DRSC/TRiP Functional Genomics Resources

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Protein Alignment htl and flt1

DIOPT Version :10

Sequence 1:NP_524394.2 Gene:htl / 42160 FlyBaseID:FBgn0010389 Length:729 Species:Drosophila melanogaster
Sequence 2:NP_001014829.3 Gene:flt1 / 544667 ZFINID:ZDB-GENE-050407-1 Length:1272 Species:Danio rerio


Alignment Length:781 Identity:229/781 - (29%)
Similarity:349/781 - (44%) Gaps:185/781 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 SWRASHSTITMTSGSLVVLFLLLSIWQPAVQVEGRRQMANSQEMIKDHLGARSQNKT-------P 63
            ||.|......:||....:|                 .:::.||:::      .:|||       .
Zfish   475 SWTAVRKKTGVTSTHNPIL-----------------TISHRQEVLE------GKNKTVGVLTVGE 516

  Fly    64 AITNNANQSSTSSADLDDGAADDDDNKADLPVNVSSKPYWRNPKKMSFLQTRPSGSLLTLNCHAL 128
            |:.:...:..||:....|        :.|:|..|:..   :.....|.::....|..|.|.|.|.
Zfish   517 ALVSGIYRCVTSNILGRD--------ELDIPFYVTDV---KEGLVASLVEEPREGGDLRLLCIAN 570

  Fly   129 GNPEPNITWYR--NGTVDWTRGY---GSLKRNRWTLT----MEDLVPGDCGNYTCKVCNSL--GC 182
            .:...:::|.|  :....|....   |.|...:::.|    :::|...|.|.|.|...:.|  ..
Zfish   571 RHLYSDLSWSRITSQITVWDEASGLDGELTEGQFSHTLHFGLKNLTARDSGTYRCSATHLLTGEH 635

  Fly   183 IRHDTQVIVSDRVNHKPILMTGPLNLTLVVNSTGSMHCKYLSDLTSKKAWIFVPCHGMTNCSNNR 247
            |..||.|.|:  |...|:|:....:.|:.|:::.::||....          ||...:|...|.|
Zfish   636 IHLDTAVEVT--VLQAPVLLGNLSDHTVNVSNSITLHCPARG----------VPQPHITWYKNQR 688

  Fly   248 SI-------IAEDKDQLDFVNVRMEQEGWYTCVESNSLGQSNSTAYLRVVRSLHVLEAGVASGSL 305
            .:       :..::..|....:.:|.:|:|||..:|..|...|:||:.|..|...|       ||
Zfish   689 KLQQVSGIMLFPEEGTLHIDRITVEDQGFYTCQATNQRGSVESSAYIWVQNSSESL-------SL 746

  Fly   306 HSTSFVYIFVFGGLIFIFMTTLFVFYAIRKMKHEKVLKQRIETVHQWTKKVIIFKPEGGGDSSGS 370
            ...:.....|...|.::.:|.|     |||:||                           .:|.:
Zfish   747 EIPTLACTCVVATLFWLLLTLL-----IRKLKH---------------------------PNSDN 779

  Fly   371 MDTMIMPVVRIQKQRTTVLQNGNEPAPFN----EYEFPLDSNWELPRSHLVLGATLGEGAFGRVV 431
            .....:|:         :|..|.||...:    :|:   .:.||.||..|.|...||.||||||:
Zfish   780 GKAEYLPI---------ILHPGEEPLVEHCDRLQYD---PAKWEFPRDRLKLEKPLGRGAFGRVM 832

  Fly   432 MAEV----NNA---IVAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQN-GPLYV 488
            .|..    |:|   .|||||:|:|.|..:..:|:.|::::..||.|||::||||.|::: |||.|
Zfish   833 QASAVGIGNSASCTTVAVKMLKDGATPSEHKALMTELKILNHIGHHINVVNLLGACTKSGGPLMV 897

  Fly   489 IVEYAPHGNLKDFLYKNRPF-------------------GR-----------------------D 511
            ||||...|||..:|...|..                   ||                       :
Zfish   898 IVEYCQFGNLSAYLKSKREVFLLNRVNKEEEGVMKEGCKGRLTSVSSRQSNASSGFSEERGEISE 962

  Fly   512 QDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFG 576
            :|.|.......|    :..:|||.::.|:||||::||||:||||||||||:|:|::.|:||.|||
Zfish   963 EDSDCLSELSDP----LLLEDLISYSFQVARGMEFLASRKCIHRDLAARNILLSNNNVVKICDFG 1023

  Fly   577 LARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAE 641
            ||||:.....|.:|.:.|||:|||||||:.:|.:.::|||||||:|||||.:.|..|||.:...|
Zfish  1024 LARDLYKDPDYVRNGDARLPLKWMAPESIFDKVFTTQSDVWSYGVLLWEIFSLGASPYPGLNMDE 1088

  Fly   642 ELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKLLQT-----KEDYLDV 701
            |....|..|.||..|...:..||.:|..||..|.:|||.||.:||.:..||||     .:||:.:
Zfish  1089 EFCRRLKHGTRMCSPQYSTPEIYSIMCACWENNPEDRPSFTTLVEILGDLLQTCVQQDGKDYIPL 1153

  Fly   702 D 702
            :
Zfish  1154 N 1154

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
htlNP_524394.2 Ig 101..191 CDD:472250 22/100 (22%)
Ig strand B 121..125 CDD:409353 2/3 (67%)
Ig strand C 134..138 CDD:409353 0/3 (0%)
Ig strand E 157..161 CDD:409353 1/7 (14%)
Ig strand F 171..176 CDD:409353 2/4 (50%)
Ig strand G 184..187 CDD:409353 0/2 (0%)
Ig 200..289 CDD:472250 21/95 (22%)
Ig strand B 216..220 CDD:409353 0/3 (0%)
Ig strand C 229..233 CDD:409353 0/3 (0%)
Ig strand E 255..259 CDD:409353 1/3 (33%)
Ig strand F 269..274 CDD:409353 3/4 (75%)
Ig strand G 282..285 CDD:409353 1/2 (50%)
Protein Kinases, catalytic domain 404..692 CDD:473864 138/337 (41%)
flt1NP_001014829.3 Ig 224..322 CDD:472250
Ig strand B 241..245 CDD:409353
Ig strand C 256..260 CDD:409353
Ig strand E 286..290 CDD:409353
Ig strand F 300..305 CDD:409353
Ig strand G 313..316 CDD:409353
IgI_VEGFR-1 325..416 CDD:409499
Ig strand A 325..329 CDD:409499
Ig strand A' 335..340 CDD:409499
Ig strand B 345..353 CDD:409499
Ig strand C 357..363 CDD:409499
Ig strand C' 365..368 CDD:409499
Ig strand D 374..378 CDD:409499
Ig strand E 380..385 CDD:409499
Ig strand F 393..402 CDD:409499
Ig strand G 405..416 CDD:409499
Ig_3 419..529 CDD:464046 13/76 (17%)
IG_like 558..646 CDD:214653 22/89 (25%)
Ig strand B 563..567 CDD:409353 2/3 (67%)
Ig strand C 576..580 CDD:409353 0/3 (0%)
Ig strand E 606..612 CDD:409353 1/5 (20%)
Ig strand F 622..627 CDD:409353 2/4 (50%)
I-set 650..733 CDD:400151 20/92 (22%)
Ig strand B 667..671 CDD:409353 0/3 (0%)
Ig strand C 680..684 CDD:409353 1/3 (33%)
Ig strand E 703..707 CDD:409353 1/3 (33%)
Ig strand F 717..722 CDD:409353 3/4 (75%)
Ig strand G 730..733 CDD:409353 1/2 (50%)
PTKc_VEGFR 809..1138 CDD:270647 138/332 (42%)
Blue background indicates that the domain is not in the aligned region.

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