DRSC/TRiP Functional Genomics Resources

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Protein Alignment htl and MATK

DIOPT Version :10

Sequence 1:NP_524394.2 Gene:htl / 42160 FlyBaseID:FBgn0010389 Length:729 Species:Drosophila melanogaster
Sequence 2:NP_002369.2 Gene:MATK / 4145 HGNCID:6906 Length:508 Species:Homo sapiens


Alignment Length:518 Identity:153/518 - (29%)
Similarity:233/518 - (44%) Gaps:113/518 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   240 MTNCSNNR---SIIAEDKDQLDFVNVRMEQEGWYTCVESNSLGQSN--STAYLR----------- 288
            :|.|.:.|   ..:|..|..:..:....|.:.||. |:.::.||..  :...||           
Human    55 ITKCEHTRPKPGELAFRKGDVVTILEACENKSWYR-VKHHTSGQEGLLAAGALREREALSADPKL 118

  Fly   289 --------------VVRSLHVLEAG---VASGSLHSTSFVYIFVFGGLIFIFMTTLFVFYAIRKM 336
                          .|:.|...|.|   |...:.|...:|....||                |.:
Human   119 SLMPWFHGKISGQEAVQQLQPPEDGLFLVRESARHPGDYVLCVSFG----------------RDV 167

  Fly   337 KHEKVLKQRIETVHQWTKKVIIF-----KPEGGGDSSGSMDTMIMPVVRIQKQRTTVLQNGNEPA 396
            .|.:||.:   ..|....:.:.|     ..|......|::.|.::...|         ::|.:.|
Human   168 IHYRVLHR---DGHLTIDEAVFFCNLMDMVEHYSKDKGAICTKLVRPKR---------KHGTKSA 220

  Fly   397 PFNEYEFPLDSNWELPRSHLVLGATLGEGAFGRVVMAEVNNAIVAVKMVKEGHTDDDIASLVREM 461
               |.|. ..:.|.|...||.|||.:|||.||.|:..|.....||||.:|   .|....:.:.|.
Human   221 ---EEEL-ARAGWLLNLQHLTLGAQIGEGEFGAVLQGEYLGQKVAVKNIK---CDVTAQAFLDET 278

  Fly   462 EVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPSPPAH 526
            .||..: :|.|::.|||.....| ||:::|:...|||.:||   |..||               .
Human   279 AVMTKM-QHENLVRLLGVILHQG-LYIVMEHVSKGNLVNFL---RTRGR---------------A 323

  Fly   527 VITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKN- 590
            ::....|::|:..:|.||:||.|::.:||||||||:|||:|.|.|::|||||:      ..||. 
Human   324 LVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAARNILVSEDLVAKVSDFGLAK------AERKGL 382

  Fly   591 TNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEK 655
            .:.|||:||.|||:|:...:.|||||||:|:||||:.:||:.|||. ||.:|:...:..|.|||.
Human   383 DSSRLPVKWTAPEALKHGKFTSKSDVWSFGVLLWEVFSYGRAPYPK-MSLKEVSEAVEKGYRMEP 446

  Fly   656 PAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKLLQTKEDYLDVDIANLDTPPSTSDEEED 718
            |..|...:::||..||......||||.::.|.:.:           ::.:...|.|.|.::.|
Human   447 PEGCPGPVHVLMSSCWEAEPARRPPFRKLAEKLAR-----------ELRSAGAPASVSGQDAD 498

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
htlNP_524394.2 Ig 101..191 CDD:472250
Ig strand B 121..125 CDD:409353
Ig strand C 134..138 CDD:409353
Ig strand E 157..161 CDD:409353
Ig strand F 171..176 CDD:409353
Ig strand G 184..187 CDD:409353
Ig 200..289 CDD:472250 13/78 (17%)
Ig strand B 216..220 CDD:409353
Ig strand C 229..233 CDD:409353
Ig strand E 255..259 CDD:409353 0/3 (0%)
Ig strand F 269..274 CDD:409353 2/4 (50%)
Ig strand G 282..285 CDD:409353 0/4 (0%)
Protein Kinases, catalytic domain 404..692 CDD:473864 113/288 (39%)
MATKNP_002369.2 SH3_CHK 51..109 CDD:212745 13/54 (24%)
SH3 domain 55..106 11/51 (22%)
SH2_csk_like 119..216 CDD:198190 19/124 (15%)
SH2 domain 123..213 18/108 (17%)
PTKc_Chk 229..482 CDD:270666 113/293 (39%)
catalytic domain 236..479 110/272 (40%)
Blue background indicates that the domain is not in the aligned region.

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