DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment htl and STYK1

DIOPT Version :9

Sequence 1:	NP_524394.2	Gene:	htl / 42160	FlyBaseID:	FBgn0010389	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_060893.2	Gene:	STYK1 / 55359	HGNCID:	18889	Length:	422	Species:	Homo sapiens

Alignment Length:	373	Identity:	102/373 - (27%)
Similarity:	176/373 - (47%)	Gaps:	64/373 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   381 IQKQRTTVLQNGNE---PAPFNEYEFPLDSNWE--------LPRSHL----VLGAT--------- 421
            |::|||...::|.:   |.|     .|.|.:||        ||....    .||||
Human    49 IREQRTQQQRSGPQGIAPVP-----PPRDLSWEAGHGGNVALPLKETSVENFLGATTPALAKLQV 108

  Fly   422 ----LGE-------GAFGRVVMAEVNNA------IVAVKMVKEGHTDDDIASLVREMEVMKIIGR 469
                |.|       |:.|.:..|.:|..      .|.:|.:||.....::...:..::..:.:|:
Human   109 PREQLSEVLEQICSGSCGPIFRANMNTGDPSKPKSVILKALKEPAGLHEVQDFLGRIQFHQYLGK 173

  Fly   470 HINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRD-QDRDSSQPPPSPPAHVITEKDL 533
            |.|::.|.|||::..|||:::|....|:|..||:..|   || ...|..       .:.:|||.:
Human   174 HKNLVQLEGCCTEKLPLYMVLEDVAQGDLLSFLWTCR---RDVMTMDGL-------LYDLTEKQV 228

  Fly   534 IKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRK--NTNGRLP 596
            .....|:...:::|..:...|.|:||||:|:..|...|:...|||.::    |.|.  ::...:|
Human   229 YHIGKQVLLALEFLQEKHLFHGDVAARNILMQSDLTAKLCGLGLAYEV----YTRGAISSTQTIP 289

  Fly   597 IKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSM 661
            :||:|||.|..:....::||||:||||:|::|.|..|||.: ....:..:|...:.|::|:.|:.
Human   290 LKWLAPERLLLRPASIRADVWSFGILLYEMVTLGAPPYPEV-PPTSILEHLQRRKIMKRPSSCTH 353

  Fly   662 NIYILMRQCWHFNADDRPPFTEIVEYMDKLLQTKEDYLDVDIANLDTP 709
            .:|.:|:.||.:...|||...|:...::..::|.:|...:.:..|..|
Human   354 TMYSIMKSCWRWREADRPSPRELRLRLEAAIKTADDEAVLQVPELVVP 401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	112..191	CDD:299845
		IG_like	113..191	CDD:214653
		IG_like	205..289	CDD:214653
		PKc_like	404..692	CDD:304357	91/328 (28%)
		STYKc	416..688	CDD:214568	85/304 (28%)
STYK1	NP_060893.2	Pkinase_Tyr	117..380	CDD:285015	79/277 (29%)
STYK1	NP_060893.2	PKc_like	118..381	CDD:304357	79/277 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810