DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment htl and FGFRL1

DIOPT Version :9

Sequence 1:	NP_524394.2	Gene:	htl / 42160	FlyBaseID:	FBgn0010389	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	XP_024309860.1	Gene:	FGFRL1 / 53834	HGNCID:	3693	Length:	527	Species:	Homo sapiens

Alignment Length:	298	Identity:	84/298 - (28%)
Similarity:	130/298 - (43%)	Gaps:	33/298 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 GARSQNKTPAITNNANQSSTS-SADLDDGAADDDDNKADLPVNVS-SKPYWRNPKKM-SFLQTRP 116
            |:.|.|.|..:.::.:....| ..|...|..:|       |.:.. ::|.:..|.|| ..:..||
Human   129 GSLSVNYTLVVLDDISPGKESLGPDSSSGGQED-------PASQQWARPRFTQPSKMRRRVIARP 186

  Fly   117 SGSLLTLNCHALGNPEPNITWYRNGTVDWTRGYGSLKRNRWTLTMEDLVPGDCGNYTCKVCNSLG 181
            .||.:.|.|.|.|:|.|:|||.::............::.:|||::::|.|.|.|.|||:|.|..|
Human   187 VGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAG 251

  Fly   182 CIRHDTQVIVSDRVNHKPILM-TGPLNLTLVVNSTGSMHCKYLSDLTSKKAWIFVPCHGMTNCSN 245
            .|....:|.|..|...||:|. |.|:|.|:....|.|..||..||:.....|:....:|.....|
Human   252 AINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHN 316

  Fly   246 NRSIIAEDK------------------DQLDFVNVRMEQEGWYTCVESNSLGQSNSTAYLRVVRS 292
            :...:...|                  ::|.....|.:..|.|.|:.:|::|.|..:|:|.|:..
Human   317 STIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPD 381

  Fly   293 LHVLEAGVASGSLHSTSFVYIFVFG---GLIFIFMTTL 327
            .......|||.| .:||..:..|.|   |.:||..|.|
Human   382 PKPPGPPVASSS-SATSLPWPVVIGIPAGAVFILGTLL 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	112..191	CDD:299845	28/78 (36%)
		IG_like	113..191	CDD:214653	28/77 (36%)
		IG_like	205..289	CDD:214653	23/101 (23%)
		PKc_like	404..692	CDD:304357
		STYKc	416..688	CDD:214568
FGFRL1	XP_024309860.1	I-set	56..139	CDD:254352	4/9 (44%)
		Ig2_FGFRL1-like	180..261	CDD:143264	28/80 (35%)
		Ig	284..378	CDD:325142	20/93 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810