DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment htl and flt1

DIOPT Version :9

Sequence 1:	NP_524394.2	Gene:	htl / 42160	FlyBaseID:	FBgn0010389	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_001014829.3	Gene:	flt1 / 544667	ZFINID:	ZDB-GENE-050407-1	Length:	1272	Species:	Danio rerio

Alignment Length:	781	Identity:	229/781 - (29%)
Similarity:	349/781 - (44%)	Gaps:	185/781 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 SWRASHSTITMTSGSLVVLFLLLSIWQPAVQVEGRRQMANSQEMIKDHLGARSQNKT-------P 63
            ||.|......:||....:|                 .:::.||:::      .:|||       .
Zfish   475 SWTAVRKKTGVTSTHNPIL-----------------TISHRQEVLE------GKNKTVGVLTVGE 516

  Fly    64 AITNNANQSSTSSADLDDGAADDDDNKADLPVNVSSKPYWRNPKKMSFLQTRPSGSLLTLNCHAL 128
            |:.:...:..||:....|        :.|:|..|:..   :.....|.::....|..|.|.|.|.
Zfish   517 ALVSGIYRCVTSNILGRD--------ELDIPFYVTDV---KEGLVASLVEEPREGGDLRLLCIAN 570

  Fly   129 GNPEPNITWYR--NGTVDWTRGY---GSLKRNRWTLT----MEDLVPGDCGNYTCKVCNSL--GC 182
            .:...:::|.|  :....|....   |.|...:::.|    :::|...|.|.|.|...:.|  ..
Zfish   571 RHLYSDLSWSRITSQITVWDEASGLDGELTEGQFSHTLHFGLKNLTARDSGTYRCSATHLLTGEH 635

  Fly   183 IRHDTQVIVSDRVNHKPILMTGPLNLTLVVNSTGSMHCKYLSDLTSKKAWIFVPCHGMTNCSNNR 247
            |..||.|.|:  |...|:|:....:.|:.|:::.::||....          ||...:|...|.|
Zfish   636 IHLDTAVEVT--VLQAPVLLGNLSDHTVNVSNSITLHCPARG----------VPQPHITWYKNQR 688

  Fly   248 SI-------IAEDKDQLDFVNVRMEQEGWYTCVESNSLGQSNSTAYLRVVRSLHVLEAGVASGSL 305
            .:       :..::..|....:.:|.:|:|||..:|..|...|:||:.|..|...|       ||
Zfish   689 KLQQVSGIMLFPEEGTLHIDRITVEDQGFYTCQATNQRGSVESSAYIWVQNSSESL-------SL 746

  Fly   306 HSTSFVYIFVFGGLIFIFMTTLFVFYAIRKMKHEKVLKQRIETVHQWTKKVIIFKPEGGGDSSGS 370
            ...:.....|...|.::.:|.|     |||:||                           .:|.:
Zfish   747 EIPTLACTCVVATLFWLLLTLL-----IRKLKH---------------------------PNSDN 779

  Fly   371 MDTMIMPVVRIQKQRTTVLQNGNEPAPFN----EYEFPLDSNWELPRSHLVLGATLGEGAFGRVV 431
            .....:|:         :|..|.||...:    :|:   .:.||.||..|.|...||.||||||:
Zfish   780 GKAEYLPI---------ILHPGEEPLVEHCDRLQYD---PAKWEFPRDRLKLEKPLGRGAFGRVM 832

  Fly   432 MAEV----NNA---IVAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQN-GPLYV 488
            .|..    |:|   .|||||:|:|.|..:..:|:.|::::..||.|||::||||.|::: |||.|
Zfish   833 QASAVGIGNSASCTTVAVKMLKDGATPSEHKALMTELKILNHIGHHINVVNLLGACTKSGGPLMV 897

  Fly   489 IVEYAPHGNLKDFLYKNRPF-------------------GR-----------------------D 511
            ||||...|||..:|...|..                   ||                       :
Zfish   898 IVEYCQFGNLSAYLKSKREVFLLNRVNKEEEGVMKEGCKGRLTSVSSRQSNASSGFSEERGEISE 962

  Fly   512 QDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFG 576
            :|.|.......|    :..:|||.::.|:||||::||||:||||||||||:|:|::.|:||.|||
Zfish   963 EDSDCLSELSDP----LLLEDLISYSFQVARGMEFLASRKCIHRDLAARNILLSNNNVVKICDFG 1023

  Fly   577 LARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAE 641
            ||||:.....|.:|.:.|||:|||||||:.:|.:.::|||||||:|||||.:.|..|||.:...|
Zfish  1024 LARDLYKDPDYVRNGDARLPLKWMAPESIFDKVFTTQSDVWSYGVLLWEIFSLGASPYPGLNMDE 1088

  Fly   642 ELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKLLQT-----KEDYLDV 701
            |....|..|.||..|...:..||.:|..||..|.:|||.||.:||.:..||||     .:||:.:
Zfish  1089 EFCRRLKHGTRMCSPQYSTPEIYSIMCACWENNPEDRPSFTTLVEILGDLLQTCVQQDGKDYIPL 1153

  Fly   702 D 702
            :
Zfish  1154 N 1154

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	112..191	CDD:299845	21/89 (24%)
		IG_like	113..191	CDD:214653	21/88 (24%)
		IG_like	205..289	CDD:214653	20/90 (22%)
		PKc_like	404..692	CDD:304357	138/337 (41%)
		STYKc	416..688	CDD:214568	134/321 (42%)
flt1	NP_001014829.3	Ig	238..321	CDD:386229
		Ig_VEGFR-1	345..416	CDD:143326
		Ig_3	426..529	CDD:372822	13/76 (17%)
		IG	558..646	CDD:214652	22/89 (25%)
		I-set	650..733	CDD:369462	20/92 (22%)
		PTKc_VEGFR	809..1138	CDD:270647	138/332 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810