DRSC/TRiP Functional Genomics Resources

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Protein Alignment htl and MAP3K11

DIOPT Version :10

Sequence 1:NP_524394.2 Gene:htl / 42160 FlyBaseID:FBgn0010389 Length:729 Species:Drosophila melanogaster
Sequence 2:NP_002410.1 Gene:MAP3K11 / 4296 HGNCID:6850 Length:847 Species:Homo sapiens


Alignment Length:395 Identity:117/395 - (29%)
Similarity:163/395 - (41%) Gaps:90/395 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   325 TTLFVF-------YAIRKMKHEKVLKQRIETVHQWTKKVIIFKPEG--GGDSSGSMDTMIMPVVR 380
            |.||.:       .|:||....:||          ::...|...||  .|...|.:.  |.|   
Human    47 TALFDYEPSGQDELALRKGDRVEVL----------SRDAAISGDEGWWAGQVGGQVG--IFP--- 96

  Fly   381 IQKQRTTVLQNGNEPAPFNEYEFPLDSNWELPRSHLVLGATLGEGAFGRVVMAEVNNAIVAVKMV 445
                 :..:..|..|.|.....|          ..|.|...:|.|.||:|........:||||..
Human    97 -----SNYVSRGGGPPPCEVASF----------QELRLEEVIGIGGFGKVYRGSWRGELVAVKAA 146

  Fly   446 KEGHTDDDI---ASLVREMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRP 507
            :: ..|:||   |..||:...:..:..|.|||.|...|.:...|.:::|||..|.|...|...| 
Human   147 RQ-DPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRR- 209

  Fly   508 FGRDQDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMDYLASRRC------IHRDLAARNVLV-- 564
                           .|.||     |:.:|.||||||.||   .|      |||||.:.|:|:  
Human   210 ---------------VPPHV-----LVNWAVQIARGMHYL---HCEALVPVIHRDLKSNNILLLQ 251

  Fly   565 ---SDDY---VLKIADFGLARDIQSTDYYRKNT--NGRLPIKWMAPESLQEKFYDSKSDVWSYGI 621
               |||.   .|||.||||||:      :.|.|  :......|||||.::...:...|||||:|:
Human   252 PIESDDMEHKTLKITDFGLARE------WHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGV 310

  Fly   622 LLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVE 686
            ||||::| |:.||..|......|...::...:..|:.|......||..||..:...||.|..|::
Human   311 LLWELLT-GEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQ 374

  Fly   687 YMDKL 691
            .::.|
Human   375 QLEAL 379

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
htlNP_524394.2 Ig 101..191 CDD:472250
Ig strand B 121..125 CDD:409353
Ig strand C 134..138 CDD:409353
Ig strand E 157..161 CDD:409353
Ig strand F 171..176 CDD:409353
Ig strand G 184..187 CDD:409353
Ig 200..289 CDD:472250
Ig strand B 216..220 CDD:409353
Ig strand C 229..233 CDD:409353
Ig strand E 255..259 CDD:409353
Ig strand F 269..274 CDD:409353
Ig strand G 282..285 CDD:409353
Protein Kinases, catalytic domain 404..692 CDD:473864 98/307 (32%)
MAP3K11NP_002410.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 11..38
SH3_MLK1-3 45..102 CDD:212992 15/74 (20%)
STKc_MLK3 113..379 CDD:271049 98/307 (32%)
Leucine-zipper 1 403..424
Leucine-zipper 2 438..459
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 537..643
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 655..847
Blue background indicates that the domain is not in the aligned region.

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