Protein Alignment htl and LOC4578387

DIOPT Version :10

• Sequence 1: NP_524394.2
• Gene: htl / 42160
• FlyBaseID: FBgn0010389
• Length: 729
• Species: Drosophila melanogaster
• Sequence 2: XP_061510796.1
• Gene: LOC4578387 / 4578387
• VectorBaseID: AGAMI1_010804
• Length: 1482
• Species: Anopheles gambiae
• Alignment Length: 755
• Identity: 188/755 - (24%)
• Similarity: 311/755 - (41%)
• Gaps: 201/755 - (26%)

  Fly    14 ITMTSGSLVVLFL---LLSIWQPAVQVEGRRQMANSQEMIKDHLGARSQNKTPAITNNANQSSTS 75
            :.||:.:..:.||   |.::|..:.:|.|....|.:              ..|..||...:..|:
Mosquito   662 LEMTAENGYIWFLPIWLSNVWNFSSEVPGGENGATA--------------VPPTSTNRTTRGCTN 712

  Fly    76 SADLDDGAADDDDNKADLPVNVSSKPYWRNPKKMSFLQTRPSGSLLTLNCHALGNPEPNITWYRN 140
            |..|         ...:...::|..||            ....|:|.:|              |:
Mosquito   713 SELL---------RAMNGHFSLSHAPY------------ADDDSILDVN--------------RS 742

  Fly   141 GTV-DWTRGYGSLKRNRWTLTMEDLVPGDCGNYTCKVCNSLGCIRHD---TQVIVSDRVNHKPIL 201
            .|| ||.:.|..      :|:..:.:..|...:.           :|   ...:..||     :|
Mosquito   743 ATVRDWKQAYNV------SLSEYNYMASDYAGFA-----------YDAVWVYALAFDR-----LL 785

  Fly   202 MTGPLNLTLVVNSTGSMHCKYLSDL----TSKKAWIFV---PCHGMT-----NCSNNRSIIAEDK 254
            ...|               .|:|||    |:|:....:   ...|:|     |.:.:|..|.
Mosquito   786 REDP---------------SYISDLHSRHTTKRLMELIRETDFQGVTGRIKFNEAGSRYTIV--- 832

  Fly   255 DQLDFVNVRMEQEGWYTCVESNS----LGQS---NSTAYLRVVRSLHVLEAGVASGSLHSTSFVY 312
            :.|.|||......|.:|...|..    ||..   |.:|.:.:.|..|:.:.|....:|.|    :
Mosquito   833 NVLQFVNGTANIVGHFTPNISEPDYKLLGGDLVLNESAIVWMTRDGHIPDDGTPVCALES----F 893

  Fly   313 IFVFG------GLIFIFMTTL----------FVFYAIRKMKHEKVLKQRIETVHQWTKKVIIFKP 361
            :.:||      .:|.|.|.::          |:|:.:|       ..::::|..::.:|:
Mosquito   894 VRIFGISCDEVTMIVISMVSIISILILSVASFLFWKVR-------YDRKMQTSAKYLQKL----- 946

  Fly   362 EGGGD----SSGSMDTMIMPVVRIQKQRTTVLQNGNEPAPFNEYEFPLDSNWELPRSHLVLGATL 422
              |.|    :||.::|:                                ..||:|:..:|:...|
Mosquito   947 --GIDLLSQTSGPVNTL--------------------------------DKWEIPKDRVVINRRL 977

  Fly   423 GEGAFGRVVMAEVNN-----AIVAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQ 482
            ||||||.|...|...     ..||||.:|.|.|.:|....:.|.|.||... |.||:.|||.|.|
Mosquito   978 GEGAFGTVYGGEAQIGDEGWTAVAVKTLKVGSTTEDKVDFLSEAEAMKRFD-HNNIVRLLGVCLQ 1041

  Fly   483 NGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMDYL 547
            :.|:|.::|:..:|:||.:|...|.....:..:.|.         |:.|.|...|..::|.:.||
Mosquito  1042 SEPVYTVMEFMLYGDLKTYLLARRHLVNSKQSEDSD---------ISNKRLTMMALDVSRALSYL 1097

  Fly   548 ASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDS 612
            |.::.:|||:|.||.:|:...|:|:.|||:||.....||||.|..|.||::|||||||....:..
Mosquito  1098 AEQKYVHRDVACRNCMVNAQRVVKLGDFGMARPTFENDYYRFNRRGMLPVRWMAPESLGLGIFTP 1162

  Fly   613 KSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADD 677
            .|||||||:||:||:|:|..|:..:.: .::..:|.:|..:..||.....:..||:.||:.:...
Mosquito  1163 ASDVWSYGVLLYEIITFGSFPFQGLTN-NQVLEHLKNGNTITIPAGVKPQLEGLMKACWNQDYKK 1226

  Fly   678 RPPFTEIVEYMDKLLQTKEDYLDVDIANLDTPPSTSDEEE 717
            ||..:|:.|::....:.....|||.:|:::...:.||:.|
Mosquito  1227 RPSASEVSEFISNYPRLLNPCLDVPLASVEMVDTGSDQFE 1266

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	101..191	CDD:472250	14/93 (15%)
		Ig strand B	121..125	CDD:409353	1/3 (33%)
		Ig strand C	134..138	CDD:409353	0/3 (0%)
		Ig strand E	157..161	CDD:409353	1/3 (33%)
		Ig strand F	171..176	CDD:409353	0/4 (0%)
		Ig strand G	184..187	CDD:409353	1/5 (20%)
		Ig	200..289	CDD:472250	24/107 (22%)
		Ig strand B	216..220	CDD:409353	0/3 (0%)
		Ig strand C	229..233	CDD:409353	1/3 (33%)
		Ig strand E	255..259	CDD:409353	1/3 (33%)
		Ig strand F	269..274	CDD:409353	1/4 (25%)
		Ig strand G	282..285	CDD:409353	1/2 (50%)
		Protein Kinases, catalytic domain	404..692	CDD:473864	105/292 (36%)
LOC4578387	XP_061510796.1	None