Protein Alignment htl and drl

DIOPT Version :9

• Sequence 1: NP_524394.2
• Gene: htl / 42160
• FlyBaseID: FBgn0010389
• Length: 729
• Species: Drosophila melanogaster
• Sequence 2: NP_001260566.1
• Gene: drl / 44355
• FlyBaseID: FBgn0015380
• Length: 645
• Species: Drosophila melanogaster
• Alignment Length: 670
• Identity: 157/670 - (23%)
• Similarity: 257/670 - (38%)
• Gaps: 186/670 - (27%)

  Fly   118 GSLLT------------LNCH---ALGNPEPNITWYRNGTVDWTRGYGSLKRNRWTLTMEDLVPG 167
            |.|||            ||.|   .|......:.:.|.|.:           |.:.|.....||.
  Fly     9 GLLLTLIASGQAHLNIFLNLHEVLRLIGVSAELYYVREGAI-----------NDYALNFAVPVPA 62

  Fly   168 DCGNYTC--------KVCNSLGCIRHDTQVIVSDRVNHKPILMTGPLNLTLVVNSTGSMHCKYLS 224
            :..:.|.        .:..|:.....||:|:      .:||     ||::.:            .
  Fly    63 NISDVTFTWQSLVDHPLPYSINIATSDTEVL------PRPI-----LNISRI------------G 104

  Fly   225 DL-TSKKAW-IFVPCHGMTNC----------------SNNRSIIAEDKDQLDFVNVRMEQEGWYT 271
            |: ...:.| |.:.|.|..|.                :||.::|.:.|.    :.:|.||:..:.
  Fly   105 DVPVEPQTWGIALKCSGTRNAEVTVTINVEVILDRATNNNTNLIFKRKK----ICLREEQDSAHE 165

  Fly   272 CVESNSL--------GQSNSTAYL-----RVVRSLH---------VLEAGVASGS---------- 304
            ..:.:.|        |......|:     .||.:.|         |.|:.|..|:
  Fly   166 EYDDDDLDLLQTARKGHGGDIHYVDRNDEHVVANGHQAPEKQRPVVTESPVGRGNSGGSKRDFDP 230

  Fly   305 ------LHSTSFVYIFVFGGLIFIFM--TTLFVFYAIR--KMKHEK----VLK----QRIETVHQ 351
                  :...|.:...:.||::.:.:  |.:.:.|..:  ..:|..    ::|    ||:.|:..
  Fly   231 MLRENLVPPASGLVTLIVGGILALVLVSTLILIAYCAKGPSKRHPSNGVHLIKTSSFQRLPTISS 295

  Fly   352 WTKKVIIFKPEGGGDSSGSMDTMIMPVVRIQKQRTTVLQNGNEPAPFNEYEF-PLDSNWEL---- 411
            .....|...|           :.|.|..      .|:.:      ||.|||. |.:.|..|
  Fly   296 TAHNSIYVCP-----------STITPTY------ATLTR------PFREYEHEPEEFNRRLQELT 337

  Fly   412 -PRSHLVLGATLGEGAFGRVVMAEVNNA-IVAVKMVKEGHTDDDIASLVREMEVMKIIGRHINII 474
             .:..:.|...:.||.|||:.....|:. .|.||.|.: |......:|:.:..:|.....|.|::
  Fly   338 VQKCRVRLSCLVQEGNFGRIYRGTYNDCQEVLVKTVAQ-HASQLQVNLLLQESMMLYEASHPNVL 401

  Fly   475 NLLGCCSQNGPLYV--IVEYAPHG---NLKDFLYKNRPFGRDQDRDSSQPPPSPPAHVITEKDLI 534
            ::||...::   |.  .|.||..|   |||.||         ||       || .|..:|....:
  Fly   402 SVLGISIED---YATPFVLYAATGSVRNLKSFL---------QD-------PS-YARSVTTIQTV 446

  Fly   535 KFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKW 599
            ....|:|..|::|.:...||:|:||||.::.|...:|:.|..|:||:...||.........||||
  Fly   447 LMGSQLAMAMEHLHNHGVIHKDIAARNCVIDDQLRVKLTDSALSRDLFPGDYNSLGDGEYRPIKW 511

  Fly   600 MAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIY 664
            ::.|:||:..|:..|||||:|:|:||:.|.|:.||..| ...|:..||..|.|:.:|..|...::
  Fly   512 LSLEALQKSHYNEGSDVWSFGVLMWEMCTLGKLPYAEI-DPYEMEHYLKDGYRLAQPFNCPDELF 575

  Fly   665 ILMRQCWHFNADDRPPFTEI 684
            .:|..||.....:||.|:::
  Fly   576 TIMAYCWASMPAERPSFSQL 595

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	112..191	CDD:299845	19/95 (20%)
		IG_like	113..191	CDD:214653	19/95 (20%)
		IG_like	205..289	CDD:214653	18/114 (16%)
		PKc_like	404..692	CDD:304357	91/292 (31%)
		STYKc	416..688	CDD:214568	88/275 (32%)
drl	NP_001260566.1	WIF	21..157	CDD:128745	29/173 (17%)
		PTK_Ryk	336..606	CDD:270639	88/282 (31%)
		Pkinase_Tyr	343..599	CDD:285015	88/275 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455249
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940