Protein Alignment htl and Ret

DIOPT Version :10

• Sequence 1: NP_524394.2
• Gene: htl / 42160
• FlyBaseID: FBgn0010389
• Length: 729
• Species: Drosophila melanogaster
• Sequence 2: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Alignment Length: 433
• Identity: 150/433 - (34%)
• Similarity: 230/433 - (53%)
• Gaps: 59/433 - (13%)

  Fly   309 SFVYIFVFGGLIFIFMTTLFVFYAIRKMKHEKVLKQRIETVHQWTKKVIIFKPEGGGDSSGSMDT 373
            |.::..:...|:|:.: .|.:..|.|||...::.||.:.|.   :|:.:   ||.||.     |.
  Fly   694 SCMFFVITCPLLFVLL-LLCLLIAQRKMLQRRLGKQSMTTS---SKQAL---PESGGG-----DF 746

  Fly   374 MIMPVVRIQKQRTTVLQNGNEPAPFNEYEFPL-DSNWELPRSHLVLGATLGEGAFGRVVMAEVNN 437
            .:||           ||:|        :.|.. |:.||.||..|.|...||||.||:|:......
  Fly   747 ALMP-----------LQSG--------FRFESGDAKWEFPREKLQLDTVLGEGEFGQVLKGFATE 792

  Fly   438 -------AIVAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPH 495
                   ..|||||:|:|....:..:|:.|.::::.:. |.|:|.|||.|:.:....:|:|||.:
  Fly   793 IAGLPGITTVAVKMLKKGSNSVEYMALLSEFQLLQEVS-HPNVIKLLGACTSSEAPLLIIEYARY 856

  Fly   496 GNLKDFLYKNRPF---GRDQDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDL 557
            |:|:.:|..:|..   |.| ..|..:|        :..|.::.||.||.:||.||:..:.:||||
  Fly   857 GSLRSYLRLSRKIECAGVD-FADGVEP--------VNVKMVLTFAWQICKGMAYLSELKLVHRDL 912

  Fly   558 AARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGIL 622
            ||||||::|..:.||:||||.||:...|.|.|.:..|:|:||||||||.:..|.|||||||:|:|
  Fly   913 AARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRVPVKWMAPESLADHVYTSKSDVWSFGVL 977

  Fly   623 LWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEY 687
            .||::|.|..|||.| :.:.|::.|.:|.||::|..||..:|.::|.||....:.||.|..:...
  Fly   978 CWELITLGASPYPGI-APQNLWSLLKTGYRMDRPENCSEAVYSIVRTCWADEPNGRPSFKFLASE 1041

  Fly   688 MDKLLQTKEDYLDVDIANLDTPPSTSDE------EEDETDNLQ 724
            .:|||.....|:|::...:..|....|:      |..|.::||
  Fly  1042 FEKLLGNNAKYIDLETNAVSNPLYCGDDSALITTELGEPESLQ 1084

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	101..191	CDD:472250
		Ig strand B	121..125	CDD:409353
		Ig strand C	134..138	CDD:409353
		Ig strand E	157..161	CDD:409353
		Ig strand F	171..176	CDD:409353
		Ig strand G	184..187	CDD:409353
		Ig	200..289	CDD:472250
		Ig strand B	216..220	CDD:409353
		Ig strand C	229..233	CDD:409353
		Ig strand E	255..259	CDD:409353
		Ig strand F	269..274	CDD:409353
		Ig strand G	282..285	CDD:409353
		Protein Kinases, catalytic domain	404..692	CDD:473864	117/298 (39%)
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	114/289 (39%)