DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment htl and Styk1

DIOPT Version :9

Sequence 1:	NP_524394.2	Gene:	htl / 42160	FlyBaseID:	FBgn0010389	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	XP_038964794.1	Gene:	Styk1 / 500340	RGDID:	1564211	Length:	436	Species:	Rattus norvegicus

Alignment Length:	460	Identity:	109/460 - (23%)
Similarity:	205/460 - (44%)	Gaps:	55/460 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   278 LGQSNSTAYLRVVRSLHVLEAGVASGSLHSTSFVYIFVFGGLIFIFMTTLFVFYAIRKMKHEKVL 342
            ||:.|...:|..:...:.    |.....:....|...:.|..:.:....|::|          :.
  Rat    11 LGRGNCVRFLLFLFMAYT----VVQEKQYEVIIVPALLVGSFLILLAIILWLF----------IR 61

  Fly   343 KQRIETVH---QWTKKVIIFKPEGGGDSS---GSMDTMIMPVVRIQKQRTTVLQNGNEPAPFNEY 401
            .||.:..|   :.|..|    |...|.|.   |..:.:.:|:     :.|:|       ..|...
  Rat    62 GQRSQRQHPGPRGTTSV----PASRGRSQEAVGHGEKVFVPL-----KETSV-------ESFLRA 110

  Fly   402 EFPLDSNWELPRSHLV-LGATLGEGAFGRVVMAEV------NNAIVAVKMVKEGHTDDDIASLVR 459
            ..|..:..::||..|: :...:..|:.|.:..|::      |...|.:|.::......::...:.
  Rat   111 VTPSLAKLQVPREQLLEVLEQIHSGSCGTLYHAKMTTMEHPNPKSVVLKALEGSVGLQEVQDFIG 175

  Fly   460 EMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRD-QDRDSSQPPPSP 523
            .::..:.:|:|.|::.|.|||::..|||:::|....|:|.:||:..|   || ...|..
  Rat   176 RIQFYQYLGKHKNLVQLEGCCTERLPLYMMLEDVVPGDLLNFLWTCR---RDVMTMDGL------ 231

  Fly   524 PAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYR 588
             .:.:|||.:.....|:...:::|..:...|.|:||||:|:..|...|:...|||.::.:.....
  Rat   232 -LYDLTEKQIYHIGKQVLLALEFLQEKHLFHGDVAARNILIQSDLTPKLCHLGLAYEVHTHGAIS 295

  Fly   589 KNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRM 653
            ...:..:|:||:|||.|..:....:.||||:||||:|::|.|..|||.: ....:..||...:.|
  Rat   296 SARSSTIPLKWLAPERLLLRPASIRGDVWSFGILLYEMVTLGAPPYPEV-PPTSILQYLQRKKIM 359

  Fly   654 EKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKLLQTKEDYLDVDIANLDTPPSTSDEEED 718
            ::|:.|:..:|.:|:.||.::.|.||...|:...::...:|..|...:.:..|..|...:|....
  Rat   360 KRPSSCTHAMYNIMKYCWRWSEDSRPLPGELRLRLEAASRTANDKAVLQVPELVVPDLYADVAGI 424

  Fly   719 ETDNL 723
            .|::|
  Rat   425 STESL 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	112..191	CDD:299845
		IG_like	113..191	CDD:214653
		IG_like	205..289	CDD:214653	4/10 (40%)
		PKc_like	404..692	CDD:304357	80/295 (27%)
		STYKc	416..688	CDD:214568	77/279 (28%)
Styk1	XP_038964794.1	PKc_like	130..395	CDD:419665	76/275 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810