Protein Alignment htl and ltk

DIOPT Version :10

• Sequence 1: NP_524394.2
• Gene: htl / 42160
• FlyBaseID: FBgn0010389
• Length: 729
• Species: Drosophila melanogaster
• Sequence 2: NP_001006661.2
• Gene: ltk / 564470
• ZFINID: ZDB-GENE-030616-115
• Length: 1530
• Species: Danio rerio
• Alignment Length: 670
• Identity: 170/670 - (25%)
• Similarity: 255/670 - (38%)
• Gaps: 206/670 - (30%)

  Fly    79 LDDGAADDDDNKADLPVNVSSKPYWRNPKKMSFLQTRPSGSLLTLNCHALGNPEPNITWYRNGTV 143
            |||.:||..|..:           :.:|....|||     .|..:..|.    |..|..|.|
Zfish   735 LDDISADGQDGLS-----------FVHPMGKIFLQ-----PLAAMESHG----EAEIVVYLN--- 776

  Fly   144 DWTRGYGSLKRNRWTLTMEDLVPGDCGNYTCKVCNSLGCIR-HDTQVIV----SDRVNHKPILMT 203
                                          |..|.:..|.| .||::|:    ||.|       .
Zfish   777 ------------------------------CSHCKTQSCKRDEDTKLILCLCDSDEV-------L 804

  Fly   204 GPLNLTLVVNSTGSMHCKYLSDLTSKKAWIFVPCHGMTNCSNNRSIIAEDKDQLDFVNVRMEQEG 268
            .|.|:|                                 |:..:..:.:      |:|..:
Zfish   805 APDNVT---------------------------------CAGTKHSLCQ------FINKHL---- 826

  Fly   269 WYTCVESNSLGQSNSTAYLRVVRSLHVLEAGVASGSLHSTSFVYIF------VFGGLIFIFMTTL 327
                       |.||:..  |...|.|....:|.|   ..|.|:|.      |..|::....:..
Zfish   827 -----------QHNSSPL--VCPPLVVPMGSLADG---PPSLVFIMAGIVSTVVTGVVLTCASLT 875

  Fly   328 FVFYAIRKMKHEKVLKQRIETVHQWTKKVIIFKPEGGGDSSGSMDTMIMPVVRIQKQRTTVLQNG 392
            .::|  ||..|...::.|:::                            |..::.|.|::.:...
Zfish   876 LIYY--RKKNHLHAVRIRLQS----------------------------PEYKLSKIRSSTIMTD 910

  Fly   393 NEP--------APFNEYEFPLDSNWELPRSHLVLGATLGEGAFGRVVMAEV------NNAI-VAV 442
            ..|        |..:|.:       |:||.::.|...||.||||.|...:|      |.|: ||:
Zfish   911 YNPNYGYFGKAASLSELK-------EVPRKNITLLRALGHGAFGEVYEGQVLGMNGENTAMQVAI 968

  Fly   443 KMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRP 507
            |.:.|..::.|....:.|..:|.... |.||:..:|...|..|.::::|....|::|.||..|||
Zfish   969 KTLPEICSEQDEMDFLMEALIMSKFS-HQNIVRCIGVSLQILPRFILLELMTGGDMKSFLRLNRP 1032

  Fly   508 FGRDQDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVS---DDYV 569
                :...||.         ::..:|:..|..||.|..||.....||||:||||.|::   .|.|
Zfish  1033 ----RTNHSSS---------LSMLELLHMARDIALGCRYLEENHFIHRDIAARNCLLTCPGPDRV 1084

  Fly   570 LKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPY 634
            .||.|||:||||....||||.....||:|||.||:..|..:..|:|.||:|:|||||.:.|..||
Zfish  1085 AKIGDFGMARDIYRASYYRKGGRAMLPVKWMPPEAFLEGIFTCKTDTWSFGVLLWEIFSLGYMPY 1149

  Fly   635 PTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKLLQTKEDYL 699
            | ..:.:|:..::..|.||:.|..|...:|.:|.|||....:.||.||.|:|.::...|
Zfish  1150 P-CKTNQEVLEFVTGGGRMDPPKSCPGPVYRIMTQCWQHCPEHRPNFTTILERINYCTQ------ 1207

  Fly   700 DVDIANLDTPPSTSDEEEDE 719
            |.|:.|...|.......|:|
Zfish  1208 DPDVINTPLPVECGPPVEEE 1227

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	101..191	CDD:472250	16/90 (18%)
		Ig strand B	121..125	CDD:409353	0/3 (0%)
		Ig strand C	134..138	CDD:409353	1/3 (33%)
		Ig strand E	157..161	CDD:409353	0/3 (0%)
		Ig strand F	171..176	CDD:409353	1/4 (25%)
		Ig strand G	184..187	CDD:409353	1/3 (33%)
		Ig	200..289	CDD:472250	9/88 (10%)
		Ig strand B	216..220	CDD:409353	0/3 (0%)
		Ig strand C	229..233	CDD:409353	0/3 (0%)
		Ig strand E	255..259	CDD:409353	0/3 (0%)
		Ig strand F	269..274	CDD:409353	0/4 (0%)
		Ig strand G	282..285	CDD:409353	2/2 (100%)
		Protein Kinases, catalytic domain	404..692	CDD:473864	107/297 (36%)
ltk	NP_001006661.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	635..671
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1313..1334
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1389..1420
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1492..1530