DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment htl and kdr

DIOPT Version :10

Sequence 1:NP_524394.2 Gene:htl / 42160 FlyBaseID:FBgn0010389 Length:729 Species:Drosophila melanogaster
Sequence 2:NP_001019824.2 Gene:kdr / 554230 ZFINID:ZDB-GENE-041001-112 Length:1357 Species:Danio rerio


Alignment Length:687 Identity:202/687 - (29%)
Similarity:295/687 - (42%) Gaps:178/687 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   134 NITWYR---------------------------NGTVDWTRGYGSLKRNRWTLTMEDLVPG---- 167
            |:.|||                           |.||...:|        ..:|::..:|.    
Zfish   588 NLRWYRVANVANHDPPPAAVPCDTLTLSHLHQPNVTVSGLQG--------TNVTLDMPIPNATMM 644

  Fly   168 DCGNYTCKV----CNSLGCIRHDTQVIVSDRVNHKPILMTGPLNLTLVVNSTGSMHCKYLSDLTS 228
            |.|.|.|:|    .|...|:.|:.::    |......::|...:..:.|:.:.::.|:.....|.
Zfish   645 DQGLYACQVEIVGTNEKTCLLHNLRL----RALEMSRIVTNLTDQRVNVSDSTTLVCEVSGTPTP 705

  Fly   229 KKAWIFVPCHGMTNCSNNRSIIAEDKDQLDFVNVRMEQEGWYTCVESNSLGQSNSTAYLRVVRSL 293
            ...|   .....|....:..|:......|....|:.|..|.|.|...|..|..:|.|.:.|    
Zfish   706 TIVW---TKDNQTVMEGSGVILKRSNRVLTIQRVKKEDSGLYICTACNQQGCESSEARISV---- 763

  Fly   294 HVLEAGVASGSLHSTSFVYIFVFGGLIFIFMTTLFVFYAIRKMKHEKVLKQRIETVHQWTKKVII 358
                    .|:....:...|...|.::......|.:.:.||..|                     
Zfish   764 --------DGAEEKMNVELIMPIGAVVIAMFLWLLIVFVIRNRK--------------------- 799

  Fly   359 FKPEGGGDSSGSMDTMIMPVVRIQKQRTTVLQNGNEPAPFNEY--EFPLD-SNWELPRSHLVLGA 420
             :|..|...:|.:..::                .::..|.:|:  ....| |.||.||..|.||.
Zfish   800 -RPNDGDLKTGYLSIIL----------------DSDDMPMDEHCERLTYDASKWEFPRDRLKLGE 847

  Fly   421 TLGEGAFGRVVMAEVNN-------AIVAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLG 478
            .||.||||:||.|....       ..|||||:|||.|..:..:|:.|::::..||.|:|::||||
Zfish   848 PLGRGAFGQVVEATAYGIEKATTCTTVAVKMLKEGATSSEYRALMSELKILIHIGHHLNVVNLLG 912

  Fly   479 CCS-QNGPLYVIVEYAPHGNLKDFL---------YKNR----PFGRD--QDRD------------ 515
            .|: |.|||.|||||..||||..:|         ||.|    |..|:  ||.|            
Zfish   913 ACTKQGGPLMVIVEYCKHGNLSSYLKSKRGEYSPYKKRTPRMPNRREVQQDEDPREGDLGLGTST 977

  Fly   516 ----------------------SSQPPPSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLA 558
                                  ..:...|...| :|.:|||.::.|:|:||::||||:|||||||
Zfish   978 RLDICTGTAVCTRTGEQTSTTLQDEQESSDWDH-LTMEDLISYSFQVAKGMEFLASRKCIHRDLA 1041

  Fly   559 ARNVLVSDDYVLKIADFGLARDI-QSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGIL 622
            |||:|:|::.|:||.|||||||: :..||.||. :.|||:||||||::.::.|.::|||||:|:|
Zfish  1042 ARNILLSENSVVKICDFGLARDVYKDPDYVRKG-DARLPLKWMAPETIFDRVYTTQSDVWSFGVL 1105

  Fly   623 LWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEY 687
            ||||.:.|..|||.:...|.....|..|.||..|...:..||..|..||.....|||.||::||:
Zfish  1106 LWEIFSLGASPYPGVCIDESFCRRLKEGTRMRAPDYATPEIYQTMLDCWLDRPLDRPTFTQLVEH 1170

  Fly   688 MDKLLQTK-----EDYLDVDIANLDTPPSTSDEEEDE 719
            :..|||..     :||:          |.|:.|.|:|
Zfish  1171 LGNLLQASAQQDGKDYI----------PLTNGEMEEE 1197

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
htlNP_524394.2 Ig 101..191 CDD:472250 18/91 (20%)
Ig strand B 121..125 CDD:409353
Ig strand C 134..138 CDD:409353 1/3 (33%)
Ig strand E 157..161 CDD:409353 0/3 (0%)
Ig strand F 171..176 CDD:409353 2/4 (50%)
Ig strand G 184..187 CDD:409353 1/2 (50%)
Ig 200..289 CDD:472250 17/88 (19%)
Ig strand B 216..220 CDD:409353 0/3 (0%)
Ig strand C 229..233 CDD:409353 0/3 (0%)
Ig strand E 255..259 CDD:409353 1/3 (33%)
Ig strand F 269..274 CDD:409353 2/4 (50%)
Ig strand G 282..285 CDD:409353 1/2 (50%)
Protein Kinases, catalytic domain 404..692 CDD:473864 143/346 (41%)
kdrNP_001019824.2 Ig 227..333 CDD:472250
Ig strand B 244..248 CDD:409448
Ig strand C 259..263 CDD:409448
Ig strand E 297..301 CDD:409448
Ig strand F 311..316 CDD:409448
Ig strand G 324..327 CDD:409448
Ig 336..429 CDD:472250
Ig strand B 356..360 CDD:409353
Ig strand C 369..373 CDD:409353
Ig strand E 393..397 CDD:409353
Ig strand F 407..412 CDD:409353
Ig strand G 422..425 CDD:409353
IG_like 571..654 CDD:214653 14/73 (19%)
I-set 677..763 CDD:400151 17/88 (19%)
Ig strand B 694..697 CDD:409353 0/2 (0%)
Ig strand C 706..710 CDD:409353 1/6 (17%)
Ig strand E 729..733 CDD:409353 1/3 (33%)
Ig strand F 743..748 CDD:409353 2/4 (50%)
VEGFR-2_TMD 768..802 CDD:375470 6/55 (11%)
Protein Kinases, catalytic domain 835..1178 CDD:473864 144/344 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 944..975 8/30 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1296..1357
Blue background indicates that the domain is not in the aligned region.

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