DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment htl and Flt1

DIOPT Version :10

Sequence 1:NP_524394.2 Gene:htl / 42160 FlyBaseID:FBgn0010389 Length:729 Species:Drosophila melanogaster
Sequence 2:NP_062179.2 Gene:Flt1 / 54251 RGDID:2621 Length:1336 Species:Rattus norvegicus


Alignment Length:913 Identity:245/913 - (26%)
Similarity:347/913 - (38%) Gaps:318/913 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    35 VQVEGRRQMANSQEMIKDHLGARS------------------QNKTPAITNNANQSSTS-SADLD 80
            :.|:.|:|..  ||.|   .|.||                  ::..||...:|..|... |..:.
  Rat   334 ISVKHRKQQV--QETI---AGKRSHRLSMKVKAFPSPEVVWLKDGVPATEKSARYSVHGYSLIIK 393

  Fly    81 DGAADDDDN----------------KADLPVNVSSKPYWRNPKKMSFLQTRPSGSLLTLNCHALG 129
            |..|:|..:                .|.|.|||..:.|.::...:......|.||...|.|...|
  Rat   394 DVTAEDAGDYTILLGIKQSKLFRNLTATLIVNVKPQIYEKSVSSLPSPPLYPLGSRQVLTCTVYG 458

  Fly   130 NPEPNITWY-----------RNG---------TVDWTRGYGSLKRNR-------------WTLTM 161
            .|:|.|.|.           ||.         .:|.:...|    ||             ...|:
  Rat   459 IPQPTIKWLWHPCHYNHSKERNDFCFGSEESFILDSSSNIG----NRIEGITQRMMVIEGTNKTV 519

  Fly   162 EDLVPGDC---GNYTCKVCNSLGCIRHDTQVIVSD------------------------------ 193
            ..||..|.   |.|:||..|.:|.:..|.:..|:|                              
  Rat   520 STLVVADSRTPGIYSCKAFNKIGTVERDIRFYVTDVPNGFHVSLEKIPTEGEDLKLSCVVSKFLY 584

  Fly   194 -------------RVNHKPI-------LMTGPLNLTLVVNS-----TGSMHCK----YLSDLTSK 229
                         |..|..|       .....:.|.||:.:     :|:..|:    |..:...:
  Rat   585 RDITWILLRTVNNRTMHHSISKQKMATTQDYSITLNLVIKNVSLEDSGTYACRARNIYTGEEILR 649

  Fly   230 KAWIF--------------------------------VPCHGMTNCSNNRS-------IIAEDKD 255
            |..:.                                ||...:|...||..       |:.....
  Rat   650 KTEVLVRDLEAPLLLQNLSDHEVSISGSTTLDCQARGVPAPQITWFKNNHKIQQEPGIILGPGNS 714

  Fly   256 QLDFVNVRMEQEGWYTCVESNSLGQSNSTAYLRVVRSLHVLEAGVASGSLHSTSFVYIFV----F 316
            .|....|..|.||.|.|..:|..|...|:|||.|            .|:...::...|.:    .
  Rat   715 TLFIERVTEEDEGVYRCRATNQKGVVESSAYLTV------------QGTSDKSNLELITLTCTCV 767

  Fly   317 GGLIFIFMTTLFVFYAIRKMKHEKVLKQRIETVHQWTKKVIIFKPEGGGDSSGSMDTMIMPVVRI 381
            ...:|..:.|||    |||:|.                            ||..:.|..:.::. 
  Rat   768 AATLFWLLLTLF----IRKLKR----------------------------SSSEVKTDYLSIIM- 799

  Fly   382 QKQRTTVLQNGNEPAPFNEY--EFPLD-SNWELPRSHLVLGATLGEGAFGRVVMAEV-------N 436
                      ..:..|.:|.  ..|.| |.||..|..|.||.:||.||||:||.|..       .
  Rat   800 ----------DPDEVPLDEQCERLPYDASKWEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPT 854

  Fly   437 NAIVAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCS-QNGPLYVIVEYAPHGNLKD 500
            ...|||||:|||.|..:..:|:.|::::..||.|:|::||||.|: |.|||.|||||..:|||.:
  Rat   855 CRTVAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSN 919

  Fly   501 FLYKNRPF-------------------------------------------------------GR 510
            :|...|.|                                                       |.
  Rat   920 YLKSKRDFFCLNKDAALHMEPKKEKLEPDLEQDQKPRLDSVSSSESFTSSGFQEDKSVSDVEGGE 984

  Fly   511 DQDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADF 575
            |....|.||        :|.:|||.::.|:||||::|:||:||||||||||:|:|::.|:||.||
  Rat   985 DYSEISKQP--------LTMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDF 1041

  Fly   576 GLARDI-QSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMS 639
            |||||| ::.||.|:. :.|||:|||||||:.:|.|.:||||||||:|||||.:.|..|||.:..
  Rat  1042 GLARDIYKNPDYVRRG-DTRLPLKWMAPESIFDKVYSTKSDVWSYGVLLWEIFSLGGSPYPGVQM 1105

  Fly   640 AEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKLLQTK-----EDYL 699
            .|:..:.|..|.||..|...:..||.:|..|||.:..:||.|.|:||.:..|||..     :||:
  Rat  1106 DEDFCSRLKEGMRMRTPEYATPEIYQIMLDCWHKDPKERPRFAELVEKLGDLLQANVQQDGKDYI 1170

  Fly   700 DVD 702
            .::
  Rat  1171 PLN 1173

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
htlNP_524394.2 Ig 101..191 CDD:472250 28/125 (22%)
Ig strand B 121..125 CDD:409353 1/3 (33%)
Ig strand C 134..138 CDD:409353 1/3 (33%)
Ig strand E 157..161 CDD:409353 0/3 (0%)
Ig strand F 171..176 CDD:409353 2/4 (50%)
Ig strand G 184..187 CDD:409353 0/2 (0%)
Ig 200..289 CDD:472250 27/143 (19%)
Ig strand B 216..220 CDD:409353 1/3 (33%)
Ig strand C 229..233 CDD:409353 1/3 (33%)
Ig strand E 255..259 CDD:409353 1/3 (33%)
Ig strand F 269..274 CDD:409353 2/4 (50%)
Ig strand G 282..285 CDD:409353 1/2 (50%)
Protein Kinases, catalytic domain 404..692 CDD:473864 143/352 (41%)
Flt1NP_062179.2 IG_like 143..219 CDD:214653
Ig 231..330 CDD:472250
Ig strand B 248..252 CDD:409353
Ig strand C 263..267 CDD:409353
Ig strand E 294..298 CDD:409353
Ig strand F 308..313 CDD:409353
Ig strand G 321..324 CDD:409353
Ig 333..424 CDD:472250 19/94 (20%)
Ig strand B 353..357 CDD:409353 0/3 (0%)
Ig strand C 366..370 CDD:409353 0/3 (0%)
Ig strand E 388..392 CDD:409353 1/3 (33%)
Ig strand F 402..407 CDD:409353 0/4 (0%)
Ig strand G 417..420 CDD:409353 0/2 (0%)
Ig 447..552 CDD:472250 26/108 (24%)
Ig strand B 450..454 CDD:409353 1/3 (33%)
Ig strand C 463..467 CDD:409353 1/3 (33%)
Ig strand E 515..519 CDD:409353 0/3 (0%)
Ig strand F 532..537 CDD:409353 2/4 (50%)
Ig strand G 545..548 CDD:409353 0/2 (0%)
IG_like 568..640 CDD:214653 8/71 (11%)
Ig strand B 573..577 CDD:409353 0/3 (0%)
Ig strand C 586..594 CDD:409353 0/7 (0%)
Ig strand E 619..623 CDD:409353 2/3 (67%)
Ig strand F 633..638 CDD:409353 1/4 (25%)
I-set 661..748 CDD:400151 19/86 (22%)
Ig strand B 679..682 CDD:409353 0/2 (0%)
Ig strand C 691..695 CDD:409353 1/3 (33%)
Ig strand E 714..718 CDD:409353 1/3 (33%)
Ig strand F 728..733 CDD:409353 2/4 (50%)
Protein Kinases, catalytic domain 819..1157 CDD:473864 140/346 (40%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.