DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment htl and si:ch73-206d17.1

DIOPT Version :9

Sequence 1:	NP_524394.2	Gene:	htl / 42160	FlyBaseID:	FBgn0010389	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	XP_689652.2	Gene:	si:ch73-206d17.1 / 561155	ZFINID:	ZDB-GENE-090313-143	Length:	393	Species:	Danio rerio

Alignment Length:	405	Identity:	103/405 - (25%)
Similarity:	177/405 - (43%)	Gaps:	93/405 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   389 LQNGNEPAPFNEYEFPL-------------------------------------DSNWELPRSHL 416
            :.:|::||.::|...||                                     .||.. .|.|:
Zfish     9 ISSGSDPACYDEGSGPLAVIIIPSLLALSTLIVVSQIIWSFVTKRSSAQKITSSSSNVN-EREHV 72

  Fly   417 VLGATLGE--------------------------GAFGRVVMAEV----NNAIVAVKMVKEGHTD 451
            .|.|.:|.                          |.:|.:.|.::    .:..|.:|.:|:..|.
Zfish    73 QLDAGIGSLRPANVLGPLELPVQCTLEGVEVLQMGRYGPICMGQLKQDNTSTAVMIKTLKDRSTQ 137

  Fly   452 DDIASLVREMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDS 516
            .:.|..:..:.....:.:|.||:.||.|.::..|:|:::|.:..|||.:||:..|   .|:..:|
Zfish   138 SESAEFMDLVLFHAAVSKHENIVKLLFCQTRRTPMYLLLEASVPGNLLNFLWSLR---EDRCGES 199

  Fly   517 SQPPPSPPAHVITEKDLIKFAHQIARGMDYLAS-RRCIHRDLAARNVLVSDDYVLKIADFGLARD 580
            |         |.:||.:...|.|||.|:|||.| .|.||.|:||||:|:...:.:|::....|.:
Zfish   200 S---------VFSEKSVFLVAKQIAAGLDYLHSHHRVIHGDVAARNMLIGSAFSVKVSGLDFAFE 255

  Fly   581 IQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYT 645
            .:......:.....:|:||.|||.:.......:|||||:||||:|::|.|..|||. :...|:..
Zfish   256 SRQKKKVDREQEANVPVKWQAPERMMRLPLTDRSDVWSFGILLYEMITLGSPPYPD-LDPSEVLP 319

  Fly   646 YLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKLLQTKEDYLDVDIANLDTPP 710
            ..::..||::|..|...::.|::.|..:|..|||.::.|:..:|..     .|.      .||.|
Zfish   320 RTLAHYRMKRPENCGAPLFDLIKYCCMWNFKDRPVYSAIIRLLDSY-----SYF------ADTKP 373

  Fly   711 STSDEEEDETDNLQK 725
            ..|:.:.|.::..:|
Zfish   374 LCSEVQIDVSEYKKK 388

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	112..191	CDD:299845
		IG_like	113..191	CDD:214653
		IG_like	205..289	CDD:214653
		PKc_like	404..692	CDD:304357	92/355 (26%)
		STYKc	416..688	CDD:214568	85/302 (28%)
si:ch73-206d17.1	XP_689652.2	PKc_like	102..363	CDD:304357	82/273 (30%)
si:ch73-206d17.1	XP_689652.2	Pkinase_Tyr	102..362	CDD:285015	82/272 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810