DRSC/TRiP Functional Genomics Resources

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Protein Alignment htl and NTRK2

DIOPT Version :10

Sequence 1:NP_524394.2 Gene:htl / 42160 FlyBaseID:FBgn0010389 Length:729 Species:Drosophila melanogaster
Sequence 2:NP_006171.2 Gene:NTRK2 / 4915 HGNCID:8032 Length:838 Species:Homo sapiens


Alignment Length:676 Identity:176/676 - (26%)
Similarity:290/676 - (42%) Gaps:134/676 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly   114 TRPSGSLLTLNCHALGNPEPNITWYRNGTVDWTRGYGSLKRNRWTLTMEDLVPGDCG-NYTCKVC 177
            |...|..:||:|...|:|.||:.|.....|  ::........:.:|.:.::...|.| ..:|...
Human   207 TVEEGKSITLSCSVAGDPVPNMYWDVGNLV--SKHMNETSHTQGSLRITNISSDDSGKQISCVAE 269

  Fly   178 NSLGCIRHDTQVIVSDRVNHKPIL--MTGP-------LNLTLVVNSTGSMHCKYLSDLTSKKAWI 233
            |.:|    :.|..|:..|:..|.:  :..|       :..|:..|...::...|...:.::..:|
Human   270 NLVG----EDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYI 330

  Fly   234 FVPCHGMTNCSNNRSIIAEDKDQLDFVNVRMEQEGWYTCVESNSLGQSN---------------- 282
            ....| :||.:.....:     |||  |......|.||.:..|..|:..                
Human   331 CTKIH-VTNHTEYHGCL-----QLD--NPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDG 387

  Fly   283 -STAYLRVV----------------RSLHVLEAGVA--SGSLHSTSFVYIFVFGGLIFIFMTTLF 328
             :..|..|:                ||..:....|.  :|..|.:.:..:.:...:.|..:..||
Human   388 ANPNYPDVIYEDYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLF 452

  Fly   329 VFYAIRKMKHEKV-LKQRIETVHQWTKKVIIFKPEGGG--------------------------D 366
            :   ::..:|.|. :|.     ..|.....:...:|.|                          .
Human   453 L---LKLARHSKFGMKD-----FSWFGFGKVKSRQGVGPASVISNDDDSASPLHHISNGSNTPSS 509

  Fly   367 SSGSMDTMIMPVVRIQKQRTTVLQNGN---------EPAPFNEYEFPLDSNWELPRSHLVLGATL 422
            |.|..|.:|:.:.:|     .|::|..         :|..|.::         :.|.::||...|
Human   510 SEGGPDAVIIGMTKI-----PVIENPQYFGITNSQLKPDTFVQH---------IKRHNIVLKREL 560

  Fly   423 GEGAFGRVVMAEVNN-------AIVAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCC 480
            ||||||:|.:||..|       .:||||.:|:. :|:......||.|::..: :|.:|:...|.|
Human   561 GEGAFGKVFLAECYNLCPEQDKILVAVKTLKDA-SDNARKDFHREAELLTNL-QHEHIVKFYGVC 623

  Fly   481 SQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMD 545
            .:..||.::.||..||:|..||   |..|.|....:...||:.    :|:..::..|.|||.||.
Human   624 VEGDPLIMVFEYMKHGDLNKFL---RAHGPDAVLMAEGNPPTE----LTQSQMLHIAQQIAAGMV 681

  Fly   546 YLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFY 610
            ||||:..:|||||.||.||.::.::||.|||::||:.||||||...:..|||:||.|||:..:.:
Human   682 YLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKF 746

  Fly   611 DSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNA 675
            .::|||||.|::||||.|||:||:.. :|..|:...:..|:.:::|..|...:|.||..||....
Human   747 TTESDVWSLGVVLWEIFTYGKQPWYQ-LSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREP 810

  Fly   676 DDRPPFTEIVEYMDKLLQTKEDYLDV 701
            ..|.....|...:..|.:....|||:
Human   811 HMRKNIKGIHTLLQNLAKASPVYLDI 836

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
htlNP_524394.2 Ig 101..191 CDD:472250 18/77 (23%)
Ig strand B 121..125 CDD:409353 2/3 (67%)
Ig strand C 134..138 CDD:409353 1/3 (33%)
Ig strand E 157..161 CDD:409353 1/3 (33%)
Ig strand F 171..176 CDD:409353 1/4 (25%)
Ig strand G 184..187 CDD:409353 0/2 (0%)
Ig 200..289 CDD:472250 18/114 (16%)
Ig strand B 216..220 CDD:409353 0/3 (0%)
Ig strand C 229..233 CDD:409353 0/3 (0%)
Ig strand E 255..259 CDD:409353 2/3 (67%)
Ig strand F 269..274 CDD:409353 2/4 (50%)
Ig strand G 282..285 CDD:409353 0/19 (0%)
Protein Kinases, catalytic domain 404..692 CDD:473864 109/294 (37%)
NTRK2NP_006171.2 LRR_8 92..150 CDD:404697
LRR 1 92..113
LRR 2 116..137
LRRCT_2 151..195 CDD:465313
Ig 205..283 CDD:472250 19/81 (23%)
Ig strand B 214..218 CDD:409353 2/3 (67%)
Ig strand C 227..230 CDD:409353 1/2 (50%)
Ig strand E 245..252 CDD:409353 1/6 (17%)
Ig strand F 262..268 CDD:409353 1/5 (20%)
Ig strand G 276..279 CDD:409353 1/2 (50%)
IgI_TrkB_d5 286..379 CDD:409441 18/100 (18%)
Ig strand A 286..294 CDD:409441 1/7 (14%)
Ig strand A' 295..298 CDD:409441 1/2 (50%)
Ig strand B 301..309 CDD:409441 1/7 (14%)
Ig strand C 312..319 CDD:409441 0/6 (0%)
Ig strand C' 322..325 CDD:409441 0/2 (0%)
Ig strand D 330..335 CDD:409441 1/4 (25%)
Ig strand E 341..349 CDD:409441 1/12 (8%)
Ig strand F 357..365 CDD:409441 3/7 (43%)
Ig strand G 368..376 CDD:409441 1/7 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 491..514 2/22 (9%)
PTKc_TrkB 548..835 CDD:270675 111/305 (36%)
Blue background indicates that the domain is not in the aligned region.

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