DRSC/TRiP Functional Genomics Resources

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Protein Alignment htl and fgfr4

DIOPT Version :10

Sequence 1:NP_524394.2 Gene:htl / 42160 FlyBaseID:FBgn0010389 Length:729 Species:Drosophila melanogaster
Sequence 2:XP_012814458.2 Gene:fgfr4 / 549077 XenbaseID:XB-GENE-478699 Length:847 Species:Xenopus tropicalis


Alignment Length:683 Identity:269/683 - (39%)
Similarity:371/683 - (54%) Gaps:68/683 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly    73 STSSADLDDGAADDD----DNKADL---PVNVSSKPYWRNPKKM-SFLQTRPSGSLLTLNCHALG 129
            |.:|.|.:|   |:|    |:.||:   ||.....|||..|.:| ..|...|:|:.:...|.|.|
 Frog   156 SLASGDEED---DEDGRREDSAADINEEPVYFFQAPYWTQPHRMDKKLHAVPAGNTVKFRCPAGG 217

  Fly   130 NPEPNITWYRNGTV---DWTRGYGSLKRNRWTLTMEDLVPGDCGNYTCKVCNSLGCIRHDTQVIV 191
            :|.|.|.|.:||..   :...|...|:...|:|.||.:||.|.|||||.|.|.:|.:.:...:.|
 Frog   218 SPLPTIRWLKNGREFRGEHRIGGIQLRHQHWSLVMESVVPSDRGNYTCVVENRIGSLTYTYFLDV 282

  Fly   192 SDRVNHKPILMTG-PLNLTLVVNSTGSMHCKYLSDLTSKKAWI-FVPCHG---------MTNCSN 245
            .:|.:|:|||..| |.|.|..|.|....:||..||......|: .:..:|         ......
 Frog   283 LERSSHRPILQAGLPANTTARVGSDVEFYCKVYSDAQPHIQWLKHIEVNGSRFGPDDFPYVQVLK 347

  Fly   246 NRSIIAEDKDQLDFVNVRMEQEGWYTCVESNSLGQSNSTAYLRVVRSLHVLEAGVASGSLHSTSF 310
            ...|...:.:.|...|:.||..|.|||:..||:|.|:.:|:|.|:.|...||....:.|.:....
 Frog   348 TADINTSEVEVLHLRNITMEDAGEYTCLAGNSIGLSHQSAWLIVLPSEDFLEQAEPAESRYMDII 412

  Fly   311 VYIFVFGGLIFIFMTTLFVFYAIRKMKHEKVLKQRIETVHQWTKKVIIFKPEGGGDSSGSMDTMI 375
            :|.   .|.:.:.|..:.|.....:..|.|...|. .|||:..|..:|.:......|||.....:
 Frog   413 IYT---SGFLAVAMAIVIVVLCRMQTPHSKQTLQP-PTVHKLAKFPLIRQFSLESSSSGKSSAPL 473

  Fly   376 MPVVRIQKQRTTVLQNGNEPAPFNEYEFPLDSNWELPRSHLVLGATLGEGAFGRVVMAE------ 434
            :.:.|:......:|..      ..|.|.|||:.||.||..||||..||||.||:||.||      
 Frog   474 IRITRLSSSCAPMLPG------VMEVELPLDAKWEFPRDRLVLGKPLGEGCFGQVVRAEGYGIDK 532

  Fly   435 ---VNNAIVAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPHG 496
               .....|||||:|:..||.|::.|:.|||:||:||:|.|||||||.|:|.|||:||||||..|
 Frog   533 ERPEKPVTVAVKMLKDNGTDKDLSDLISEMELMKVIGKHKNIINLLGVCTQEGPLFVIVEYASKG 597

  Fly   497 NLKDFLYKNRPFGRDQDRDSSQPPPSP---------PAHVITEKDLIKFAHQIARGMDYLASRRC 552
            ||::||...|             ||:|         |..:::.|||:..|:|:||||:||.|:||
 Frog   598 NLREFLRARR-------------PPTPEDAFDITKVPEELLSFKDLVSCAYQVARGMEYLESKRC 649

  Fly   553 IHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVW 617
            ||||||||||||::|.|:|||||||||.:...|||:|.:|||||:||||||:|.::.|..:||:|
 Frog   650 IHRDLAARNVLVAEDNVMKIADFGLARGVHDIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDIW 714

  Fly   618 SYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFT 682
            |:|:|.|||.|.|..|||.| ..|||:..|..|.||:||:.|:..:|:|||:|||.....||.|.
 Frog   715 SFGVLTWEIFTLGGSPYPGI-PVEELFKLLREGHRMDKPSNCTHELYMLMRECWHAVPSQRPTFK 778

  Fly   683 EIVEYMDKLL-QTKEDYLDVDIANLDTPPSTSD 714
            ::||.:|::| ...|:|||:.:......||..|
 Frog   779 QLVEQLDRILTAVSEEYLDLSMPFEQYSPSCED 811

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
htlNP_524394.2 Ig 101..191 CDD:472250 34/93 (37%)
Ig strand B 121..125 CDD:409353 0/3 (0%)
Ig strand C 134..138 CDD:409353 1/3 (33%)
Ig strand E 157..161 CDD:409353 2/3 (67%)
Ig strand F 171..176 CDD:409353 4/4 (100%)
Ig strand G 184..187 CDD:409353 0/2 (0%)
Ig 200..289 CDD:472250 29/99 (29%)
Ig strand B 216..220 CDD:409353 0/3 (0%)
Ig strand C 229..233 CDD:409353 0/3 (0%)
Ig strand E 255..259 CDD:409353 1/3 (33%)
Ig strand F 269..274 CDD:409353 3/4 (75%)
Ig strand G 282..285 CDD:409353 0/2 (0%)
Protein Kinases, catalytic domain 404..692 CDD:473864 159/305 (52%)
fgfr4XP_012814458.2 Ig strand B 308..312 CDD:409353 0/3 (0%)
Ig strand C 321..325 CDD:409353 0/3 (0%)
Ig strand E 357..361 CDD:409353 1/3 (33%)
Ig strand F 371..376 CDD:409353 3/4 (75%)
Ig strand G 384..387 CDD:409353 0/2 (0%)
PTKc_FGFR4 495..808 CDD:133230 164/326 (50%)
Ig 56..142 CDD:472250
Ig strand B 88..92 CDD:409353
Ig strand C 97..103 CDD:409353
Ig strand E 120..124 CDD:409353
Ig strand F 134..139 CDD:409353
IgI_2_FGFR 188..282 CDD:409443 34/93 (37%)
Ig strand A 188..191 CDD:409443 2/2 (100%)
Ig strand A' 199..204 CDD:409443 1/4 (25%)
Ig strand B 208..216 CDD:409443 1/7 (14%)
Ig strand C 222..227 CDD:409443 2/4 (50%)
Ig strand C' 230..232 CDD:409443 0/1 (0%)
Ig strand D 241..244 CDD:409443 0/2 (0%)
Ig strand E 248..253 CDD:409443 2/4 (50%)
Ig strand F 262..269 CDD:409443 5/6 (83%)
Ig strand G 272..282 CDD:409443 1/9 (11%)
Ig 290..392 CDD:472250 30/101 (30%)
Blue background indicates that the domain is not in the aligned region.

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