DRSC/TRiP Functional Genomics Resources

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Protein Alignment htl and MET

DIOPT Version :10

Sequence 1:NP_524394.2 Gene:htl / 42160 FlyBaseID:FBgn0010389 Length:729 Species:Drosophila melanogaster
Sequence 2:XP_011514525.1 Gene:MET / 4233 HGNCID:7029 Length:1409 Species:Homo sapiens


Alignment Length:556 Identity:159/556 - (28%)
Similarity:261/556 - (46%) Gaps:126/556 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   239 GMTNCSN----NRSIIAEDKDQLDFVNVRMEQEGWYTCVESNSLGQ------SNSTAYLRVVRSL 293
            |..:|.|    :.:::....:.|..:|..:..| |...:.|..||:      .|.|.        
Human   897 GNKSCENIHLHSEAVLCTVPNDLLKLNSELNIE-WKQAISSTVLGKVIVQPDQNFTG-------- 952

  Fly   294 HVLEAGVASGSLHSTSFVYIFVFGGLIFIFMTTLFVFYAIRKMKHEKVL-------KQRIETVH- 350
              |.|||.|   .||:.:.:..|             |..::|.|..|.|       ..|:.|.| 
Human   953 --LIAGVVS---ISTALLLLLGF-------------FLWLKKRKQIKDLGSELVRYDARVHTPHL 999

  Fly   351 --------------QWTKKVIIFK---PEG---GGDSSGSMDTMIMPVVRIQKQRTTVLQNGNEP 395
                          ..:.:.:.::   ||.   ....:||...:..|:..:....|:...:.:.|
Human  1000 DRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNGSCRQVQYPLTDMSPILTSGDSDISSP 1064

  Fly   396 APFNEYEFPLDS-NWELPRS--HLVLGAT---------LGEGAFGRVVMA--------EVNNAIV 440
            ...|.....|.: |.||.::  |:|:|.:         :|.|.||.|...        :::.|:.
Human  1065 LLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVK 1129

  Fly   441 AVKMVKEGHTD-DDIASLVREMEVMKIIGRHINIINLLGCC--SQNGPLYVIVEYAPHGNLKDFL 502
            ::..:    || .:::..:.|..:||... |.|:::|||.|  |:..|| |::.|..||:|::|:
Human  1130 SLNRI----TDIGEVSQFLTEGIIMKDFS-HPNVLSLLGICLRSEGSPL-VVLPYMKHGDLRNFI 1188

  Fly   503 YKNRPFGRDQDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDD 567
                       |:.:..|        |.||||.|..|:|:||.||||::.:||||||||.::.:.
Human  1189 -----------RNETHNP--------TVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEK 1234

  Fly   568 YVLKIADFGLARDIQSTDYY--RKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYG 630
            :.:|:||||||||:...:||  ...|..:||:||||.||||.:.:.:||||||:|:||||:||.|
Human  1235 FTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRG 1299

  Fly   631 QQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKLLQT- 694
            ..|||.: :..::..||:.|:|:.:|..|...:|.:|.:|||..|:.||.|:|:|..:..:..| 
Human  1300 APPYPDV-NTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTF 1363

  Fly   695 -KEDYLDVD--------IANLDTPPSTSDEEEDETD 721
             .|.|:.|:        :|...:..|:.|..:||.|
Human  1364 IGEHYVHVNATYVNVKCVAPYPSLLSSEDNADDEVD 1399

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
htlNP_524394.2 Ig 101..191 CDD:472250
Ig strand B 121..125 CDD:409353
Ig strand C 134..138 CDD:409353
Ig strand E 157..161 CDD:409353
Ig strand F 171..176 CDD:409353
Ig strand G 184..187 CDD:409353
Ig 200..289 CDD:472250 12/59 (20%)
Ig strand B 216..220 CDD:409353
Ig strand C 229..233 CDD:409353
Ig strand E 255..259 CDD:409353 1/3 (33%)
Ig strand F 269..274 CDD:409353 1/4 (25%)
Ig strand G 282..285 CDD:409353 1/2 (50%)
Protein Kinases, catalytic domain 404..692 CDD:473864 113/312 (36%)
METXP_011514525.1 Sema_MET 44..535 CDD:200539
PSI 538..580 CDD:214655
IPT_plexin_repeat1 582..675 CDD:238585
IPT_plexin_repeat2 676..759 CDD:238584
IPT_plexin_repeat3 761..856 CDD:238586
IPT 857..953 CDD:214657 12/66 (18%)
PTKc_Met_Ron 1101..1362 CDD:270649 106/286 (37%)
Blue background indicates that the domain is not in the aligned region.

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