLQNGNEPAPFNEYEFPLDSNWELPRSHLVLGATLGEGAFGRVVMAEV 435
            .:|.::.:.|:......:|.|      .:|.|.|.|..||..|:.|.||..||||.||:|||||.
Zfish   442 SNTPLVRIARLSSSDGPMLPN------VSELELPSDPKWEFTRTKLTLGKPLGEGCFGQVVMAEA 500

  Fly   436 --------NNAI-VAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQNGPLYVIVE 491
                    |..: |||||:|:..||.|::.||.|||:||:||:|.|||||||.|:|:|||||:||
Zfish   501 IGIDKEKPNKPLTVAVKMLKDDGTDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVLVE 565

  Fly   492 YAPHGNLKDFLYKNRPFGRDQDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHRD 556
            ||..|||:::|...||.|.|...|:.:    .|...:|.|||:..|:|:||||:||||::|||||
Zfish   566 YASKGNLREYLRARRPPGMDYSFDTCK----IPNETLTFKDLVSCAYQVARGMEYLASKKCIHRD 626

  Fly   557 LAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGI 621
            ||||||||::|.|:||||||||||:.:.|||:|.||||||:||||||:|.::.|..:|||||||:
Zfish   627 LAARNVLVTEDNVMKIADFGLARDVHNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSYGV 691

  Fly   622 LLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVE 686
            |||||.|.|..|||.| ..|||:..|..|.||:|||.|:..:|::||:|||.....||.|.::||
Zfish   692 LLWEIFTLGGSPYPGI-PVEELFKLLKEGHRMDKPANCTHELYMIMRECWHAVPSQRPTFRQLVE 755

  Fly   687 YMDKLLQ--TKEDYLDVDIANLDTPPSTSD 714
            ..|::|.  :.::|||:.:......|:..|
Zfish   756 DHDRVLSMTSTDEYLDLSVPFEQYSPTCPD 785

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	112..191	CDD:299845	32/81 (40%)
		IG_like	113..191	CDD:214653	31/80 (39%)
		IG_like	205..289	CDD:214653	30/95 (32%)
		PKc_like	404..692	CDD:304357	165/296 (56%)
		STYKc	416..688	CDD:214568	159/280 (57%)
fgfr3	XP_021336328.1	IGc2	67..121	CDD:197706	14/53 (26%)
		Ig2_FGFR	173..257	CDD:143265	32/83 (39%)
		Ig3_FGFR-2	280..369	CDD:143266	25/88 (28%)
		PTKc_FGFR3	468..801	CDD:173652	171/323 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	321	1.000	Domainoid score	I1203
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55437
Inparanoid	1	1.050	460	1.000	Inparanoid score	I1538
OMA	1	1.010	-	-		QHG50158
OrthoDB	1	1.010	-	-		D119660at33208
OrthoFinder	1	1.000	-	-		FOG0000923
OrthoInspector	1	1.000	-	-		mtm6455
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6544
SonicParanoid	1	1.000	-	-		X537
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.770