Protein Alignment htl and PTK6

DIOPT Version :10

• Sequence 1: NP_524394.2
• Gene: htl / 42160
• FlyBaseID: FBgn0010389
• Length: 729
• Species: Drosophila melanogaster
• Sequence 2: NP_005966.1
• Gene: PTK6 / 5753
• HGNCID: 9617
• Length: 451
• Species: Homo sapiens
• Alignment Length: 438
• Identity: 135/438 - (30%)
• Similarity: 203/438 - (46%)
• Gaps: 86/438 - (19%)

  Fly   264 MEQEGW-YTCVESNSLGQSNSTAYLRVVRSLHVLEAGVASGSLHSTSFVYIFVFGGLIFIFMTTL 327
            :|.|.| :.|:       |.|.|    ||.|..  .|.|:|:
Human    73 VESEPWFFGCI-------SRSEA----VRRLQA--EGNATGA----------------------- 101

  Fly   328 FVFYAIRKMKHEKVLKQRIETVHQWTKKVIIFKPEGGG-DSSGSMDTMIMPVVRIQKQRTTVLQN 391
            |:.....|...:.||..| :|  |..:...|::..||. ..:.::..:.:|.: :...|...|.:
Human   102 FLIRVSEKPSADYVLSVR-DT--QAVRHYKIWRRAGGRLHLNEAVSFLSLPEL-VNYHRAQSLSH 162

  Fly   392 G---------NEPAPFNEYEFPLDSNWELPRSHLVLGATLGEGAFGRVVMAEVNNAI-VAVKMVK 446
            |         :||.|...::     :||.||....|...||.|.||.|......:.: ||:|::.
Human   163 GLRLAAPCRKHEPEPLPHWD-----DWERPREEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVIS 222

  Fly   447 EGHTDDDI---ASLVREMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPF 508
            .    |::   ..|..|::.||.: ||.:|:.|....|...|:|:|.|....|:|.:.|
Human   223 R----DNLLHQQMLQSEIQAMKKL-RHKHILALYAVVSVGDPVYIITELMAKGSLLELL------ 276

  Fly   509 GRDQDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIA 573
                 |||.:       .|:...:|:..|.|:|.||.||.|:..|||||||||:||.::.:.|:.
Human   277 -----RDSDE-------KVLPVSELLDIAWQVAEGMCYLESQNYIHRDLAARNILVGENTLCKVG 329

  Fly   574 DFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIM 638
            ||||||.|:...|...:.|  :|.||.|||:|....|.:||||||:||||.|:.:.||.|||. |
Human   330 DFGLARLIKEDVYLSHDHN--IPYKWTAPEALSRGHYSTKSDVWSFGILLHEMFSRGQVPYPG-M 391

  Fly   639 SAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVE 686
            |..|.:..:.:|.||..|.:|..:::.||..||..:.:.||.|..:.|
Human   392 SNHEAFLRVDAGYRMPCPLECPPSVHKLMLTCWCRDPEQRPCFKALRE 439

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	101..191	CDD:472250
		Ig strand B	121..125	CDD:409353
		Ig strand C	134..138	CDD:409353
		Ig strand E	157..161	CDD:409353
		Ig strand F	171..176	CDD:409353
		Ig strand G	184..187	CDD:409353
		Ig	200..289	CDD:472250	7/25 (28%)
		Ig strand B	216..220	CDD:409353
		Ig strand C	229..233	CDD:409353
		Ig strand E	255..259	CDD:409353
		Ig strand F	269..274	CDD:409353	2/5 (40%)
		Ig strand G	282..285	CDD:409353	1/2 (50%)
		Protein Kinases, catalytic domain	404..692	CDD:473864	105/287 (37%)
PTK6	NP_005966.1	SH3_Brk	12..69	CDD:212781
		SH2_PTK6_Brk	75..174	CDD:198221	26/138 (19%)
		Linker	171..190		7/23 (30%)
		PTKc_Srm_Brk	184..444	CDD:133248	105/282 (37%)