Protein Alignment htl and pdgfra

DIOPT Version :10

• Sequence 1: NP_524394.2
• Gene: htl / 42160
• FlyBaseID: FBgn0010389
• Length: 729
• Species: Drosophila melanogaster
• Sequence 2: XP_073788314.1
• Gene: pdgfra / 386856
• ZFINID: ZDB-GENE-990415-208
• Length: 1471
• Species: Danio rerio
• Alignment Length: 775
• Identity: 216/775 - (27%)
• Similarity: 330/775 - (42%)
• Gaps: 189/775 - (24%)

  Fly   118 GSLLTLNCHALGNPEPNITWYRNGTVDWTRGYGSLKRNR------WTLTMEDLVPGDCGNYTCKV 176
            |..:|::|.|.|:......|...|.:. .||..::|.|:      :|||:.:..|.|.|.|.|.:
Zfish   615 GETITVDCVAKGSEMLEDHWKYPGKLA-NRGTKTVKENKLNLEIYYTLTVTNASPKDSGIYACSI 678

  Fly   177 CNSLGCIRHDTQ-----VIVSDR--VNHKPILMTGPLNLTLVVNSTGSMHCKYLSDLTSKKAWI- 233
            .:.:.   :::|     :.|.|.  |:..|::  ||:. |..::..........|....|..|:
Zfish   679 TDIMS---NESQTKELTITVYDHEFVHINPLI--GPVE-TARLDEVPEFKVDIESFPAPKVTWLK 737

  Fly   234 --FVPCHGMTNCSNNRSIIAED--KDQLDFVNVRMEQEGWYTC-VESNSLGQSNSTAYLR----- 288
              .|........|.|...|.|.  |..|:.:..:.|..|.||. .|..|:..|.| .||:
Zfish   738 DSAVLGDDTAEISTNLLKIGETSYKGVLNLIRAKAEDSGNYTVKAEIGSISTSYS-FYLQVKVPP 801

  Fly   289 VVRSLHVLEAGVASGSLHSTSFVYIFVFGGLIFIFMTTLFVFYAIRKMKH--------------- 338
            |:..|..:..|.|:|.      ..:...||..|..:.    :|..:.:||
Zfish   802 VIVDLIDVHHGSAAGQ------EVVCTAGGSPFPEVD----WYICKNLKHCANDSSQWMPLPINS 856

  Fly   339 -EKVLKQRIETVHQWTKKVIIFKPEG--------GGD-----------SSGS------------- 370
             :..::.::...:.....:|....||        ..|           |||.
Zfish   857 TDITVELQMNVDNHIESHIIFHHLEGTVAVRCLARNDMGVVSREVKLMSSGPHSELTVAAAVLVL 921

  Fly   371 -----MDTMIMPVVRIQKQR--------TTVLQNGNEPAPFNEYEFPLDSNWELPRSHLVLGATL 422
                 :..:::.::..||.|        .:|..:|:|....:..:.|.||.||.||..||||..|
Zfish   922 LVIVIISLIVLVIIWKQKPRYEIRWRVIESVSPDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRVL 986

  Fly   423 GEGAFGRVVMAEVNNAI-------VAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCC 480
            |.||||:||........       |||||:|......:..:|:.|:::|..:|.|:||:||||.|
Zfish   987 GSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGAC 1051

  Fly   481 SQNGPLYVIVEYAPHGNLKDFLYKNRP----------------FGRD------------------ 511
            :::||:|:|.||..:|:|.::|:|||.                ||.:
Zfish  1052 TKSGPIYIITEYCFYGDLVNYLHKNRDGFLSRHTEKGKKDLDIFGINPADESSRSYVILSFEGKG 1116

  Fly   512 -----QDRDSSQPPP-------------------SPPAH-----------------VITEKDLIK 535
                 :..|:.|..|                   .||:|                 .:|..||:.
Zfish  1117 DYMDMKQADTMQYVPMLEMNEASKYSPIQRSDYDHPPSHRQFNDEAESLLSDDSAEGLTTMDLLS 1181

  Fly   536 FAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWM 600
            |.:|:||||::|||:.|:||||||||||:|...::||.||||||||...:.|....:..||:|||
Zfish  1182 FTYQVARGMEFLASKNCVHRDLAARNVLLSQGKIVKICDFGLARDIMHDNNYVSKGSTFLPVKWM 1246

  Fly   601 APESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYI 665
            ||||:.:..|.:.|||||||||||||.:.|..|||.::.....|..:.||.||.||...|.::|.
Zfish  1247 APESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMVVDSSFYNKIKSGYRMTKPEHASSDVYE 1311

  Fly   666 LMRQCWHFNADDRPPFTEIVEYMDKLLQT--KEDY--LDVDIANLDTPPSTSDEEEDETD 721
            ||.:||:...:.||.|..:.:.:..||.:  |..|  ::.|....|.|..|..:..|..|
Zfish  1312 LMMKCWNSEPEKRPSFHSLSDTVASLLPSGFKRCYERVNHDFLKSDHPAVTRVQCIDNDD 1371

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	101..191	CDD:472250	20/83 (24%)
		Ig strand B	121..125	CDD:409353	1/3 (33%)
		Ig strand C	134..138	CDD:409353	0/3 (0%)
		Ig strand E	157..161	CDD:409353	2/3 (67%)
		Ig strand F	171..176	CDD:409353	2/4 (50%)
		Ig strand G	184..187	CDD:409353	0/2 (0%)
		Ig	200..289	CDD:472250	23/99 (23%)
		Ig strand B	216..220	CDD:409353	0/3 (0%)
		Ig strand C	229..233	CDD:409353	1/3 (33%)
		Ig strand E	255..259	CDD:409353	1/3 (33%)
		Ig strand F	269..274	CDD:409353	2/5 (40%)
		Ig strand G	282..285	CDD:409353	1/2 (50%)
		Protein Kinases, catalytic domain	404..692	CDD:473864	135/369 (37%)
pdgfra	XP_073788314.1	None