Protein Alignment htl and Tie

DIOPT Version :10

• Sequence 1: NP_524394.2
• Gene: htl / 42160
• FlyBaseID: FBgn0010389
• Length: 729
• Species: Drosophila melanogaster
• Sequence 2: NP_523928.1
• Gene: Tie / 38559
• FlyBaseID: FBgn0014073
• Length: 1233
• Species: Drosophila melanogaster
• Alignment Length: 770
• Identity: 180/770 - (23%)
• Similarity: 279/770 - (36%)
• Gaps: 235/770 - (30%)

  Fly    57 RSQNKTPAITNNANQSSTSSADLDDGAADDDDNKADLPVNVSSKPYWRNPKKMSFLQTRPSGSLL 121
            |:....|..|.|...::|||. ..........:...:|....:.......|::    .|..|..|
  Fly   549 RTTTNAPLSTTNTPTTTTSST-TPSTTTTSSTSTTVIPTTTKANSIIEKDKEL----IRALGPAL 608

  Fly   122 TLNCHALGNPEPNITWYRNGTVDWTRGYGSLKRNRWTLTMEDLVPGDCGNYTCKVCNSLGCIRHD 186
            |...:.  :...|:..:.|.|                        .|||            :...
  Fly   609 TREINI--DDANNLIVFCNNT------------------------SDCG------------VTPR 635

  Fly   187 TQVIVSDRVNHKPILMTGPLNLTLVVNSTGSMHCKYLSDLTSKKAWIFVP----------CHGMT 241
            ||...|...:..|.:    |..|::.:...::|.:..|..|:.......|          ..|:.
  Fly   636 TQTQPSHTTDSSPKI----LRTTVLTSIRSTVHPRPTSTSTTTSTTTTAPPAVTAPSNEVYIGIV 696

  Fly   242 NCSNNRS-------IIAEDKDQLDFVNVRMEQEGWYTCVESNSLGQSNSTAYLRVVRSLHVLEAG 299
            ..|::.|       :||.::|    :|:.|.:....|.|.
  Fly   697 ESSSSASPADISSTVIANERD----LNMEMRRMNLVTLVL------------------------- 732

  Fly   300 VASGSLHSTSFVYIFVFGGLIFIFMTTLFVFYAIRKMKHEKVL------KQRIETVHQWTKKVII 358
            ||.|.:...:          |.:::...||..  |:.|..:|.      :|.|..|.:...|..:
  Fly   733 VAVGVIPLAA----------IILYLVRNFVIR--RRAKQSEVFDVCITDQQPISPVKKVDSKYQV 785

  Fly   359 FKPEGGGD---------------SSGSMDTMIMPVVRIQKQRTTVLQNGNEPAPFNEYEFPLDSN 408
            ...|...|               .........||:.:..::.....:.||     |:.:..|.|.
  Fly   786 DDDEDEVDHQHHQHMQHHQNHQNHQNHQHHQAMPMSQASQRDANHNRYGN-----NDDKTSLASE 845

  Fly   409 W-ELPRSHLVLGATLGEGAFGRVVMAEVNN--------AIVAVKMVKEGHTDDDIASLVREMEVM 464
            : :..||::.|.:.||||.||:|..||.::        .|||||.::.....   .||..|..:|
  Fly   846 FHDFERSNIRLKSLLGEGNFGQVWKAEADDLSGHFGATRIVAVKTIRACSAQ---VSLKDEANIM 907

  Fly   465 KIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNR----------PFGRDQDRDSSQP 519
            :.:|.|.|::.|||.|.::.|..:|:|||..|.|...|...|          |.||      |..
  Fly   908 RKLGSHQNVVTLLGACVESEPHMLIMEYAMRGRLLSLLRAARSATNILPASVPGGR------SLA 966

  Fly   520 PPSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQ-- 582
            |.||       :.|..||..||.||:|:|.||.:||||||||||:..:.:.||.|||::.|:.
  Fly   967 PLSP-------RTLAGFALDIACGMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDLDAE 1024

  Fly   583 ----------STDYYRKN----------------------------------------------T 591
                      :.|..|.|                                              |
  Fly  1025 RMRKEQEKNAANDLMRHNAHKFKFDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDT 1089

  Fly   592 NGR---LPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRM 653
            .|:   |||:||||||||...:.:::|:|::||:||||.|.|..|| :.::..|:...:..|.|.
  Fly  1090 IGKRHALPIRWMAPESLQYHMFTTETDIWAFGIVLWEIATLGSTPY-SQLTGREVIRRVPQGLRP 1153

  Fly   654 EKPAKCSMNIYILMRQCWHFNADDRPPFT----EIVEYMDKLL---QTKEDYLDV 701
            :.|.:.....|.||.:|||.....||.|.    ||...:.|.:   ....||:||
  Fly  1154 DLPKESRHEFYNLMSRCWHKEPHMRPSFAQSRLEITRSLHKWVDDDSAASDYMDV 1208

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	101..191	CDD:472250	13/89 (15%)
		Ig strand B	121..125	CDD:409353	2/3 (67%)
		Ig strand C	134..138	CDD:409353	1/3 (33%)
		Ig strand E	157..161	CDD:409353	0/3 (0%)
		Ig strand F	171..176	CDD:409353	0/4 (0%)
		Ig strand G	184..187	CDD:409353	0/2 (0%)
		Ig	200..289	CDD:472250	16/105 (15%)
		Ig strand B	216..220	CDD:409353	0/3 (0%)
		Ig strand C	229..233	CDD:409353	0/3 (0%)
		Ig strand E	255..259	CDD:409353	1/3 (33%)
		Ig strand F	269..274	CDD:409353	1/4 (25%)
		Ig strand G	282..285	CDD:409353	0/2 (0%)
		Protein Kinases, catalytic domain	404..692	CDD:473864	117/371 (32%)
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	110/345 (32%)