Protein Alignment htl and PDGFRA

DIOPT Version :9

• Sequence 1: NP_524394.2
• Gene: htl / 42160
• FlyBaseID: FBgn0010389
• Length: 729
• Species: Drosophila melanogaster
• Sequence 2: NP_001334757.1
• Gene: PDGFRA / 5156
• HGNCID: 8803
• Length: 1114
• Species: Homo sapiens
• Alignment Length: 846
• Identity: 218/846 - (25%)
• Similarity: 324/846 - (38%)
• Gaps: 286/846 - (33%)

  Fly   108 KMSFLQT-RPSGSLLTLNCHALGNPEPNITWYRNGTVDWTRGYG----------SLKRNRWTLTM 161
            :|..|:| ..||..:.:.|....|...::.|...|.|   :|.|          |:|. .:|||:
Human   242 EMEALKTVYKSGETIVVTCAVFNNEVVDLQWTYPGEV---KGKGITMLEEIKVPSIKL-VYTLTV 302

  Fly   162 EDLVPGDCGNYTCKVCNSLGCIRHDTQVIVSDRVNHKPILMTGPL-------------------- 206
            .:....|.|:|.|....:...::...:|.:|  |:.|..:...|.
Human   303 PEATVKDSGDYECAARQATREVKEMKKVTIS--VHEKGFIEIKPTFSQLEAVNLHEVKHFVVEVR 365

  Fly   207 ------------NLTLVVNST-------GSMHCKYLSDLTSKKAWIFVPCHGMTNCSNNRSIIAE 252
                        ||||:.|.|       .....:|.|.|...:|        ....|.:.:|:|:
Human   366 AYPPPRISWLKNNLTLIENLTEITTDVEKIQEIRYRSKLKLIRA--------KEEDSGHYTIVAQ 422

  Fly   253 DKDQ----------------LDFVN----------VRMEQEG-------WYTCVESNSLGQSNST 284
            ::|.                ||.|:          ||...||       |..|.:........|.
Human   423 NEDAVKSYTFELLTQVPSSILDLVDDHHGSTGGQTVRCTAEGTPLPDIEWMICKDIKKCNNETSW 487

  Fly   285 AYL-----RVVRSLH-----VLEAGVASGSLHSTSFVYIF---VFGG------------------ 318
            ..|     .::..:|     .:|..|....:..|..|...   :.|.
Human   488 TILANNVSNIITEIHSRDRSTVEGRVTFAKVEETIAVRCLAKNLLGAENRELKLVAPTLRSELTV 552

  Fly   319 ------LIFIFMTTLFVFYAIRKMKHEKVLKQR-IETVHQWTKKVIIFKPEGGGDSSGSMDTMIM 376
                  |:.|.:.:|.|...|.|.|....::.| ||::          .|:|
Human   553 AAAVLVLLVIVIISLIVLVVIWKQKPRYEIRWRVIESI----------SPDG------------- 594

  Fly   377 PVVRIQKQRTTVLQNGNEPAPFNEY------EFPLDSNWELPRSHLVLGATLGEGAFGRVVMAEV 435
                                  :||      :.|.||.||.||..||||..||.||||:||....
Human   595 ----------------------HEYIYVDPMQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTA 637

  Fly   436 NNAI-------VAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYA 493
            ....       |||||:|......:..:|:.|:::|..:|.|:||:||||.|:::||:|:|.||.
Human   638 YGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYC 702

  Fly   494 PHGNLKDFLYKNRP----------------FGRD-----------------------QDRDSSQP 519
            .:|:|.::|:|||.                ||.:                       :..|::|.
Human   703 FYGDLVNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQADTTQY 767

  Fly   520 PP------------------SPPAHV---------------------ITEKDLIKFAHQIARGMD 545
            .|                  ..||..                     :|..||:.|.:|:||||:
Human   768 VPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGME 832

  Fly   546 YLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFY 610
            :|||:.|:||||||||||::...::||.||||||||.....|....:..||:|||||||:.:..|
Human   833 FLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLY 897

  Fly   611 DSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNA 675
            .:.|||||||||||||.:.|..|||.:|.....|..:.||.||.||...:..:|.:|.:||:...
Human   898 TTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEP 962

  Fly   676 DDRPPFTEIVEYMDKLL--QTKEDY--LDVDIANLDTPPST-----SDEE------EDETDNLQK 725
            :.||.|..:.|.::.||  |.|:.|  :.:|....|.|...     ||..      ::|.|.|:.
Human   963 EKRPSFYHLSEIVENLLPGQYKKSYEKIHLDFLKSDHPAVARMRVDSDNAYIGVTYKNEEDKLKD 1027

  Fly   726 W 726
            |
Human  1028 W 1028

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	112..191	CDD:299845	21/89 (24%)
		IG_like	113..191	CDD:214653	20/88 (23%)
		IG_like	205..289	CDD:214653	26/160 (16%)
		PKc_like	404..692	CDD:304357	133/372 (36%)
		STYKc	416..688	CDD:214568	126/356 (35%)
PDGFRA	NP_001334757.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810