DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment htl and PDGFRB

DIOPT Version :9

Sequence 1:	NP_524394.2	Gene:	htl / 42160	FlyBaseID:	FBgn0010389	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_002600.1	Gene:	PDGFRB / 5159	HGNCID:	8804	Length:	1106	Species:	Homo sapiens

Alignment Length:	799	Identity:	218/799 - (27%)
Similarity:	335/799 - (41%)	Gaps:	213/799 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 SSTSSADLDDGAADDDDNKADLPVNVSSKPYWRNPKKMSFLQTRPSGSLLTLNCHALGNPEPNIT 136
            |.|.:.::.:...|..|.|| :.:.|....|.|...::..||........||.......|.|.:.
Human   286 SGTYTCNVTESVNDHQDEKA-INITVVESGYVRLLGEVGTLQFAELHRSRTLQVVFEAYPPPTVL 349

  Fly   137 WYR-NGTV-DWTRGYGSLK-RN----RWT--LTMEDLVPGDCGNYTCKVCNSLGCIRHDTQVIVS 192
            |:: |.|: |.:.|..:|. ||    |:.  ||:..:...:.|:||.:      ....|.:|.:|
Human   350 WFKDNRTLGDSSAGEIALSTRNVSETRYVSELTLVRVKVAEAGHYTMR------AFHEDAEVQLS 408

  Fly   193 DRVN-HKPILMTGPLNLTLVVNSTGSMHCKYLSDLTSKKAWIFVPCHGMTNCS--------NNRS 248
            .::. :.|:.:   |.|:.....:|....:.......:...|:..|..:..|.        .|.|
Human   409 FQLQINVPVRV---LELSESHPDSGEQTVRCRGRGMPQPNIIWSACRDLKRCPRELPPTLLGNSS 470

  Fly   249 IIAEDKDQLDFVNVRMEQEGWY-----------------TCVESNSLGQSNSTAYLRVVRSLHVL 296
               |::.||:......|:|..:                 .|...|::||  .|..:.||.
Human   471 ---EEESQLETNVTYWEEEQEFEVVSTLRLQHVDRPLSVRCTLRNAVGQ--DTQEVIVVP----- 525

  Fly   297 EAGVASGSLHSTSFVYIFVFGGLIFIFMTTLFVFYAIRKMKHEKVLKQRIETVHQWTKKVIIFKP 361
                     ||..|..:.:...|..:.:|.:.:...|  |..:|  |.|.|.  :|  |||
Human   526 ---------HSLPFKVVVISAILALVVLTIISLIILI--MLWQK--KPRYEI--RW--KVI---- 569

  Fly   362 EGGGDSSGSMDTMIMPVVRIQKQRTTVLQNGNEPAPFNEYEFPLDSNWELPRSHLVLGATLGEGA 426
                                    .:|..:|:|....:..:.|.||.|||||..||||.|||.||
Human   570 ------------------------ESVSSDGHEYIYVDPMQLPYDSTWELPRDQLVLGRTLGSGA 610

  Fly   427 FGRVVMAEVNNAI-------VAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQNG 484
            ||:||.|..:...       |||||:|......:..:|:.|:::|..:|.|:|::||||.|::.|
Human   611 FGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGG 675

  Fly   485 PLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQPP----------------------------- 520
            |:|:|.||..:|:|.|:|::|:........|..:||
Human   676 PIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGY 740

  Fly   521 ---------------------------------------PSPP-----------AHVITEKDLIK 535
                                                   ||.|           :.|::..||:.
Human   741 MDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVG 805

  Fly   536 FAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWM 600
            |::|:|.||::|||:.|:||||||||||:.:..::||.||||||||.....|....:..||:|||
Human   806 FSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWM 870

  Fly   601 APESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYI 665
            ||||:....|.:.|||||:|||||||.|.|..|||.:...|:.|..:..|.||.:||..|..||.
Human   871 APESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYE 935

  Fly   666 LMRQCWHFNADDRPPFTEIVEYMDKLL---------QTKEDYLDVD-------------IANLDT 708
            :|::||....:.||||:::|..:::||         |..|::|..|             ...|.:
Human   936 IMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQVDEEFLRSDHPAILRSQARLPGFHGLRS 1000

  Fly   709 PPSTSD-----EEEDETDN 722
            |..||.     .:.:|.||
Human  1001 PLDTSSVLYTAVQPNEGDN 1019

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	112..191	CDD:299845	22/87 (25%)
		IG_like	113..191	CDD:214653	21/86 (24%)
		IG_like	205..289	CDD:214653	18/108 (17%)
		PKc_like	404..692	CDD:304357	134/373 (36%)
		STYKc	416..688	CDD:214568	126/357 (35%)
PDGFRB	NP_002600.1	ig	37..114	CDD:278476
		IG	40..110	CDD:214652
		IG_like	222..310	CDD:214653	6/24 (25%)
		Ig1_PDGFR-alphabeta	228..312	CDD:143269	7/26 (27%)
		Ig4_PDGFR-alpha	314..415	CDD:143267	25/106 (24%)
		Ig	425..523	CDD:299845	16/102 (16%)
		PTKc_PDGFR_beta	562..953	CDD:133238	141/422 (33%)
		Pkinase_Tyr	600..953	CDD:285015	125/352 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1019..1106		1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810