DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment htl and InR

DIOPT Version :9

Sequence 1:	NP_524394.2	Gene:	htl / 42160	FlyBaseID:	FBgn0010389	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_001138093.1	Gene:	InR / 42549	FlyBaseID:	FBgn0283499	Length:	2144	Species:	Drosophila melanogaster

Alignment Length:	377	Identity:	132/377 - (35%)
Similarity:	199/377 - (52%)	Gaps:	51/377 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   389 LQNGNEPAPFNEYEFPLDSNWELPRSHLVLGATLGEGAFGRVVMAEVN----NAI---VAVKMVK 446
            |....|..||......:..:||:.|.:::..|.||:|:||.|....:.    |.:   .|:|.|.
  Fly  1344 LHMNTEVNPFYASMQYIPDDWEVLRENIIQLAPLGQGSFGMVYEGILKSFPPNGVDRECAIKTVN 1408

  Fly   447 EGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRD 511
            |..||.:..:.:.|..|||....: :::.|||.||:..|..|::|....|:||.:|..:||..||
  Fly  1409 ENATDRERTNFLSEASVMKEFDTY-HVVRLLGVCSRGQPALVVMELMKKGDLKSYLRAHRPEERD 1472

  Fly   512 QD----------RDSSQPPPSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSD 566
            :.          ..:.|||        |...:.:.|.:||.||.|||:::.:||||||||.:|:|
  Fly  1473 EAMMTYLNRIGVTGNVQPP--------TYGRIYQMAIEIADGMAYLAAKKFVHRDLAARNCMVAD 1529

  Fly   567 DYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQ 631
            |..:||.|||:.|||..||||||.|.|.||::||.||||::..|.|.|||:|:|::|||:.|...
  Fly  1530 DLTVKIGDFGMTRDIYETDYYRKGTKGLLPVRWMPPESLRDGVYSSASDVFSFGVVLWEMATLAA 1594

  Fly   632 QPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKL----- 691
            |||.. :|.|::..|::.|..||:|..|...::.||::|||..:..||.|.:|:.|::..
  Fly  1595 QPYQG-LSNEQVLRYVIDGGVMERPENCPDFLHKLMQRCWHHRSSARPSFLDIIAYLEPQCPNSQ 1658

  Fly   692 ------------LQTKE------DYLDVDIA-NLDTPPSTSDEEEDETDNLQ 724
                        ||.:|      :.||...| .||......:::||.|..|:
  Fly  1659 FKEVSFYHSEAGLQHREKERKERNQLDAFAAVPLDQDLQDREQQEDATTPLR 1710

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	112..191	CDD:299845
		IG_like	113..191	CDD:214653
		IG_like	205..289	CDD:214653
		PKc_like	404..692	CDD:304357	116/321 (36%)
		STYKc	416..688	CDD:214568	112/288 (39%)
InR	NP_001138093.1	Recep_L_domain	356..465	CDD:279382
		Furin-like	512..645	CDD:279142
		FU	545..592	CDD:238021
		Recep_L_domain	663..781	CDD:279382
		FN3	1224..1302	CDD:238020
		PTKc_InsR_like	1364..1652	CDD:173625	116/297 (39%)
		Pkinase_Tyr	1371..1650	CDD:285015	112/288 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455237
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940