DRSC/TRiP Functional Genomics Resources

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Protein Alignment htl and ROR2

DIOPT Version :10

Sequence 1:NP_524394.2 Gene:htl / 42160 FlyBaseID:FBgn0010389 Length:729 Species:Drosophila melanogaster
Sequence 2:NP_004551.2 Gene:ROR2 / 4920 HGNCID:10257 Length:943 Species:Homo sapiens


Alignment Length:779 Identity:183/779 - (23%)
Similarity:278/779 - (35%) Gaps:247/779 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    78 DLDDGAADDDDNKADLPVNVSSKPYWRNPKKMSFLQ-----TRPSGSLLTLNCHALGNPEPNITW 137
            |.:|.....|.....:|   :.|.|:.|     ||:     |...|....|:|...|||.||:.|
Human    39 DPNDPLGPLDGQDGPIP---TLKGYFLN-----FLEPVNNITIVQGQTAILHCKVAGNPPPNVRW 95

  Fly   138 YRNG--TVDWTR-------GYGSLKRNRWTLTMEDLVPGDCGNYTCKVCNSLGCIRHDTQVIVSD 193
            .:|.  .|...|       .|||      .|.::||...|.|.|.|...|.:..|.....:.|..
Human    96 LKNDAPVVQEPRRIIIRKTEYGS------RLRIQDLDTTDTGYYQCVATNGMKTITATGVLFVRL 154

  Fly   194 RVNHKP-----------------------------------ILMTGPLN------LTLVVNSTGS 217
            ...|.|                                   :.|.|.:.      .|::..||  
Human   155 GPTHSPNHNFQDDYHEDGFCQPYRGIACARFIGNRTIYVDSLQMQGEIENRITAAFTMIGTST-- 217

  Fly   218 MHCKYLSDLTSKKA------WIFVPCHGMTNCSNNRSIIAEDKDQLDFVNVRMEQEGWYTCVESN 276
                :|||..|:.|      ::|..|...:.....|.:..::.:.|:....|.|    ||...||
Human   218 ----HLSDQCSQFAIPSFCHFVFPLCDARSRTPKPRELCRDECEVLESDLCRQE----YTIARSN 274

  Fly   277 SL-------------------------------------------------GQSNST-------- 284
            .|                                                 |.:::|        
Human   275 PLILMRLQLPKCEALPMPESPDAANCMRIGIPAERLGRYHQCYNGSGMDYRGTASTTKSGHQCQP 339

  Fly   285 -----------------------AYLR-------------VVRSLHVLEAGVASGSLHSTS---F 310
                                   ||.|             ..:::.:....|.|.|...:|   .
Human   340 WALQHPHSHHLSSTDFPELGGGHAYCRNPGGQMEGPWCFTQNKNVRMELCDVPSCSPRDSSKMGI 404

  Fly   311 VYIFVFGGLIFIFMTTLFVFYAI--RKMKHEKVLKQRIETVHQWTKKVIIFKPEGGGDSSGSMDT 373
            :||.|....|.:.:..||....:  .|.|......||.:.:                 :|.|.| 
Human   405 LYILVPSIAIPLVIACLFFLVCMCRNKQKASASTPQRRQLM-----------------ASPSQD- 451

  Fly   374 MIMPVVRIQKQRTTVLQNGNEPAPFNEYEFPLDSNWELPRSHLVLGATLGEGAFGRVVMAEV--- 435
            |.||::...||....                     |:..|.:.....|||..||:|....:   
Human   452 MEMPLINQHKQAKLK---------------------EISLSAVRFMEELGEDRFGKVYKGHLFGP 495

  Fly   436 ----NNAIVAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPHG 496
                ....||:|.:|: ..:..:....|...:::...:|.|::.|||..:::.||.:|..|..||
Human   496 APGEQTQAVAIKTLKD-KAEGPLREEFRHEAMLRARLQHPNVVCLLGVVTKDQPLSMIFSYCSHG 559

  Fly   497 NLKDFLYKNRPF----GRDQDR--DSSQPPPSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHR 555
            :|.:||....|.    ..|.||  .|:..||          |.:....|||.||:||:|...:|:
Human   560 DLHEFLVMRSPHSDVGSTDDDRTVKSALEPP----------DFVHLVAQIAAGMEYLSSHHVVHK 614

  Fly   556 DLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYG 620
            |||.|||||.|...:||:|.||.|::.:.|||:...|..|||:|||||::....:...||:||||
Human   615 DLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLGNSLLPIRWMAPEAIMYGKFSIDSDIWSYG 679

  Fly   621 ILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEI 684
            ::|||:.:||.||| ...|.:::...:.:.|.:..|..|...:|.||.:||:.....||.|.:|
Human   680 VVLWEVFSYGLQPY-CGYSNQDVVEMIRNRQVLPCPDDCPAWVYALMIECWNEFPSRRPRFKDI 742

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
htlNP_524394.2 Ig 101..191 CDD:472250 29/103 (28%)
Ig strand B 121..125 CDD:409353 1/3 (33%)
Ig strand C 134..138 CDD:409353 1/3 (33%)
Ig strand E 157..161 CDD:409353 1/3 (33%)
Ig strand F 171..176 CDD:409353 2/4 (50%)
Ig strand G 184..187 CDD:409353 0/2 (0%)
Ig 200..289 CDD:472250 26/193 (13%)
Ig strand B 216..220 CDD:409353 0/3 (0%)
Ig strand C 229..233 CDD:409353 1/9 (11%)
Ig strand E 255..259 CDD:409353 1/3 (33%)
Ig strand F 269..274 CDD:409353 2/4 (50%)
Ig strand G 282..285 CDD:409353 1/33 (3%)
Protein Kinases, catalytic domain 404..692 CDD:473864 98/294 (33%)
ROR2NP_004551.2 I-set 64..152 CDD:400151 27/93 (29%)
Ig strand B 79..83 CDD:409353 1/3 (33%)
Ig strand C 92..96 CDD:409353 1/3 (33%)
Ig strand E 118..122 CDD:409353 2/9 (22%)
Ig strand F 132..137 CDD:409353 2/4 (50%)
Ig strand G 145..148 CDD:409353 0/2 (0%)
CRD_TK_ROR2 170..309 CDD:143577 21/148 (14%)
KR 314..395 CDD:214527 7/80 (9%)
PTKc_Ror2 466..749 CDD:270673 98/310 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 757..796
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 850..931
Blue background indicates that the domain is not in the aligned region.

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