DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment htl and Eph

DIOPT Version :9

Sequence 1:	NP_524394.2	Gene:	htl / 42160	FlyBaseID:	FBgn0010389	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_524625.3	Gene:	Eph / 43803	FlyBaseID:	FBgn0025936	Length:	1096	Species:	Drosophila melanogaster

Alignment Length:	764	Identity:	189/764 - (24%)
Similarity:	303/764 - (39%)	Gaps:	194/764 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 KTPAITN------NANQSSTSS----------ADLDDGAADDDDNKADLPVNV--------SSKP 101
            |:|.:|.      |:|.|.|.|          ...:||......:....|.|:        |:..
  Fly   341 KSPEVTKCTPCPPNSNASKTGSPFCKCASGFYRHPNDGRHMPCYSPPAAPTNLTLLFVDQTSAII 405

  Fly   102 YWRNPKKMSFLQTRPSGSL------LTLNCHALGNPEPNITWYRNGTVDWTRGYGSLKRNRWTLT 160
            .|..|.|.....:..:..:      ..:.|:..   .||:.:  |.:.|        ..|...:|
  Fly   406 SWSAPAKNESFSSETNSKIYHSDIVYKIKCNIC---SPNVVY--NPSTD--------TFNETKIT 457

  Fly   161 MEDLVPGDCGNYTCKV--CNSLGCI----RHDTQ---VIVSDRVNHKPILMTGPLNLTLVVNSTG 216
            :.:|.|  ...||.::  .||:..|    ||..:   |.|||.|.....|:..||:|..|  .||
  Fly   458 LTNLEP--VTTYTVQIHAINSVSHINEFKRHSNESSLVAVSDIVFSNTSLLNIPLDLNEV--KTG 518

  Fly   217 SMHCKYLSDLTSKKAWIFVPCHGMTNCSNNRSIIAEDKD-------------QLDFVNVRMEQEG 268
            .....:.::...           ::...|.|.:...:||             .|:|..||
  Fly   519 QAEIVFTTESVL-----------LSTVFNLRILAITNKDADLEWDKPVQSDFPLEFYEVR----- 567

  Fly   269 WY-----------------------------------TCVESNSLGQSNSTAYLRVVRSLHVLEA 298
            |:                                   .|..:|..|..::..|.:.::|:
  Fly   568 WFPKVELDAINKSALNTKETKAHIVGLLENTEYGFQVRCKTNNGFGSYSNMIYAQTLQSV----- 627

  Fly   299 GVASGSLHSTSFVYIFVFG----GLIFIFMTTLFVFYAIRKMKHEKVLKQRIETVHQWTKKVIIF 359
                ||::..|....|:.|    |::|:.:..:...|.:|. ||:..|.:: .|.|      :..
  Fly   628 ----GSVYDDSVQIRFIAGAIVTGVLFLVIFIIATVYFMRS-KHQDDLDKK-STNH------LPL 680

  Fly   360 KPEGGGDSSGSMDTMIMPVVRIQKQRTTVLQNGN-----EPAPFNEYEFPLDSNWELPR----SH 415
            ..:...:...||||  .|:|:......|....||     :|   :.||.|..:..|..|    ::
  Fly   681 PLDYASNEVNSMDT--TPIVKKLHLNVTTPLFGNSRSYVDP---HTYEDPNQAIREFAREIDANY 740

  Fly   416 LVLGATLGEGAFGRVVMAE-------VNNAIVAVKMVKEGHTDDDIASLVREMEVMKIIGR--HI 471
            :.:.|.:|.|.||.|....       |.:..||:|.:|.|.::......:.|..:|   |:  |.
  Fly   741 ITIEAIIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGSSEKARCDFLTEASIM---GQFDHP 802

  Fly   472 NIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPSPPAHVITEKDLIKF 536
            |:|.|.|..:::.|:.:|.||..:|:|..||..|.  |:.|                 ...||..
  Fly   803 NVIYLQGVVTRSNPVMIITEYMENGSLDTFLRVND--GKFQ-----------------TLQLIVM 848

  Fly   537 AHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMA 601
            ...||.||.||:....:|||||||||||:...:.|||||||:|:|::.........|::|::|.|
  Fly   849 LRGIASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADFGLSREIENASDAYTTRGGKIPVRWTA 913

  Fly   602 PESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYIL 666
            ||::..:.:.|.|||||||::|||:|:||::||.. .|.:::...:..|.|:..|..|...:|.|
  Fly   914 PEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWN-WSNQDVIKSIEKGYRLPAPMDCPEALYQL 977

  Fly   667 MRQCWHFNADDRPPFTEIVEYMDKLLQTKEDYLDVDIANLDTPPSTSDE 715
            |..||......||.|..||..:|.|.:..:..       |.|.||...:
  Fly   978 MLDCWQKQRTHRPTFASIVSTLDNLARQPQSL-------LTTRPSPESD 1019

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	112..191	CDD:299845	17/93 (18%)
		IG_like	113..191	CDD:214653	17/92 (18%)
		IG_like	205..289	CDD:214653	19/131 (15%)
		PKc_like	404..692	CDD:304357	100/300 (33%)
		STYKc	416..688	CDD:214568	96/280 (34%)
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439
		FN3	387..476	CDD:238020	17/103 (17%)
		FN3	536..623	CDD:238020	13/91 (14%)
		EphA2_TM	644..736	CDD:291255	24/104 (23%)
		PTKc_EphR	736..1002	CDD:270629	97/288 (34%)
		Pkinase_Tyr	741..999	CDD:285015	96/280 (34%)
		SAM_1	1033..1092	CDD:278937
		SAM	1039..1092	CDD:197735
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455235
Domainoid	1	1.000	165	1.000	Domainoid score	I1208
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.940