DRSC/TRiP Functional Genomics Resources

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Protein Alignment htl and MAP3K9

DIOPT Version :10

Sequence 1:NP_524394.2 Gene:htl / 42160 FlyBaseID:FBgn0010389 Length:729 Species:Drosophila melanogaster
Sequence 2:XP_011535090.1 Gene:MAP3K9 / 4293 HGNCID:6861 Length:1166 Species:Homo sapiens


Alignment Length:390 Identity:113/390 - (28%)
Similarity:169/390 - (43%) Gaps:83/390 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   352 WTKKVIIFKPEGGGDSSGSMDTMIMPVVRIQKQRTTVLQNGNE---PAPFNEYEFPLDSNWELPR 413
            ||   .:|:.|..|:.  .:...:..||.:..:.:.|  :|:|   ....|:......||:..||
Human    57 WT---AVFEYEAAGED--ELTLRLGDVVEVLSKDSQV--SGDEGWWTGQLNQRVGIFPSNYVTPR 114

  Fly   414 S---------------------------HLVLGATLGEGAFGRVVMAEVNNAIVAVKMVKEGHTD 451
            |                           .|.|...:|.|.||:|..|......||||..:. ..|
Human   115 SAFSSRCQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARH-DPD 178

  Fly   452 DDIASLV----REMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQ 512
            :||:..:    :|.::..:: :|.|||.|.|.|.:...|.:::|:|..|.|...|...|      
Human   179 EDISQTIENVRQEAKLFAML-KHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKR------ 236

  Fly   513 DRDSSQPPPSPPAHVITEKDLIKFAHQIARGMDYL---ASRRCIHRDLAARNVLV--------SD 566
                     .||      ..|:.:|.||||||:||   |....|||||.:.|:|:        ..
Human   237 ---------IPP------DILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLS 286

  Fly   567 DYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQ 631
            :.:|||.||||||:...|.  :.:..|  ...|||||.::...:...|||||||:||||::| |:
Human   287 NKILKITDFGLAREWHRTT--KMSAAG--TYAWMAPEVIRASMFSKGSDVWSYGVLLWELLT-GE 346

  Fly   632 QPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKLLQTKE 696
            .|:..|......|...|:...:..|:.|......||..||:.:...||.||.|   :|:|...:|
Human   347 VPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNI---LDQLTTIEE 408

  Fly   697  696
            Human   409  408

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
htlNP_524394.2 Ig 101..191 CDD:472250
Ig strand B 121..125 CDD:409353
Ig strand C 134..138 CDD:409353
Ig strand E 157..161 CDD:409353
Ig strand F 171..176 CDD:409353
Ig strand G 184..187 CDD:409353
Ig 200..289 CDD:472250
Ig strand B 216..220 CDD:409353
Ig strand C 229..233 CDD:409353
Ig strand E 255..259 CDD:409353
Ig strand F 269..274 CDD:409353
Ig strand G 282..285 CDD:409353
Protein Kinases, catalytic domain 404..692 CDD:473864 100/329 (30%)
MAP3K9XP_011535090.1 SH3_MLK1-3 56..113 CDD:212992 13/62 (21%)
STKc_MLK1 137..406 CDD:271047 96/299 (32%)
Blue background indicates that the domain is not in the aligned region.

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